DGIdb - GLUTAMIC ACID Drug Record

GLUTAMIC ACID chembl:CHEMBL575060

Alternate Names:

FEMA NO. 3285
L-GLUTAMIC ACID
INS-620
GLUTAMIC ACID
E-620
E 620
INS NO.620
E620
NSC-143503
L-GLUTAMATE

Drug Info:

Drug Categories	glutamates
Drug Categories	amino acids, acidic
Drug Categories	gastrointestinal agents
Drug Categories	digestives, incl. enzymes
Drug Categories	alimentary tract and metabolism
Drug Categories	acid preparations
Drug Groups	approved

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Publications:

Resto M et al., 2009, An ancestral glutamine-dependent NAD(+) synthetase revealed by poor kinetic synergism., Biochim Biophys Acta
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Xu et al., 2007, Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms., Microbiol. Mol. Biol. Rev.
Boehlein SK et al., 1996, Glutamic acid gamma-monohydroxamate and hydroxylamine are alternate substrates for Escherichia coli asparagine synthetase B., Biochemistry
Bresink et al., 1996, Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells., Br. J. Pharmacol.
Rutter et al., 2002, Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating., J. Neurochem.
Rutter et al., 2000, Coexpression of postsynaptic density-95 protein with NMDA receptors results in enhanced receptor expression together with a decreased sensitivity to L-glutamate., J. Neurochem.
Cerini et al., 1997, Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex., Eur. J. Biochem.
Ting et al., 1994, Post-transcriptional regulation of glutamyl-prolyl-tRNA synthetase in rat salivary gland., J. Biol. Chem.
Gaziola et al., 1997, The enzymology of lysine catabolism in rice seeds--isolation, characterization, and regulatory properties of a lysine 2-oxoglutarate reductase/saccharopine dehydrogenase bifunctional polypeptide., Eur. J. Biochem.
Noda et al., 1978, Purification and properties of L-lysine-alpha-ketoglutarate reductase from rat liver mitochondria., Biochim. Biophys. Acta
Goncalves-Butruille et al., 1996, Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize., Plant Physiol.
Verkhratsky et al., 2007, NMDA Receptors in glia., Neuroscientist
Miglio et al., 2007, Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin., Biochem. Biophys. Res. Commun.
Henley et al., 1993, Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord., Neuropharmacology
Nishimura et al., 2001, A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity)., Biosci. Biotechnol. Biochem.
Seddon et al., 1984, Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein., J. Biol. Chem.
Van der Werf et al., 1973, Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid., Proc. Natl. Acad. Sci. U.S.A.
Nickell et al., 2007, Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum., Neurobiol. Aging
Glowatzki et al., 2006, The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea., J. Neurosci.
Beart et al., 2007, Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement., Br. J. Pharmacol.
Kita et al., 2007, Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents., Toxicol. Appl. Pharmacol.
Yoshimune et al., 2006, Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3., Biochem. Biophys. Res. Commun.
Dossena et al., 2007, Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain., Biochemistry
Takeda et al., 2000, Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells., Neurosci. Lett.
Bettler et al., 1992, Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit., Neuron
Stühmer et al., 1996, Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior., J. Neurosci.
Hutson SM et al., 1998, Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism., J Neurochem
Ola MS et al., 2011, Influence of insulin on glutamine synthetase in the Müller glial cells of retina., Metab Brain Dis
Sekine et al., 2006, Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase., Structure
Ozturk et al., 2006, Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1., J. Endocrinol. Invest.
Far et al., 1996, Levels of glutamic acid decarboxylase (GAD), gamma amino butyric acid transaminase (GABA-T), glutamic acid dehydrogenase (GLDH) and proteins in cerebrospinal fluid of certain neurological disorders., Indian J Med Sci
Imai et al., 1991, GABAergic innervation in cerebral blood vessels: an immunohistochemical demonstration of L-glutamic acid decarboxylase and GABA transaminase., J. Cereb. Blood Flow Metab.
Häppölä et al., 1987, Localization of L-glutamate decarboxylase and GABA transaminase immunoreactivity in the sympathetic ganglia of the rat., Neuroscience
Natale et al., 2006, Can selective ligands for glutamate binding proteins be rationally designed?, Curr Top Med Chem
