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GENTAMICIN Drug Record

  • Summary
  • Interactions
  • Claims
  • GENTAMICIN chembl:CHEMBL3039597 Approved

    Alternate Names:

    GENTAMICIN
    UROMYCINE
    SCH-9724

    Drug Info:

    (1 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Xie et al., Different type and localization of CD44 on surface membrane of regenerative renal tubular epithelial cells in vivo., Am. J. Nephrol.
    van der Harst et al., 2005, Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines., Vet. Res. Commun.
    Horibe et al., 2004, Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity., Biochem. Biophys. Res. Commun.
    Eti et al., 1993, Urinary clusterin in chronic nephrotoxicity in the rat., Proc. Soc. Exp. Biol. Med.
    Regec et al., 1986, The effect of gentamicin on human renal proximal tubular cells., Toxicol Pathol
    Oettinger et al., 2003, Microencapsulation of tumor necrosis factor oligomers: a new approach to proinflammatory cytokine inhibition., J. Interferon Cytokine Res.
    Martínez-Salgado et al., 1997, Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation., Am. J. Physiol.
    Stefanović et al., 1998, Kidney ectopeptidases in gentamicin and mercuric chloride-induced acute renal failure., Cell. Physiol. Biochem.
    Goto et al., 2004, Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats., Virchows Arch.
    Dominguez et al., 1996, Studies of renal injury. I. Gentamicin toxicity and expression of basolateral transporters., Am. J. Physiol.
    Ando et al., 1996, Induction of tissue transglutaminase in rat superior cervical sympathetic ganglia following in vitro stimulation of retinoic acid., Neurosci. Res.
    Verstrepen et al., 2001, Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat., Nephrol. Dial. Transplant.
    Priebe et al., 2008, IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa., J. Immunol.
    Suzuki et al., 2000, Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity., Gene Ther.
    Shohat M et al., 1999, Aminoglycoside-induced deafness associated with the mitochondrial DNA mutation A1555G., Am J Otolaryngol
    Tono T et al., 1998, Cochlear implantation in a patient with profound hearing loss with the A1555G mitochondrial mutation., Am J Otol
    Casano RA et al., 1998, Hearing loss due to the mitochondrial A1555G mutation in Italian families., Am J Med Genet
    Fischel-Ghodsian N et al., 1997, Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity., Am J Otolaryngol
    Usami S et al., 1997, Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation., Laryngoscope
    Fischel-Ghodsian N et al., 1993, Mitochondrial ribosomal RNA gene mutation in a patient with sporadic aminoglycoside ototoxicity., Am J Otolaryngol
    Prezant TR et al., 1993, Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness., Nat Genet
    Abusamra R et al., 2016, Is deafness mutation screening required in cystic fibrosis patients?, Paediatr Respir Rev
    Ding Y et al., 2016, Allele-specific PCR for detecting the deafness-associated mitochondrial 12S rRNA mutations., Gene
    Jing W et al., 2015, Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis., J Med Genet
    Al-Malky G et al., 2014, Normal hearing in a child with the m.1555A>G mutation despite repeated exposure to aminoglycosides. Has the penetrance of this pharmacogenetic interaction been overestimated?, Int J Pediatr Otorhinolaryngol
    Shen SS et al., 2012, Heteroplasmy levels of mtDNA1555A>G mutation is positively associated with diverse phenotypes and mutation transmission in a Chinese family., Biochem Biophys Res Commun
    Men M et al., 2011, Unique penetrance of hearing loss in a five-generation Chinese family with the mitochondrial 12S rRNA 1555A > G mutation., Acta Otolaryngol
    Ealy M et al., 2011, The prevalence of mitochondrial mutations associated with aminoglycoside-induced sensorineural hearing loss in an NICU population., Laryngoscope
    Johnson RF et al., 2010, Genetic mutations and aminoglycoside-induced ototoxicity in neonates., Otolaryngol Head Neck Surg
    Rydzanicz M et al., 2010, Mutation analysis of mitochondrial 12S rRNA gene in Polish patients with non-syndromic and aminoglycoside-induced hearing loss., Biochem Biophys Res Commun
    Kato T et al., 2010, Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss., J Hum Genet
    Zhu Y et al., 2009, Mitochondrial haplotype and phenotype of 13 Chinese families may suggest multi-original evolution of mitochondrial C1494T mutation., Mitochondrion
