DGIdb - HYDRALAZINE Drug Record

HYDRALAZINE chembl:CHEMBL276832 Approved

Alternate Names:

NSC-126699
HYDRALAZINE
IDRALAZINA
HYPOPHTHALIN
(2H)-PHTHALAZINONE HYDRAZONE
HIDRALAZINA
1-HYDRAZINOPHTHALAZINE
PHTHALAZIN-1-YLHYDRAZINE
(1Z)-1(2H)-PHTHALAZINONE HYDRAZONE
HYDRAZINOPHTHALAZINE
HYDRALLAZINE
1-PHTHALAZINYLHYDRAZINE
6-HYDRALAZINE
HYDRALAZIN
HYDRALAZINUM
APR968
HYDRAZONE 1(2H)-PHTHALAZINONE
APRESOLINE®
chemidplus:86-54-4
pubchem.compound:3637
chembl:CHEMBL276832
drugbank:01275
rxcui:5470

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(1 More Sources)

Publications:

Claud et al., 2001, Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat., Drug Metab. Dispos.
Vidrio et al., 2005, 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats., J. Cardiovasc. Pharmacol.
Grönvall et al., 1998, Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes., Life Sci.
Lizcano et al., 1996, Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives., Biochem. Pharmacol.
Lyles et al., 1989, The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities., J. Pharm. Pharmacol.
Vidrio et al., 2003, Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide., J. Pharmacol. Exp. Ther.
Vidrio, Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition., Auton Autacoid Pharmacol
Vidrio et al., 2007, Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor., J Neural Transm (Vienna)
Barrand et al., 1985, The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme., Biochem. J.
Grönvall et al., 2000, An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections., Neurobiology (Bp)
Barrand et al., 1984, Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane., J. Pharm. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

HYDRALAZINE AOC3

Interaction Score: 9.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name hydralazine HCl/isosorbide,BiDil

Novel drug target Established target

PMIDs:
11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources:
TdgClinicalTrial TTD
HYDRALAZINE HSPA4

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12047041

Sources:
NCI
HYDRALAZINE PKM

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE THPO

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE SMN2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE SMN1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE NPC1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE RAB9A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: HYDRALAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: HYDRALAZINE
- Version: 14-September-2017
Alternate Names:

C551 NCI drug code

Drug Info:

Publications:

Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
DTC: HYDRALAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL276832 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Hydralazine
- Version: 2020.06.01
Alternate Names:

D0K1XK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL276832
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	hydralazine HCl/isosorbide,BiDil
Novel drug target	Established target

HYDRALAZINE Drug Record

HYDRALAZINE chembl:CHEMBL276832 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name hydralazine HCl/isosorbide,BiDil Novel drug target Established target

PMIDs: 11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12047041

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: HYDRALAZINE

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: HYDRALAZINE

Alternate Names: C551 NCI drug code

Drug Info:

Publications: Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

DTC: HYDRALAZINE

Alternate Names: CHEMBL276832 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Hydralazine

Alternate Names: D0K1XK TTD Drug ID

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name hydralazine HCl/isosorbide,BiDil

Novel drug target Established target

PMIDs:
11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
12047041

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C551 NCI drug code

Publications:

Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

Alternate Names:

CHEMBL276832 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0K1XK TTD Drug ID