King et al., 2006, Expression and activity of the glutamate transporter EAAT2 in cardiac hypertrophy: implications for ischaemia reperfusion injury., Pflugers Arch.
Arriza et al., 1997, Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance., Proc. Natl. Acad. Sci. U.S.A.
Takarada et al., 2004, Possible expression of functional glutamate transporters in the rat testis., J. Endocrinol.
Ohgami et al., 2007, Determination of the activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in a microfluidic system., Biosens Bioelectron
Rodriguez et al., 2001, Inhibition of glutamate carboxypeptidase II by phosphonamidothionate derivatives of glutamic acid., J. Enzym. Inhib.
Maung et al., 2004, Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates., Bioorg. Med. Chem.
Davis et al., 2005, Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase., Proc. Natl. Acad. Sci. U.S.A.
Akama et al., 2007, C-terminal extension of rice glutamate decarboxylase (OsGAD2) functions as an autoinhibitory domain and overexpression of a truncated mutant results in the accumulation of extremely high levels of GABA in plant cells., J. Exp. Bot.
Tueting et al., 2006, Reelin down-regulation in mice and psychosis endophenotypes., Neurosci Biobehav Rev
Manto et al., 2007, Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases., Ann. Neurol.
Wang et al., 2006, Expression of gamma-aminobutyric acid and glutamic acid decarboxylases in rat descending colon and their relation to epithelial differentiation., Chin J Dig Dis
Tronci et al., 2007, Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats., Eur. J. Pharmacol.
Yudkoff et al., 2007, The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect., Annu. Rev. Nutr.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Recasens et al., 1979, Similarities between cysteinesulphinate transaminase and aspartate aminotransferase., Ciba Found. Symp.
Kocki et al., 2003, L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II., Neurosci. Lett.
Yun et al., 2007, Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement., Eur. J. Pharmacol.
Tao et al., 2007, Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1., J. Gen. Physiol.
Menaker et al., 2006, The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion., J. Neurochem.
Cheng Q et al., 2005, Evolution of glutamate interactions during binding to a glutamate receptor., Nat Chem Biol
Stein et al., 1992, Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes., Mol. Pharmacol.
Li et al., 1995, Functional effects of mutations in the putative agonist binding region of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors., Mol. Pharmacol.
Suzuki et al., 2007, Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)., J. Pharmacol. Exp. Ther.
Cristóvão et al., 2002, Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies., Int. J. Dev. Neurosci.
Lindén et al., 2001, Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors., Neuropharmacology
Spanaki C et al., 2016, Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons., Mol Neurobiol
Mastorodemos V et al., 2009, Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum., Biochem Cell Biol
Zaganas I et al., 2012, Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications., Neurochem Int
Acartürk et al., 2001, Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans., J. Pharm. Pharmacol.
Tobe et al., 1980, Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney., Biochim. Biophys. Acta
Sasaki et al., 1995, Comparison of proteolytic activities in various lactobacilli., J. Dairy Res.
Watanabe et al., 2007, Characterization of Aspergillus oryzae aspartyl aminopeptidase expressed in Escherichia coli., Biosci. Biotechnol. Biochem.
Giordano et al., 2006, Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency., Mol. Pharmacol.
Scaraffia et al., 2006, Analysis of whole body ammonia metabolism in Aedes aegypti using [15N]-labeled compounds and mass spectrometry., Insect Biochem. Mol. Biol.
Singh et al., 2006, Development of a simple high-throughput screening protocol based on biosynthetic activity of Mycobacterium tuberculosis glutamine synthetase for the identification of novel Inhibitors., J Biomol Screen
Yamamoto et al., 2007, Characterization of theanine-forming enzyme from Methylovorus mays no. 9 in respect to utilization of theanine production., Biosci. Biotechnol. Biochem.
Re et al., 2006, Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport., Glia
Ravasio et al., 2002, Properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803. Comparison with the Azospirillum brasilense NADPH-dependent enzyme and its isolated alpha subunit., Biochemistry
Myers et al., 2005, Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase., Biochemistry
