DGIdb - HYDRALAZINE Drug Record

HYDRALAZINE chembl:CHEMBL276832 Approved

Alternate Names:

NSC-126699
HYDRALAZINE
IDRALAZINA
HYPOPHTHALIN
(2H)-PHTHALAZINONE HYDRAZONE
HIDRALAZINA
1-HYDRAZINOPHTHALAZINE
PHTHALAZIN-1-YLHYDRAZINE
(1Z)-1(2H)-PHTHALAZINONE HYDRAZONE
HYDRAZINOPHTHALAZINE
HYDRALLAZINE
1-PHTHALAZINYLHYDRAZINE
6-HYDRALAZINE
HYDRALAZIN
HYDRALAZINUM
APR968
HYDRAZONE 1(2H)-PHTHALAZINONE
APRESOLINE®
chemidplus:86-54-4
pubchem.compound:3637
chembl:CHEMBL276832
drugbank:01275
rxcui:5470

Drug Info:

Drug Categories	phthalazines
Drug Categories	hydrazinophthalazine derivatives and diuretics
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	arteriolar smooth muscle, agents acting on
Drug Categories	arteriolar vasodilation
Drug Categories	arteriolar vasodilator
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	direct vasodilators
Drug Categories	drugs that are mainly renally excreted
Drug Categories	hydrazinophthalazine derivatives
Drug Categories	vasodilating agents

(2 More Sources)

Publications:

Claud et al., 2001, Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat., Drug Metab. Dispos.
Vidrio et al., 2005, 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats., J. Cardiovasc. Pharmacol.
Grönvall et al., 1998, Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes., Life Sci.
Lizcano et al., 1996, Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives., Biochem. Pharmacol.
Lyles et al., 1989, The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities., J. Pharm. Pharmacol.
Vidrio et al., 2003, Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide., J. Pharmacol. Exp. Ther.
Vidrio, Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition., Auton Autacoid Pharmacol
Vidrio et al., 2007, Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor., J Neural Transm (Vienna)
Barrand et al., 1985, The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme., Biochem. J.
Grönvall et al., 2000, An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections., Neurobiology (Bp)
Barrand et al., 1984, Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane., J. Pharm. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Murad et al., 1985, A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts., Arch. Biochem. Biophys.
Chen et al., 1977, Collagen prolyl hydroxylation in WI-38 fibroblast cultures: action of hydralazine., In Vitro
Knowles et al., 2004, Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases., Circ. Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

HYDRALAZINE AOC3

Interaction Score: 7.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name hydralazine HCl/isosorbide,BiDil

Novel drug target Established target

PMIDs:
11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources:
DrugBank TdgClinicalTrial TTD
HYDRALAZINE P4HA1

Interaction Score: 3.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2994564 856725 15192023 11752352

Sources:
DrugBank
HYDRALAZINE HSPA4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12047041

Sources:
NCI
HYDRALAZINE PKM

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE HIF1A

Interaction Score: 0.05

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
15192023

Sources:
DrugBank
HYDRALAZINE THPO

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE SMN2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE SMN1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE NPC1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE RAB9A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRALAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
HYDRALAZINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB01275

Version: 5.1.7

Alternate Names:

HYDRALAZINE DrugBank Drug Name

86-54-4 CAS Number

Alphapress Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories antihypertensive agents

Publications:

Vidrio, Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition., Auton Autacoid Pharmacol

Vidrio et al., 2005, 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats., J. Cardiovasc. Pharmacol.

Vidrio et al., 2007, Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor., J Neural Transm (Vienna)

TdgClinicalTrial: HYDRALAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: HYDRALAZINE
- Version: 14-September-2017
Alternate Names:

C551 NCI drug code

Drug Info:

Publications:

Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
DTC: HYDRALAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL276832 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Hydralazine
- Version: 2020.06.01
Alternate Names:

D0K1XK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL276832
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	hydralazine HCl/isosorbide,BiDil
Novel drug target	Established target

HYDRALAZINE	DrugBank Drug Name
86-54-4	CAS Number
Alphapress	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	antihypertensive agents

HYDRALAZINE Drug Record

HYDRALAZINE chembl:CHEMBL276832 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name hydralazine HCl/isosorbide,BiDil Novel drug target Established target

PMIDs: 11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources: DrugBank TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2994564 856725 15192023 11752352

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12047041

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 15192023

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB01275

Alternate Names: HYDRALAZINE DrugBank Drug Name 86-54-4 CAS Number Alphapress Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories antihypertensive agents

TdgClinicalTrial: HYDRALAZINE

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name hydralazine HCl/isosorbide,BiDil

Novel drug target Established target

PMIDs:
11302941 16116337 9740313 8694842 2568436 12970383 15255812 17385063 4091799 11061213 6150080

Sources:
DrugBank TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2994564 856725 15192023 11752352

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12047041

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inducer (activating)

PMIDs:
15192023

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

HYDRALAZINE DrugBank Drug Name

86-54-4 CAS Number

Alphapress Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C551 NCI drug code

Publications:

Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.

Alternate Names:

CHEMBL276832 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0K1XK TTD Drug ID