DGIdb - HEXOBARBITAL Drug Record

HEXOBARBITAL chembl:CHEMBL7728

Alternate Names:

HEXOBARBITAL
SOMBULEX
SOMBUCAPS
EVIPAL
ENHEXYMAL
METHEXENYL
METHYLHEXABITAL
EVIPAN
5-CYCLOHEX-1-ENYL-1,5-DIMETHYL-PYRIMIDINE-2,4,6-TRIONE
5-(1-CYCLOHEXEN-1-YL)-1,5-DIMETHYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
5-(1-CYCLOHEXEN-1-YL)-1,5-DIMETHYLBARBITURIC ACID
HEXOBARBITONE
rxcui:5302
pubchem.compound:3608
chemidplus:56-29-1
chembl:CHEMBL7728
drugbank:01355

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Year of Approval	approved before 1982
Drug Class	hypnotics and sedatives

(0 More Sources)

Publications:

Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tomlin et al., 1999, Preparation of barbiturate optical isomers and their effects on GABA(A) receptors., Anesthesiology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

HEXOBARBITAL GRIK2

Interaction Score: 1.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL CHRNA4

Interaction Score: 0.78

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GRIA2

Interaction Score: 0.77

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GABRA1

Interaction Score: 0.72

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 14579514 10209232 11752352 10487207 10360871 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
HEXOBARBITAL GABRA6

Interaction Score: 0.34

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GABRA5

Interaction Score: 0.32

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GABRA3

Interaction Score: 0.31

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GABRA2

Interaction Score: 0.3

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
HEXOBARBITAL GABRA4

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

TEND: HEXOBARBITAL
- Version: 01-August-2011
Alternate Names:

HEXOBARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: HEXOBARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Hexobarbital
- Version: 2020.06.01
Alternate Names:

D00ETS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL7728
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

HEXOBARBITAL Drug Record

HEXOBARBITAL chembl:CHEMBL7728

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 14579514 10209232 11752352 10487207 10360871 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232

Sources: TdgClinicalTrial TEND

TEND: HEXOBARBITAL

Alternate Names: HEXOBARBITAL Primary Drug Name

Drug Info: Drug Class hypnotics and sedatives Year of Approval approved before 1982

Publications:

TdgClinicalTrial: HEXOBARBITAL

Alternate Names:

Drug Info: Drug Indications Hypnotics and Sedatives Drug Class small molecule FDA Approval Approved before 1982

Publications:

TTD: Hexobarbital

Alternate Names: D00ETS TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL7728

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 14579514 10209232 11752352 10487207 10360871 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

Alternate Names:

HEXOBARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D00ETS TTD Drug ID