Boehlein et al., 1994, Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad., J. Biol. Chem.
Zhu et al., 2007, Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase., Blood
Lal et al., 2006, Pharmacogenetics of target genes across the warfarin pharmacological pathway., Clin Pharmacokinet
Lu SC, 2013, Glutathione synthesis., Biochim Biophys Acta
Anagnou et al., Chromosomal mapping of two members of the human glutamate dehydrogenase (GLUD) gene family to chromosomes 10q22.3-q23 and Xq22-q23., Hum. Hered.
Morimoto et al., 2006, Secretion of L-glutamate from osteoclasts through transcytosis., EMBO J.
Wong et al., 2007, Na+/Cl- dipole couples agonist binding to kainate receptor activation., J. Neurosci.
Valgeirsson et al., 2003, Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues., Bioorg. Med. Chem.
Sahara et al., 1997, Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons., J. Neurosci.
Stensbøl et al., 1999, Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA., Eur. J. Pharmacol.
Smirnov et al., 2007, A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity., FEMS Microbiol. Lett.
Sundström et al., 1997, Analysis of NMDA receptors in the human spinal cord., Exp. Neurol.
Kuner et al., 1993, Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes., Neuroreport
Olmos et al., 1999, Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor., Br. J. Pharmacol.
Jayaram et al., 1990, Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride., Cancer Chemother. Pharmacol.
Pop et al., 2007, The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice., Diabetes
Wei et al., 2006, Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain., J. Neurochem.
Castelli et al., 2007, Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studies., Neuroscience
DeMartino et al., 2006, Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase., J. Med. Chem.
Gangjee et al., 2006, Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates., Bioorg. Med. Chem.
Korczak et al., 1995, cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration., Recept. Channels
Kimmich GA et al., 2002, Aspartate aminotransferase isotope exchange reactions: implications for glutamate/glutamine shuttle hypothesis., Am J Physiol Cell Physiol
Toney MD, 2014, Aspartate aminotransferase: an old dog teaches new tricks., Arch Biochem Biophys
Ouyang Q et al., 2016, Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features., Proc Natl Acad Sci U S A
McAllister CH et al., 2015, Alanine aminotransferase variants conferring diverse NUE phenotypes in Arabidopsis thaliana., PLoS One
Mu X et al., 2012, Study on alanine aminotransferase kinetics by microchip electrophoresis., Anal Biochem
Murphy et al., 1988, Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain., Br. J. Pharmacol.
Yao Y et al., 2006, Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A., J Neurosci
Katsura et al., 2004, Crystal structure of a putative aspartate aminotransferase belonging to subgroup IV., Proteins
Hester et al., 1999, Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate., J. Mol. Biol.
Gegelashvili et al., 1997, High affinity glutamate transporters: regulation of expression and activity., Mol. Pharmacol.
Lin et al., 1998, Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype., Brain Res. Mol. Brain Res.
Morita et al., 2003, L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase., Appl. Environ. Microbiol.
Krishna et al., 1979, Biosynthesis of proline in Pseudomonas aeruginosa. Properties of gamma-glutamyl phosphate reductase and 1-pyrroline-5-carboxylate reductase., Biochem. J.
Kamoun et al., 1998, [A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency]., Bull. Acad. Natl. Med.
Gao et al., 1998, Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein., J. Biol. Chem.
Pliss et al., 2002, N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier., Neurosci. Lett.
San Gabriel et al., 2007, mGluR1 in the fundic glands of rat stomach., FEBS Lett.
Chiocchetti et al., 2006, Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes., Br. J. Pharmacol.
Karmaker et al., 2006, A novel drug delivery system for type 1 diabetes: insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex., J. Inorg. Biochem.
Shi et al., 2006, Efficient production of poly-gamma-glutamic acid by Bacillus subtilis ZJU-7., Appl. Biochem. Biotechnol.
Ashiuchi et al., 2006, Novel poly-gamma-glutamate-processing enzyme catalyzing gamma-glutamyl DD-amidohydrolysis., J. Biosci. Bioeng.
Ashiuchi et al., 2006, Genetically engineered poly-gamma-glutamate producer from Bacillus subtilis ISW1214., Biosci. Biotechnol. Biochem.
Yang et al., 2006, A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor., J. Pharmacol. Exp. Ther.