    Ding Y et al., 2009, Mitochondrial tRNA(Glu) A14693G variant may modulate the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in a Han Chinese family., J Genet Genomics
    Conrad DJ et al., 2008, Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population., Pharmacogenet Genomics
    Konings A et al., 2008, Mutation analysis of mitochondrial DNA 12SrRNA and tRNASer(UCN) genes in non-syndromic hearing loss patients., Mitochondrion
    Ballana E et al., 2008, Detection of unrecognized low-level mtDNA heteroplasmy may explain the variable phenotypic expressivity of apparently homoplasmic mtDNA mutations., Hum Mutat
    Yuan H et al., 2007, Coexistence of mitochondrial 12S rRNA C1494T and CO1/tRNA(Ser(UCN)) G7444A mutations in two Han Chinese pedigrees with aminoglycoside-induced and non-syndromic hearing loss., Biochem Biophys Res Commun
    Lévêque M et al., 2007, Whole mitochondrial genome screening in maternally inherited non-syndromic hearing impairment using a microarray resequencing mitochondrial DNA chip., Eur J Hum Genet
    Han D et al., 2007, The mitochondrial tRNA(Ala) T5628C variant may have a modifying role in the phenotypic manifestation of the 12S rRNA C1494T mutation in a large Chinese family with hearing loss., Biochem Biophys Res Commun
    Tang X et al., 2007, Very low penetrance of hearing loss in seven Han Chinese pedigrees carrying the deafness-associated 12S rRNA A1555G mutation., Gene
    Young WY et al., 2006, Variants in mitochondrial tRNAGlu, tRNAArg, and tRNAThr may influence the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in three Han Chinese families with hearing loss., Am J Med Genet A
    Dai P et al., 2006, Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA T1095C mutation in three Chinese families., Biochem Biophys Res Commun
    Bravo O et al., 2006, Cochlear alterations in deaf and unaffected subjects carrying the deafness-associated A1555G mutation in the mitochondrial 12S rRNA gene., Biochem Biophys Res Commun
    Ballana E et al., 2006, Mitochondrial 12S rRNA gene mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment., Biochem Biophys Res Commun
    Wang Q et al., 2006, Clinical and molecular analysis of a four-generation Chinese family with aminoglycoside-induced and nonsyndromic hearing loss associated with the mitochondrial 12S rRNA C1494T mutation., Biochem Biophys Res Commun
    Dai P et al., 2006, Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: implication for early detection and prevention of deafness., Biochem Biophys Res Commun
    Zhao L et al., 2005, Clinical evaluation and mitochondrial DNA sequence analysis in two Chinese families with aminoglycoside-induced and non-syndromic hearing loss., Biochem Biophys Res Commun
    Kobayashi K et al., 2005, Genetic features, clinical phenotypes, and prevalence of sensorineural hearing loss associated with the 961delT mitochondrial mutation., Auris Nasus Larynx
    Young WY et al., 2005, Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation., Biochem Biophys Res Commun
    Zhao L et al., 2004, Clinical evaluation and sequence analysis of the complete mitochondrial genome of three Chinese patients with hearing impairment associated with the 12S rRNA T1095C mutation., Biochem Biophys Res Commun
    Noguchi Y et al., 2004, Audiovestibular findings in patients with mitochondrial A1555G mutation., Laryngoscope
    Li R et al., 2004, Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss., Am J Med Genet A
    Yamasoba T et al., 2002, Atypical muscle pathology and a survey of cis-mutations in deaf patients harboring a 1555 A-to-G point mutation in the mitochondrial ribosomal RNA gene., Neuromuscul Disord
    Kupka S et al., 2002, Mutation A1555G in the 12S rRNA gene and its epidemiological importance in German, Hungarian, and Polish patients., Hum Mutat
    Tessa A et al., 2001, Maternally inherited deafness associated with a T1095C mutation in the mDNA., Eur J Hum Genet
    Tono T et al., 2001, Different clinical characteristics of aminoglycoside-induced profound deafness with and without the 1555 A-->G mitochondrial mutation., ORL J Otorhinolaryngol Relat Spec
    Thyagarajan D et al., 2000, A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy., Ann Neurol
    Anderson et al., 1992, Biological activity of recombinant interleukin-2 in intravenous admixtures containing antibiotic, morphine sulfate, or total parenteral nutrient solution., Am J Hosp Pharm
    Popper et al., 1999, Expression of BDNF and TrkB mRNAs in the crista neurosensory epithelium and vestibular ganglia following ototoxic damage., Brain Res.
  • GENTAMICIN   MT-RNR1

