DGIdb - GENISTEIN Drug Record

GENISTEIN chembl:CHEMBL44 Antineoplastic

Alternate Names:

NSC-36586
GENISTEIN
SIPI-807-1
FW-635I-2
NPI-031L

Drug Info:

(1 More Sources)

Publications:

Wang et al., 2004, Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes., Biol. Reprod.
Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori
Edmiston et al., 1997, In vivo induction of murine cytokine production by carcinoembryonic antigen., Cancer Res.
Ronis et al., 2006, Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats., Exp. Biol. Med. (Maywood)
Mylonas et al., Immunohistochemical expression of steroid receptors and glycodelin A in isolated proliferative human endometrial glandular cells after stimulation with tamoxifen and phytoestrogens (genistein and daidzein)., Anticancer Res.
Beard et al., 2005, The effects of genistein concentrations on Hep-2 cellular function., Biomed Sci Instrum
Vera et al., 1996, Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1., J. Biol. Chem.
Fang et al., 2005, Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy., Clin. Cancer Res.
Pan et al., 2007, Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling., J. Agric. Food Chem.
Derand et al., 2002, The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site., J. Biol. Chem.
Arora K et al., 2016, Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation., Am J Physiol Lung Cell Mol Physiol
Pasqualini et al., 2000, Phosphorylation of the rat pancreatic bile-salt-dependent lipase by casein kinase II is essential for secretion., Biochem. J.
Tsukamoto et al., 1999, Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins., Am. J. Physiol.
Zhang et al., 2004, Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport., Pharm. Res.
Takii et al., 1999, Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells., Eur. Cytokine Netw.
Edmunds et al., The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells., Reprod. Nutr. Dev.
Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Good et al., 2001, Neurotrophin-3 inhibits HCO absorption via a cAMP-dependent pathway in renal thick ascending limb., Am. J. Physiol., Cell Physiol.
Qi et al., 2001, [Antifibrotic effects of genistein and quercetin in vitro]., Yao Xue Xue Bao
Rao et al., 1995, Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells., J. Cell. Physiol.
Milerová et al., 2006, Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters., Clin. Chem. Lab. Med.
Tonner et al., 1997, Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C., Toxicology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod
Cohen et al., 2002, Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors., Surgery
Davis et al., 2000, Inhibition of prostate specific antigen expression by genistein in prostate cancer cells., Int. J. Oncol.
Leduc et al., 1995, Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells., Mol. Pharmacol.
Ahmed et al., 2002, Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer., J. Cell. Biochem.
Ma et al., 2007, [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83]., Hua Xi Kou Qiang Yi Xue Za Zhi
Uchiyama et al., 2007, Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells., Int. J. Mol. Med.
Li et al., 2003, [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]., Zhonghua Kou Qiang Yi Xue Za Zhi
Li et al., 2003, Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation., Biol. Pharm. Bull.
Oki et al., 2004, Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line., FEBS Lett.
Khandaker et al., 1998, CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism., J. Immunol.
Smith et al., 1993, Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin., Arch. Biochem. Biophys.
Yu et al., 2005, Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway., Biochem. Biophys. Res. Commun.
Choi et al., 1998, Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells., Int. J. Oncol.
Luo et al., 1999, Dopamine stimulates redox-tyrosine kinase signaling and p38 MAPK in activation of astrocytic C6-D2L cells., Brain Res.

GENISTEIN PAEP

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12820358

Sources:
NCI
GENISTEIN EPHA8

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15850105

Sources:
NCI
GENISTEIN PTGES3

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15229138

Sources:
NCI
GENISTEIN CCNA2

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9664138

Sources:
NCI
GENISTEIN TJP1

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10330056

Sources:
NCI
GENISTEIN CEL

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10600647

Sources:
NCI
GENISTEIN GADD45A

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15527761

Sources:
NCI
GENISTEIN CEACAM5

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9331108

Sources:
NCI
GENISTEIN IL1R1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10400830

Sources:
NCI
GENISTEIN CFTR

Interaction Score: 0.31

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
12124395 27261451

Sources:
NCI PharmGKB
GENISTEIN TAT

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9128187

Sources:
NCI
GENISTEIN CXCR2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9712063

Sources:
NCI
GENISTEIN SLC2A1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621505

Sources:
NCI
GENISTEIN BGLAP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17203194 14680578 12808286

Sources:
NCI
GENISTEIN NTF3

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11698238

Sources:
NCI
GENISTEIN KLK3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10811979

Sources:
NCI
GENISTEIN TG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16475902

Sources:
NCI
GENISTEIN MGMT

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16203797

Sources:
NCI
GENISTEIN NRG1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17539658

Sources:
NCI
GENISTEIN GFAP

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10629745

Sources:
NCI
GENISTEIN PLG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11835393

Sources:
NCI
GENISTEIN ESR2

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10592235 17016423 17139284

Sources:
TTD
GENISTEIN PRL

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7706371

Sources:
NCI
GENISTEIN CYP19A1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16285913

Sources:
NCI
GENISTEIN BIRC5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17375591

Sources:
NCI
GENISTEIN TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12580099

Sources:
NCI
GENISTEIN TOP2A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284 7769390

Sources:
DTC
GENISTEIN SLC2A4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8424658

Sources:
NCI
GENISTEIN AGTR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7476882

Sources:
NCI
GENISTEIN GBA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN RET

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12490842

Sources:
NCI
GENISTEIN ABCG2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15290869

Sources:
NCI
GENISTEIN ABL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9349317

Sources:
NCI
GENISTEIN AHR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN ESR1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16038533 10592235

Sources:
DTC
GENISTEIN NR1H4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN RXRA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN THPO

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN SMAD3

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15963949

Sources:
NCI
GENISTEIN SMN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN SMN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN NPC1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN RAB9A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16380645

Sources:
DTC NCI
GENISTEIN TP53

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: GENISTEIN

Version: 14-September-2017

Alternate Names:

C1113 NCI drug code

Drug Info:

Publications:

Wang et al., 2004, Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes., Biol. Reprod.

Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori

Edmiston et al., 1997, In vivo induction of murine cytokine production by carcinoembryonic antigen., Cancer Res.

DTC: GENISTEIN

Version: 02-September-2020

Alternate Names:

CHEMBL44 ChEMBL Drug ID

Drug Info:

Publications:

Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod

Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod

PharmGKB: genistein

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Arora K et al., 2016, Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation., Am J Physiol Lung Cell Mol Physiol

TTD: Genistein
- Version: 2020.06.01
Alternate Names:

D0L4FS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL44
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

GENISTEIN Drug Record

GENISTEIN chembl:CHEMBL44 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12820358

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15850105

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15229138

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9664138

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10330056

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10600647

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15527761

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9331108

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10400830

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 12124395 27261451

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9128187

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9712063

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621505

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17203194 14680578 12808286

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11698238

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10811979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16475902

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16203797

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17539658

Interaction Types & Directionality:

n/a

PMIDs:
12820358

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15850105

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15229138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9664138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10330056

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10600647

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15527761

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9331108

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10400830

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

PMIDs:
12124395 27261451

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9128187

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9712063

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8621505

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17203194 14680578 12808286

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11698238

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10811979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16475902

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16203797

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17539658

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10629745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11835393

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
10592235 17016423 17139284

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
7706371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16285913

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17375591

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12580099

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284 7769390