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GENISTEIN Drug Record

  • Summary
  • Interactions
  • Claims
  • GENISTEIN chembl:CHEMBL44 Antineoplastic

    Alternate Names:

    NSC-36586
    GENISTEIN
    SIPI-807-1
    FW-635I-2
    NPI-031L

    Drug Info:

    (1 More Sources)

    Publications:

    Wang et al., 2004, Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes., Biol. Reprod.
    Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori
    Edmiston et al., 1997, In vivo induction of murine cytokine production by carcinoembryonic antigen., Cancer Res.
    Ronis et al., 2006, Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats., Exp. Biol. Med. (Maywood)
    Mylonas et al., Immunohistochemical expression of steroid receptors and glycodelin A in isolated proliferative human endometrial glandular cells after stimulation with tamoxifen and phytoestrogens (genistein and daidzein)., Anticancer Res.
    Beard et al., 2005, The effects of genistein concentrations on Hep-2 cellular function., Biomed Sci Instrum
    Vera et al., 1996, Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1., J. Biol. Chem.
    Fang et al., 2005, Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy., Clin. Cancer Res.
    Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
    Derand et al., 2002, The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site., J. Biol. Chem.
    Arora K et al., 2016, Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation., Am J Physiol Lung Cell Mol Physiol
    Pasqualini et al., 2000, Phosphorylation of the rat pancreatic bile-salt-dependent lipase by casein kinase II is essential for secretion., Biochem. J.
    Tsukamoto et al., 1999, Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins., Am. J. Physiol.
    Zhang et al., 2004, Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport., Pharm. Res.
    Takii et al., 1999, Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells., Eur. Cytokine Netw.
    Edmunds et al., The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells., Reprod. Nutr. Dev.
    Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Good et al., 2001, Neurotrophin-3 inhibits HCO absorption via a cAMP-dependent pathway in renal thick ascending limb., Am. J. Physiol., Cell Physiol.
    Qi et al., 2001, [Antifibrotic effects of genistein and quercetin in vitro]., Yao Xue Xue Bao
    Rao et al., 1995, Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells., J. Cell. Physiol.
    Milerová et al., 2006, Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters., Clin. Chem. Lab. Med.
    Tonner et al., 1997, Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C., Toxicology
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod
    Cohen et al., 2002, Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors., Surgery
    Davis et al., 2000, Inhibition of prostate specific antigen expression by genistein in prostate cancer cells., Int. J. Oncol.
    Leduc et al., 1995, Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells., Mol. Pharmacol.
    Ahmed et al., 2002, Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer., J. Cell. Biochem.
    Ma et al., 2007, [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83]., Hua Xi Kou Qiang Yi Xue Za Zhi
    Uchiyama et al., 2007, Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells., Int. J. Mol. Med.
    Li et al., 2003, [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]., Zhonghua Kou Qiang Yi Xue Za Zhi
    Li et al., 2003, Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation., Biol. Pharm. Bull.
    Oki et al., 2004, Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line., FEBS Lett.
    Khandaker et al., 1998, CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism., J. Immunol.
    Smith et al., 1993, Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin., Arch. Biochem. Biophys.
    Yu et al., 2005, Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway., Biochem. Biophys. Res. Commun.
    Choi et al., 1998, Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells., Int. J. Oncol.
    Luo et al., 1999, Dopamine stimulates redox-tyrosine kinase signaling and p38 MAPK in activation of astrocytic C6-D2L cells., Brain Res.
  • GENISTEIN   PAEP

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12820358


    Sources:
    NCI

  • GENISTEIN   EPHA8

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15850105


    Sources:
    NCI

  • GENISTEIN   PTGES3

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15229138


    Sources:
    NCI

  • GENISTEIN   CCNA2

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9664138


    Sources:
    NCI

  • GENISTEIN   TJP1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10330056


    Sources:
    NCI

  • GENISTEIN   CEL

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10600647


    Sources:
    NCI

  • GENISTEIN   GADD45A

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15527761


    Sources:
    NCI

  • GENISTEIN   CEACAM5

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9331108


    Sources:
    NCI

  • GENISTEIN   IL1R1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10400830


    Sources:
    NCI

  • GENISTEIN   CFTR

    Interaction Score: 0.31

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    12124395 27261451


    Sources:
    NCI PharmGKB

  • GENISTEIN   TAT

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9128187


    Sources:
    NCI

  • GENISTEIN   CXCR2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9712063


    Sources:
    NCI

  • GENISTEIN   SLC2A1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8621505


    Sources:
    NCI

  • GENISTEIN   BGLAP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17203194 14680578 12808286


    Sources:
    NCI

  • GENISTEIN   NTF3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11698238


    Sources:
    NCI

  • GENISTEIN   KLK3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10811979


    Sources:
    NCI

  • GENISTEIN   TG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16475902


    Sources:
    NCI

  • GENISTEIN   MGMT

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16203797


    Sources:
    NCI

  • GENISTEIN   NRG1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17539658


    Sources:
    NCI

  • GENISTEIN   GFAP

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10629745


    Sources:
    NCI

  • GENISTEIN   PLG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11835393


    Sources:
    NCI

  • GENISTEIN   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284


    Sources:
    TTD

  • GENISTEIN   PRL

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7706371


    Sources:
    NCI

  • GENISTEIN   CYP19A1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16285913


    Sources:
    NCI

  • GENISTEIN   BIRC5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17375591


    Sources:
    NCI

  • GENISTEIN   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12580099


    Sources:
    NCI

  • GENISTEIN   TOP2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17016423 17139284 7769390


    Sources:
    DTC

  • GENISTEIN   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8424658


    Sources:
    NCI

  • GENISTEIN   AGTR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7476882


    Sources:
    NCI

  • GENISTEIN   GBA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   RET

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12490842


    Sources:
    NCI

  • GENISTEIN   ABCG2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15290869


    Sources:
    NCI

  • GENISTEIN   ABL1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9349317


    Sources:
    NCI

  • GENISTEIN   AHR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16038533 10592235


    Sources:
    DTC

  • GENISTEIN   NR1H4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   THPO

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   SMAD3

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15963949


    Sources:
    NCI

  • GENISTEIN   SMN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   SMN1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   NPC1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   RAB9A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   ATAD5

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16380645


    Sources:
    DTC NCI

  • GENISTEIN   TP53

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   CYP2C19

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: GENISTEIN

    • Version: 14-September-2017

    Alternate Names:
    C1113 NCI drug code

    Drug Info:

    Publications:
    Wang et al., 2004, Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes., Biol. Reprod.
    Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori
    Edmiston et al., 1997, In vivo induction of murine cytokine production by carcinoembryonic antigen., Cancer Res.

  • DTC: GENISTEIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL44 ChEMBL Drug ID

    Drug Info:

    Publications:
    Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
    Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod

  • PharmGKB: genistein

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Arora K et al., 2016, Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation., Am J Physiol Lung Cell Mol Physiol

  • TTD: Genistein

    • Version: 2020.06.01

    Alternate Names:
    D0L4FS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL44

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21