• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

HEXOBARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • HEXOBARBITAL chembl:CHEMBL7728

    Alternate Names:

    HEXOBARBITAL
    SOMBULEX
    SOMBUCAPS
    EVIPAL
    ENHEXYMAL
    METHEXENYL
    METHYLHEXABITAL
    EVIPAN
    5-CYCLOHEX-1-ENYL-1,5-DIMETHYL-PYRIMIDINE-2,4,6-TRIONE
    5-(1-CYCLOHEXEN-1-YL)-1,5-DIMETHYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    5-(1-CYCLOHEXEN-1-YL)-1,5-DIMETHYLBARBITURIC ACID
    HEXOBARBITONE
    rxcui:5302
    pubchem.compound:3608
    chemidplus:56-29-1
    chembl:CHEMBL7728
    drugbank:01355

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Year of Approval approved before 1982
    Drug Class hypnotics and sedatives
    Drug Groups experimental
    Drug Categories anesthetics
    Drug Categories anesthetics, general
    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories nicotinic antagonists
    (1 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Tomlin et al., 1999, Preparation of barbiturate optical isomers and their effects on GABA(A) receptors., Anesthesiology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • HEXOBARBITAL   GRIK2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   CHRNA4

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GRIA2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14579514 10360871 11264449 11752352 17139284 10209232 17016423 10487207


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • HEXOBARBITAL   CHRNA7

    Interaction Score: 0.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA6

    Interaction Score: 0.36

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA5

    Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA3

    Interaction Score: 0.32

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GABRA4

    Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DrugBank: DB01355

    • Version: 5.1.7

    Alternate Names:
    HEXOBARBITAL DrugBank Drug Name
    56-29-1 CAS Number
    Citopan Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Categories adjuvants

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.

  • TEND: HEXOBARBITAL

    • Version: 01-August-2011

    Alternate Names:
    HEXOBARBITAL Primary Drug Name

    Drug Info:
    Drug Class hypnotics and sedatives
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: HEXOBARBITAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TTD: Hexobarbital

    • Version: 2020.06.01

    Alternate Names:
    D00ETS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL7728

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21