DGIdb - GELDANAMYCIN Drug Record

GELDANAMYCIN chembl:CHEMBL278315 Antineoplastic

Alternate Names:

GELDANAMYCIN
NSC-122750
chemidplus:30562-34-6
drugbank:02424
chembl:CHEMBL278315
pubchem.compound:5288382

Drug Info:

(1 More Sources)

Publications:

Zagzag et al., 2003, Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion., J. Cell. Physiol.
Zhao H et al., 2011, Identification and initial SAR of silybin: an Hsp90 inhibitor., Bioorg Med Chem Lett
Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol
Hadden MK et al., 2007, Derrubone, an inhibitor of the Hsp90 protein folding machinery., J Nat Prod
Li Z et al., 2014, Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors., Eur J Med Chem
Matts RL et al., 2011, A systematic protocol for the characterization of Hsp90 modulators., Bioorg Med Chem
Kusuma BR et al., 2011, Targeting the heat shock protein 90 dimer with dimeric inhibitors., J Med Chem
Gunaherath GM et al., 2013, Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors., Bioorg Med Chem
Shaaban KA et al., 2013, Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15., J Nat Prod
Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Schnaider et al., 1998, The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes., Life Sci.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Gavenonis J et al., 2014, Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix., Bioorg Med Chem
Chen CY et al., 2014, The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis., J Med Chem
Li Z et al., 2014, Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors., Eur J Med Chem
Davenport J et al., 2011, Gambogic acid, a natural product inhibitor of Hsp90., J Nat Prod
Edwards et al., 1995, Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways., Blood
Nganga et al., 2000, Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94)., Biochem. J.
Zhang et al., 2006, HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis., Mol. Cell. Biochem.
Yun et al., 2005, Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation., Exp. Cell Res.
Luparello et al., 2003, PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression., J. Cell. Sci.
Puyo S et al., 2008, Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro., Mol Diagn Ther
George et al., 2004, Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3., Cancer Res.
George et al., 2005, Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3., Blood

GELDANAMYCIN CDC37

Interaction Score: 4.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21486005

Sources:
DTC
GELDANAMYCIN VIM

Interaction Score: 3.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16328963

Sources:
NCI
GELDANAMYCIN CEL

Interaction Score: 2.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11104697

Sources:
NCI
GELDANAMYCIN HSP90AB1

Interaction Score: 1.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources:
DTC GuideToPharmacology
GELDANAMYCIN CD28

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9747895

Sources:
NCI
GELDANAMYCIN MYOD1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15922741

Sources:
NCI
GELDANAMYCIN FCGR3B

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7662976

Sources:
NCI
GELDANAMYCIN HSP90AA1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21273068 18408713 18020309 25277067 21129982 21861487 23859777 23947794 25756299 17016423 17139284

Sources:
DTC
GELDANAMYCIN FCGR3A

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7662976

Sources:
NCI
GELDANAMYCIN PLAU

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12724357

Sources:
NCI
GELDANAMYCIN FLT3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15150124 15514006

Sources:
NCI
GELDANAMYCIN HIF1A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12811834

Sources:
NCI
GELDANAMYCIN EGFR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18652519

Sources:
PharmGKB
GELDANAMYCIN ATAD5

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: GELDANAMYCIN

Version: 14-September-2017

Alternate Names:

C1112 NCI drug code

Drug Info:

Publications:

Zagzag et al., 2003, Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion., J. Cell. Physiol.

Edwards et al., 1995, Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways., Blood

Schnaider et al., 1998, The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes., Life Sci.

DTC: GELDANAMYCIN

Version: 02-September-2020

Alternate Names:

CHEMBL278315 ChEMBL Drug ID

Drug Info:

Publications:

Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod

Li Z et al., 2014, Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors., Eur J Med Chem

Matts RL et al., 2011, A systematic protocol for the characterization of Hsp90 modulators., Bioorg Med Chem

PharmGKB: geldanamycin
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Puyo S et al., 2008, Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro., Mol Diagn Ther
GuideToPharmacology: 354702300
- Version: 29-September-2020
Alternate Names:

GELDANAMYCIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL278315
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

GELDANAMYCIN Drug Record

GELDANAMYCIN chembl:CHEMBL278315 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21486005

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16328963

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11104697

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9747895

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15922741

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7662976

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21273068 18408713 18020309 25277067 21129982 21861487 23859777 23947794 25756299 17016423 17139284

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7662976

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12724357

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15150124 15514006

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12811834

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18652519

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: GELDANAMYCIN

Alternate Names: C1112 NCI drug code

Drug Info:

DTC: GELDANAMYCIN

Alternate Names: CHEMBL278315 ChEMBL Drug ID

Drug Info:

PharmGKB: geldanamycin

Alternate Names:

Drug Info:

Publications: Puyo S et al., 2008, Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro., Mol Diagn Ther

GuideToPharmacology: 354702300

Alternate Names: GELDANAMYCIN GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL278315

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21486005

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16328963

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11104697

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9747895

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15922741

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7662976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21273068 18408713 18020309 25277067 21129982 21861487 23859777 23947794 25756299 17016423 17139284

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7662976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12724357

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15150124 15514006

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12811834

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18652519

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C1112 NCI drug code

Alternate Names:

CHEMBL278315 ChEMBL Drug ID

Publications:

Puyo S et al., 2008, Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro., Mol Diagn Ther

Alternate Names:

GELDANAMYCIN GuideToPharmacology Ligand Name