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GAMBOGIC ACID Drug Record

  • Summary
  • Interactions
  • Claims
  • GAMBOGIC ACID chembl:CHEMBL555017

    Alternate Names:

    GAMBOGIC ACID
    R-GAMBOGIC ACID
    (-)-GAMBOGIC ACID

    Drug Info:

    (0 More Sources)

    Publications:

    Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod
    Davenport J et al., 2011, Gambogic acid, a natural product inhibitor of Hsp90., J Nat Prod
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
    Sun H et al., 2012, Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)., Eur J Med Chem
  • GAMBOGIC ACID   TXN2

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22663155


    Sources:
    DTC

  • GAMBOGIC ACID   TXN

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22663155


    Sources:
    DTC

  • GAMBOGIC ACID   NFKBIA

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22472167


    Sources:
    DTC

  • GAMBOGIC ACID   MDM2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GAMBOGIC ACID   HSP90AB1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21486005


    Sources:
    DTC

  • GAMBOGIC ACID   MAPK3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • GAMBOGIC ACID   NTRK1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • GAMBOGIC ACID   HSP90AA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21486005


    Sources:
    DTC

  • GAMBOGIC ACID   MAPK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • DTC: GAMBOGIC ACID

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL555017 ChEMBL Drug ID

    Drug Info:

    Publications:
    Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
    Sun H et al., 2012, Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)., Eur J Med Chem

  • ChemblDrugs: chembl:CHEMBL555017

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21