    Interaction Score: 21.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9950117 9831149 9779807 9164619 9111378 8285309 7689389 27427311 27397648 25515069 24703164 22475488 21504270 21495045 20416460 20353758 20111055 19682603 19376484 18830133 18790089 17999439 17698030 17637808 17434445 17341440 16955413 16875663 16631122 16458854 16380089 16375862 16168391 15917167 15708009 15555598 14755216 14699607 12031626 11857751 11313749 11174059 11079536


    Sources:
    PharmGKB

  • GENTAMICIN   CALR

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15351734


    Sources:
    NCI

  • GENTAMICIN   CD44

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14967965


    Sources:
    NCI

  • GENTAMICIN   GDNF

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10871754


    Sources:
    NCI

  • GENTAMICIN   SPP1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11274264


    Sources:
    NCI

  • GENTAMICIN   HEXB

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8456116 2876489


    Sources:
    NCI

  • GENTAMICIN   PLA2G2A

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9249592


    Sources:
    NCI

  • GENTAMICIN   SLC2A1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8779884


    Sources:
    NCI

  • GENTAMICIN   ANPEP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9792955


    Sources:
    NCI

  • GENTAMICIN   IL17A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18802100


    Sources:
    NCI

  • GENTAMICIN   GGT1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15736857


    Sources:
    NCI

  • GENTAMICIN   TGM2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8861105


    Sources:
    NCI

  • GENTAMICIN   IL2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1598936


    Sources:
    NCI

  • GENTAMICIN   VEGFA

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14986132


    Sources:
    NCI

  • GENTAMICIN   BDNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10536212


    Sources:
    NCI

  • GENTAMICIN   TNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14565862


    Sources:
    NCI

  • GENTAMICIN   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GENTAMICIN   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GENTAMICIN   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GENTAMICIN   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GENTAMICIN   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: GENTAMICIN

    • Version: 14-September-2017

    Alternate Names:
    C519 NCI drug code

    Drug Info:

    Publications:
    van der Harst et al., 2005, Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines., Vet. Res. Commun.
    Dominguez et al., 1996, Studies of renal injury. I. Gentamicin toxicity and expression of basolateral transporters., Am. J. Physiol.
    Verstrepen et al., 2001, Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat., Nephrol. Dial. Transplant.

  • DTC: GENTAMICIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL3039597 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: gentamicin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Conrad DJ et al., 2008, Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population., Pharmacogenet Genomics
    Dai P et al., 2006, Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA T1095C mutation in three Chinese families., Biochem Biophys Res Commun
    Fischel-Ghodsian N et al., 1997, Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity., Am J Otolaryngol

  • TTD: Gentamicin

    • Version: 2020.06.01

    Alternate Names:
    D0L9UU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3039597

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21