DGIdb - GRANISETRON Drug Record

GRANISETRON chembl:CHEMBL289469 ApprovedAntineoplastic

Alternate Names:

KYTRIL
APF530
APF-530
SANCUSO
SUSTOL
BRL-43694
GRANISETRON
LY-278584
SID90340785
BRL 43694
rxcui:26237
drugbank:00889
chembl:CHEMBL289469
chemidplus:109889-09-0

Drug Info:

Drug Class	antiemetics
Year of Approval	1993
FDA Approval	not approved
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiemetic

(3 More Sources)

Publications:

Janicki PK et al., 2006, Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype., Anesth Analg
Yokoi M et al., 2018, Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy., Support Care Cancer
Tsuji D et al., 2017, Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study., Pharmacogenomics J
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Bustos ML et al., 2016, Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting., Pharmacotherapy
Abdelsayed, 2007, Management of radiation-induced nausea and vomiting., Exp. Hematol.
Cappelli et al., 2002, Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities., Bioorg. Med. Chem.
Turvill et al., 2000, The inhibition of cholera toxin-induced 5-HT release by the 5-HT(3) receptor antagonist, granisetron, in the rat., Br. J. Pharmacol.
Tan, 2003, Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting., Expert Opin Pharmacother
Hillsley et al., 1999, Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat., J. Auton. Nerv. Syst.
Ho et al., 2006, Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting., Curr Opin Anaesthesiol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Feyer et al., 2005, Granisetron in the control of radiotherapy-induced nausea and vomiting: a comparison with other antiemetic therapies., Support Care Cancer
Gan, 2005, Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same?, CNS Drugs
Quraishi SA et al., 2011, 5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities., J Clin Anesth

GRANISETRON NOS1AP

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21663814

Sources:
PharmGKB
GRANISETRON HTR3A

Interaction Score: 1.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist

Direct Interaction yes

Trial Name APF530, granisetron

PMIDs:
17379085 11814868 10882387 12943486 10412832 17093363 11752352 16044252 15740177

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
GRANISETRON HTR3C

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial
GRANISETRON HTR3D

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial
GRANISETRON HTR3E

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron (intranasal), TRG

Novel drug target Established target

Trial Name granisetron nasal spray

PMIDs:
None found

Sources:
TdgClinicalTrial
GRANISETRON ERCC1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29177570

Sources:
PharmGKB
GRANISETRON CYP1A1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27809336

Sources:
PharmGKB
GRANISETRON HTR3B

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial
GRANISETRON CYP3A5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27809336

Sources:
PharmGKB
GRANISETRON ABCB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29177570 27241063

Sources:
PharmGKB
GRANISETRON CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16551910

Sources:
PharmGKB
GRANISETRON TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
GRANISETRON CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: GRANISETRON
- Version: 01-August-2011
Alternate Names:

GRANISETRON Primary Drug Name

Drug Info:

Year of Approval 1993

Drug Class antiemetics

Publications:
TdgClinicalTrial: GRANISETRON
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiemetic

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: granisetron

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Yokoi M et al., 2018, Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy., Support Care Cancer

Tsuji D et al., 2017, Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study., Pharmacogenomics J

Quraishi SA et al., 2011, 5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities., J Clin Anesth

TTD: Granisetron
- Version: 2020.06.01
Alternate Names:

D0J5KF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL289469
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL289469
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ClearityFoundationClinicalTrial: GRANISETRON
- Version: 15-June-2013
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Serotonin 3a (5-HT3a) receptor antagonist
Direct Interaction	yes
Trial Name	APF530, granisetron

Trial Name	granisetron nasal spray
Novel drug target	Established target
Trial Name	granisetron (intranasal), TRG

GRANISETRON Drug Record

GRANISETRON chembl:CHEMBL289469 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21663814

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist Direct Interaction yes Trial Name APF530, granisetron

PMIDs: 17379085 11814868 10882387 12943486 10412832 17093363 11752352 16044252 15740177

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name granisetron nasal spray Novel drug target Established target Trial Name granisetron (intranasal), TRG

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name granisetron nasal spray Novel drug target Established target Trial Name granisetron (intranasal), TRG

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name granisetron (intranasal), TRG Novel drug target Established target Trial Name granisetron nasal spray

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29177570

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27809336

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name granisetron nasal spray Novel drug target Established target Trial Name granisetron (intranasal), TRG

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27809336

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29177570 27241063

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16551910

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: GRANISETRON

Alternate Names: GRANISETRON Primary Drug Name

Drug Info: Year of Approval 1993 Drug Class antiemetics

Publications:

TdgClinicalTrial: GRANISETRON

Alternate Names:

Drug Info: Drug Indications antiemetic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: granisetron

Alternate Names:

Drug Info:

TTD: Granisetron

Alternate Names: D0J5KF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL289469

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL289469

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21663814

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 3a (5-HT3a) receptor antagonist

Direct Interaction yes

Trial Name APF530, granisetron

PMIDs:
17379085 11814868 10882387 12943486 10412832 17093363 11752352 16044252 15740177

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron (intranasal), TRG

Novel drug target Established target

Trial Name granisetron nasal spray

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
29177570

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27809336

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name granisetron nasal spray

Novel drug target Established target

Trial Name granisetron (intranasal), TRG

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
27809336

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29177570 27241063

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16551910

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

GRANISETRON Primary Drug Name

Drug Info:

Year of Approval 1993

Drug Class antiemetics

Drug Info:

Drug Indications antiemetic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0J5KF TTD Drug ID