DGIdb - GLIMEPIRIDE Drug Record

GLIMEPIRIDE chembl:CHEMBL1481 ApprovedImmunotherapy

Alternate Names:

AMARYL
HOE-490
GLIMEPIRIDE
NIDDARYL

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidiabetic
Year of Approval	1995
Drug Class	hypoglycemic agents

(4 More Sources)

Publications:

Müller et al., 1994, Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics., Biochim. Biophys. Acta
Kramer et al., 1995, The molecular interaction of sulfonylureas with beta-cell ATP-sensitive K(+)-channels., Diabetes Res. Clin. Pract.
Kramer et al., 1996, Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at beta-cells., Horm. Metab. Res.
Li Q et al., 2014, KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
Javorsky M et al., 2012, KCNJ11 gene E23K variant and therapeutic response to sulfonylureas., Eur J Intern Med
Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med
Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.
Song et al., 2001, Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Br. J. Pharmacol.
Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Proks et al., 2002, Sulfonylurea stimulation of insulin secretion., Diabetes
Müller et al., 2005, Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes., Biochem. Pharmacol.
Niemi M et al., 2002, Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes., Clin Pharmacol Ther
Suzuki K et al., 2006, Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes., Diabetes Res Clin Pract
Mori et al., 2004, Comparison of the effects of glimepiride and glibenclamide on adipose tissue tumour necrosis factor-alpha mRNA expression and cellularity., Diabetes Obes Metab

GLIMEPIRIDE KCNJ11

Interaction Score: 3.59

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Trial Name glimepiride,Amaryl

PMIDs:
25115353 24442125 22385882 16595597 11318841 12086984 11325810 12703060

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB
GLIMEPIRIDE KCNJ1

Interaction Score: 3.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rosiglitazone + glimepiride,Avandaryl

Novel drug target Established target

Trial Name glimepiride ,Amaryl

PMIDs:
17016423 17139284 12703060 12475777

Sources:
TdgClinicalTrial TEND
GLIMEPIRIDE ABCC8

Interaction Score: 2.73

Interaction Types & Directionality:

blocker (inhibitory)

inducer (activating)

Interaction Info:

Trial Name glimepiride,Amaryl

Novel drug target Established target

Trial Name rosiglitazone + glimepiride,Avandaryl

PMIDs:
8172912 8529521 8911984

Sources:
TdgClinicalTrial ChemblInteractions TTD
GLIMEPIRIDE IRS1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15710354

Sources:
NCI
GLIMEPIRIDE ABCC9

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GLIMEPIRIDE TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14686960

Sources:
NCI
GLIMEPIRIDE G6PD

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
GLIMEPIRIDE CYP2C9

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24442125 12235454 16325295

Sources:
PharmGKB

TEND: GLIMEPIRIDE
- Version: 01-August-2011
Alternate Names:

GLIMEPIRIDE Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1995

Publications:
TdgClinicalTrial: GLIMEPIRIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidiabetic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: GLIMEPIRIDE

Version: 14-September-2017

Alternate Names:

C29073 NCI drug code

Drug Info:

Publications:

Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.

Mori et al., 2004, Comparison of the effects of glimepiride and glibenclamide on adipose tissue tumour necrosis factor-alpha mRNA expression and cellularity., Diabetes Obes Metab

Müller et al., 2005, Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes., Biochem. Pharmacol.

PharmGKB: glimepiride

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol

Niemi M et al., 2002, Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes., Clin Pharmacol Ther

Suzuki K et al., 2006, Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes., Diabetes Res Clin Pract

TTD: Glimepiride
- Version: 2020.06.01
Alternate Names:

D0B2GI TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1481
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1481
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Glimepiride
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sulfonylurea receptor 1, Kir6.2 blocker
Direct Interaction	yes
Trial Name	glimepiride,Amaryl

Trial Name	rosiglitazone + glimepiride,Avandaryl
Novel drug target	Established target
Trial Name	glimepiride ,Amaryl

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inducer (activating)

GLIMEPIRIDE Drug Record

GLIMEPIRIDE chembl:CHEMBL1481 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes Trial Name glimepiride,Amaryl

PMIDs: 25115353 24442125 22385882 16595597 11318841 12086984 11325810 12703060

Sources: TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name rosiglitazone + glimepiride,Avandaryl Novel drug target Established target Trial Name glimepiride ,Amaryl

PMIDs: 17016423 17139284 12703060 12475777

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory) inducer (activating)

Interaction Info: Trial Name glimepiride,Amaryl Novel drug target Established target Trial Name rosiglitazone + glimepiride,Avandaryl

PMIDs: 8172912 8529521 8911984

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15710354

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14686960

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24442125 12235454 16325295

Sources: PharmGKB

TEND: GLIMEPIRIDE

Alternate Names: GLIMEPIRIDE Primary Drug Name

Drug Info: Drug Class hypoglycemic agents Year of Approval 1995

Publications:

TdgClinicalTrial: GLIMEPIRIDE

Alternate Names:

Drug Info: Drug Indications antidiabetic Drug Class Small Molecule FDA Approval approved

Publications:

NCI: GLIMEPIRIDE

Alternate Names: C29073 NCI drug code

Drug Info:

PharmGKB: glimepiride

Alternate Names:

Drug Info:

TTD: Glimepiride

Alternate Names: D0B2GI TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1481

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1481

Alternate Names:

Drug Info:

Publications:

FDA: Glimepiride

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Trial Name glimepiride,Amaryl

PMIDs:
25115353 24442125 22385882 16595597 11318841 12086984 11325810 12703060

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rosiglitazone + glimepiride,Avandaryl

Novel drug target Established target

Trial Name glimepiride ,Amaryl

PMIDs:
17016423 17139284 12703060 12475777

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

inducer (activating)

Interaction Info:

Trial Name glimepiride,Amaryl

Novel drug target Established target

Trial Name rosiglitazone + glimepiride,Avandaryl

PMIDs:
8172912 8529521 8911984

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
15710354

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
14686960

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
24442125 12235454 16325295

Sources:
PharmGKB

Alternate Names:

GLIMEPIRIDE Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1995

Drug Info:

Drug Indications antidiabetic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29073 NCI drug code

Alternate Names:

D0B2GI TTD Drug ID