DGIdb - GLIPIZIDE Drug Record

GLIPIZIDE chembl:CHEMBL1073 Approved

Alternate Names:

MINODIAB 2.5
CP-28720
GLUCOTROL
MINODIAB 5
GLUCOTROL XL
K-4024
GLIPIZIDE
GLIBENESE
GLIPIZIDA
N-{4-[Β-(5-METHYLPYRAZINE-2-CARBOXAMIDO)ETHYL]BENZENESULPHONYL}-N'-CYCLOHEXYLUREA
CP-28,720
CP 28,720
1-CYCLOHEXYL-3-({P-[2-(5-METHYLPYRAZINECARBOXAMIDO)ETHYL]PHENYL}SULFONYL)UREA
GLIPIZIDUM
K 4024
N-{4-[BETA-(5-METHYLPYRAZINE-2-CARBOXAMIDO)ETHYL]BENZENESULPHONYL}-N'-CYCLOHEXYLUREA
GLUCOTROL®
CP 28720
rxcui:4821
drugbank:01067
chembl:CHEMBL1073
pubchem.compound:3478
chemidplus:29094-61-9

Drug Info:

FDA Approval	1984
Drug Class	small molecule
Drug Indications	Hypoglycemic Agents
Drug Class	hypoglycemic agents
Year of Approval	1984

(4 More Sources)

Publications:

Li Q et al., 2014, KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
Javorsky M et al., 2012, KCNJ11 gene E23K variant and therapeutic response to sulfonylureas., Eur J Intern Med
Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med
Lawrence et al., 2001, Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells., Diabetologia
Reimann et al., 2001, Structural basis for the interference between nicorandil and sulfonylurea action., Diabetes
Gribble et al., 2000, Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues., Metab. Clin. Exp.
Harrower, 2000, Gliclazide modified release: from once-daily administration to 24-hour blood glucose control., Metab. Clin. Exp.
Proks et al., 2002, Sulfonylurea stimulation of insulin secretion., Diabetes
Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol
Kidd RS et al., 1999, Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele., Pharmacogenetics

GLIPIZIDE ABCC8

Interaction Score: 3.12

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs:
11484080 11574406 11078468 11078469 12475777

Sources:
ChemblInteractions
GLIPIZIDE KCNJ11

Interaction Score: 2.21

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
25115353 24442125 22385882 16595597 11318841

Sources:
ChemblInteractions PharmGKB
GLIPIZIDE KCNJ1

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
GLIPIZIDE KCNJ10

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GLIPIZIDE SLC2A4

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8043894

Sources:
NCI
GLIPIZIDE G6PD

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
GLIPIZIDE CYP2C9

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24442125 10208645

Sources:
PharmGKB

TEND: GLIPIZIDE
- Version: 01-August-2011
Alternate Names:

GLIPIZIDE Primary Drug Name

Drug Info:

Year of Approval 1984

Drug Class hypoglycemic agents

Publications:
TdgClinicalTrial: GLIPIZIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1984

Publications:

NCI: GLIPIZIDE

Version: 14-September-2017

Alternate Names:

C29074 NCI drug code

Drug Info:

Publications:

Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol

PharmGKB: glipizide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol

Kidd RS et al., 1999, Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele., Pharmacogenetics

Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab

TTD: Glipizide
- Version: 2020.06.01
Alternate Names:

D0Z4SB TTD Drug ID

Drug Info:

Publications:
FDA: Glipizide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1073
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1073
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Sulfonylurea receptor 1, Kir6.2 blocker

blocker (inhibitory)
inhibitor (inhibitory)

Trial Name	-
Novel drug target	Established target

GLIPIZIDE Drug Record

GLIPIZIDE chembl:CHEMBL1073 Approved

Alternate Names:

Drug Info:

Publications:

GLIPIZIDE ABCC8

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs: 11484080 11574406 11078468 11078469 12475777

Sources: ChemblInteractions

GLIPIZIDE KCNJ11

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: 25115353 24442125 22385882 16595597 11318841

Sources: ChemblInteractions PharmGKB

GLIPIZIDE KCNJ1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

GLIPIZIDE KCNJ10

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

GLIPIZIDE SLC2A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8043894

Sources: NCI

GLIPIZIDE G6PD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

GLIPIZIDE CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24442125 10208645

Sources: PharmGKB

TEND: GLIPIZIDE

Alternate Names: GLIPIZIDE Primary Drug Name

Drug Info: Year of Approval 1984 Drug Class hypoglycemic agents

Publications:

TdgClinicalTrial: GLIPIZIDE

Alternate Names:

Drug Info: Drug Indications Hypoglycemic Agents Drug Class small molecule FDA Approval 1984

Publications:

NCI: GLIPIZIDE

Alternate Names: C29074 NCI drug code

Drug Info:

Publications: Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol

PharmGKB: glipizide

Alternate Names:

Drug Info:

TTD: Glipizide

Alternate Names: D0Z4SB TTD Drug ID

Drug Info:

Publications:

FDA: Glipizide

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1073

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1073

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs:
11484080 11574406 11078468 11078469 12475777

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
25115353 24442125 22385882 16595597 11318841

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8043894

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
24442125 10208645

Sources:
PharmGKB

Alternate Names:

GLIPIZIDE Primary Drug Name

Drug Info:

Year of Approval 1984

Drug Class hypoglycemic agents

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1984

Alternate Names:

C29074 NCI drug code

Publications:

Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol

Alternate Names:

D0Z4SB TTD Drug ID