GLUTAMIC ACID ALDH18A1

Interaction Score: 5.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12513997 114173 17139284 17016423 9622938

Sources:
DrugBank
GLUTAMIC ACID GMPS

Interaction Score: 5.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12069605 17139284 16142895 17016423 7907328

Sources:
DrugBank
GLUTAMIC ACID SLC1A6

Interaction Score: 4.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9224806 9838098 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID SLC1A7

Interaction Score: 4.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9108121 15128272 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID PFAS

Interaction Score: 3.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2347042 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID CPQ

Interaction Score: 3.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GLS2

Interaction Score: 3.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17321558 16793004 17373776

Sources:
DrugBank
GLUTAMIC ACID SLC1A3

Interaction Score: 3.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16959378 16855093 17088867

Sources:
DrugBank
GLUTAMIC ACID NADSYN1

Interaction Score: 3.61

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
19647806 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID ENPEP

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11732752 7448199 8568030 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GLUD2

Interaction Score: 2.71

Interaction Types & Directionality:

substrate

Interaction Info:

PMIDs:
26399640 19448744 22709674 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID OPLAH

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11302195 6145710 17139284 17016423 4514988

Sources:
DrugBank
GLUTAMIC ACID PSAT1

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15103612 17139284 17016423 10024454

Sources:
DrugBank
GLUTAMIC ACID GLUL

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16876704 16973920 17284842 16673373

Sources:
DrugBank
GLUTAMIC ACID GAD2

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17317763 17600364 16643338 16879709 17507169

Sources:
DrugBank
GLUTAMIC ACID DNPEP

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17928682 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID AADAT

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 12850557

Sources:
DrugBank
GLUTAMIC ACID GAD1

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17562689 16769115 17600364 16643338 17445798

Sources:
DrugBank
GLUTAMIC ACID EARS2

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17161369

Sources:
DrugBank
GLUTAMIC ACID AASS

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9249048 687635 17139284 17016423 12226216

Sources:
DrugBank
GLUTAMIC ACID NAGS

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17347518

Sources:
DrugBank
GLUTAMIC ACID SLC1A2

Interaction Score: 1.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16718509 16959378 16855093 17088867

Sources:
DrugBank
GLUTAMIC ACID GPT2

Interaction Score: 1.35

Interaction Types & Directionality:

product of

substrate

Interaction Info:

PMIDs:
27601654 25830496 22200652 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GRM8

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360958 16957773

Sources:
DrugBank
GLUTAMIC ACID FTCD

Interaction Score: 1.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9837973 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIK5

Interaction Score: 1.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11058796 2850065 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GOT2

Interaction Score: 1.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 261660 17016423

Sources:
DrugBank
GLUTAMIC ACID GRM7

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360958

Sources:
DrugBank
GLUTAMIC ACID GRIK3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11058796 1371217 8622118 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIK1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
13129570 9254673 17139284 17016423 10513575

Sources:
DrugBank
GLUTAMIC ACID PCAP

Interaction Score: 0.75

Interaction Types & Directionality:

product of

substrate

Interaction Info:

PMIDs:
11997255 24121043 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID BCAT2

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9681479 21626103 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID EPRS

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 9063462 8132637

Sources:
DrugBank
GLUTAMIC ACID GLUD1

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8288265 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID ASNS

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8608142 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GCLC

Interaction Score: 0.6

Interaction Types & Directionality:

substrate

Interaction Info:

PMIDs:
17139284 17016423 22995213

Sources:
DrugBank
GLUTAMIC ACID SLC1A1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17382927 16959378 17389249 16831195

Sources:
DrugBank
GLUTAMIC ACID FPGS

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16686541 16990006

Sources:
DrugBank
GLUTAMIC ACID GRM1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360958 17331504 16751798

Sources:
DrugBank
GLUTAMIC ACID GRIK4

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8589992 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GGCX

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17327402 17112295

Sources:
DrugBank
GLUTAMIC ACID ABAT

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8979623 17139284 17016423 1983997 3299141

Sources:
DrugBank
GLUTAMIC ACID FOLH1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11916141 15336276 15837926 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GCLM

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17000861

Sources:
DrugBank
GLUTAMIC ACID BCAT1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17559390

