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HYDRALAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDRALAZINE chembl:CHEMBL276832 Approved

    Alternate Names:

    NSC-126699
    HYDRALAZINE
    IDRALAZINA
    HYPOPHTHALIN
    (2H)-PHTHALAZINONE HYDRAZONE
    HIDRALAZINA
    1-HYDRAZINOPHTHALAZINE
    PHTHALAZIN-1-YLHYDRAZINE
    (1Z)-1(2H)-PHTHALAZINONE HYDRAZONE
    HYDRAZINOPHTHALAZINE
    HYDRALLAZINE
    1-PHTHALAZINYLHYDRAZINE
    6-HYDRALAZINE
    HYDRALAZIN
    HYDRALAZINUM
    APR968
    HYDRAZONE 1(2H)-PHTHALAZINONE
    APRESOLINE®
    chemidplus:86-54-4
    pubchem.compound:3637
    chembl:CHEMBL276832
    drugbank:01275
    rxcui:5470

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antihypertensive agent
    (1 More Sources)

    Publications:

    Claud et al., 2001, Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat., Drug Metab. Dispos.
    Vidrio et al., 2005, 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats., J. Cardiovasc. Pharmacol.
    Grönvall et al., 1998, Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes., Life Sci.
    Lizcano et al., 1996, Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives., Biochem. Pharmacol.
    Lyles et al., 1989, The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities., J. Pharm. Pharmacol.
    Vidrio et al., 2003, Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide., J. Pharmacol. Exp. Ther.
    Vidrio, Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition., Auton Autacoid Pharmacol
    Vidrio et al., 2007, Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor., J Neural Transm (Vienna)
    Barrand et al., 1985, The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme., Biochem. J.
    Grönvall et al., 2000, An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections., Neurobiology (Bp)
    Barrand et al., 1984, Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane., J. Pharm. Pharmacol.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
  • HYDRALAZINE   AOC3

    Interaction Score: 13.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name hydralazine HCl/isosorbide,BiDil
    Novel drug target Established target

    PMIDs:
    11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080


    Sources:
    TdgClinicalTrial TTD

  • HYDRALAZINE   HSPA4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12047041


    Sources:
    NCI

  • HYDRALAZINE   PKM

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   THPO

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   SMN2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   SMN1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   NPC1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   RAB9A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • HYDRALAZINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • HYDRALAZINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • HYDRALAZINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • HYDRALAZINE   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRALAZINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • HYDRALAZINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: HYDRALAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antihypertensive agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: HYDRALAZINE

    • Version: 14-September-2017

    Alternate Names:
    C551 NCI drug code

    Drug Info:

    Publications:
    Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

  • DTC: HYDRALAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL276832 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Hydralazine

    • Version: 2020.06.01

    Alternate Names:
    D0K1XK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL276832

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21