Sources:
DrugBank
GLUTAMIC ACID GPT

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16854580

Sources:
DrugBank
GLUTAMIC ACID GOT1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17444813

Sources:
DrugBank
GLUTAMIC ACID SLC7A11

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16719820

Sources:
DrugBank
GLUTAMIC ACID GRIA4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12008069 7679210 17139284 11406192 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIA1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1279377 7679210 17139284 17016423 7838123

Sources:
DrugBank
GLUTAMIC ACID GRM4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360958

Sources:
DrugBank
GLUTAMIC ACID GRIA2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16408071 1279377 7679210 17139284 17016423 7838123

Sources:
DTC DrugBank
GLUTAMIC ACID GRIN2D

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9417820 8886398 11755246 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIN2C

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9417820 7905294 10455281 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID TAT

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16840830

Sources:
DrugBank
GLUTAMIC ACID GRIN2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8886398 12068077 17139284 17016423 11080203

Sources:
DrugBank
GLUTAMIC ACID GRIA3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7679210 17139284 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIN3A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 16641235 17016423

Sources:
DrugBank
GLUTAMIC ACID GRIK2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17581967

Sources:
DrugBank
GLUTAMIC ACID GLS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16824605 16720907 16952838 16861819 16815871

Sources:
DrugBank
GLUTAMIC ACID GRIN2B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17229973 17662248

Sources:
DrugBank
GLUTAMIC ACID GRIN1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17662248

Sources:
DrugBank
GLUTAMIC ACID EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00142

Version: 5.1.7

Alternate Names:

56-86-0 CAS Number

20% Prosol Drug Brand

Aminosyn II 7% M In 10% Dextrose(dual Chamber) Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Publications:

Suzuki et al., 2007, Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)., J. Pharmacol. Exp. Ther.

San Gabriel et al., 2007, mGluR1 in the fundic glands of rat stomach., FEBS Lett.

Chiocchetti et al., 2006, Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes., Br. J. Pharmacol.

DTC: L-GLUTAMATE
- Version: 02-September-2020
Alternate Names:

CHEMBL575060 ChEMBL Drug ID

Drug Info:

Publications:

Cheng Q et al., 2005, Evolution of glutamate interactions during binding to a glutamate receptor., Nat Chem Biol
ChemblDrugs: chembl:CHEMBL575060
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

56-86-0	CAS Number
20% Prosol	Drug Brand
Aminosyn II 7% M In 10% Dextrose(dual Chamber)	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	nutraceutical

GLUTAMIC ACID Drug Record

GLUTAMIC ACID chembl:CHEMBL575060

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12513997 114173 17139284 17016423 9622938

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12069605 17139284 16142895 17016423 7907328

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9224806 9838098 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9108121 15128272 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2347042 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17321558 16793004 17373776

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16959378 16855093 17088867

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 19647806 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11732752 7448199 8568030 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: substrate

Interaction Info:

PMIDs: 26399640 19448744 22709674 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11302195 6145710 17139284 17016423 4514988

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15103612 17139284 17016423 10024454

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16876704 16973920 17284842 16673373

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17317763 17600364 16643338 16879709 17507169

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17928682 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 12850557

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17562689 16769115 17600364 16643338 17445798

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17161369

Interaction Types & Directionality:

n/a

PMIDs:
12513997 114173 17139284 17016423 9622938

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12069605 17139284 16142895 17016423 7907328

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9224806 9838098 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9108121 15128272 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
2347042 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17321558 16793004 17373776

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16959378 16855093 17088867

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
19647806 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11732752 7448199 8568030 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

substrate

PMIDs:
26399640 19448744 22709674 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11302195 6145710 17139284 17016423 4514988

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15103612 17139284 17016423 10024454

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16876704 16973920 17284842 16673373

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17317763 17600364 16643338 16879709 17507169

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17928682 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 12850557

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17562689 16769115 17600364 16643338 17445798

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17161369

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9249048 687635 17139284 17016423 12226216

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17347518

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16718509 16959378 16855093 17088867

Sources:
DrugBank

Interaction Types & Directionality:

product of

substrate

PMIDs:
27601654 25830496 22200652 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17360958 16957773

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9837973 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11058796 2850065 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 261660 17016423