DGIdb - HYDROCHLOROTHIAZIDE Drug Record

HYDROCHLOROTHIAZIDE chembl:CHEMBL435 Approved

Alternate Names:

HYDROCHLOROTHIAZIDE
ORETIC
APO-HYDRO
HYDROSALURIC
ESIDREX
HCTZ
HYDROCHLOROTHIAZIDE INTENSOL
ZIDE
SU-5879
HYDRO-D
ESIDRIX
MICROZIDE
NSC-53477
HYDRODIURIL
AQUARIUS
HYDROCHLOROTHIAZID
CIDREX
DIHYDROCHLOROTHIAZIDUM
HYDRODIURETIC
HCZ
HYPOTHIAZIDE
CAPOZIDE
DICHLOTRIDE
THLARETIC
APRESAZIDE
DICLOTRIDE
HYDROZIDE
COTAREG
3,4-DIHYDROCHLOROTHIAZIDE
RO-HYDRAZIDE
ESIDRIX (TN)
DIURIL
HYZAAR
BREMIL
URODIAZIN
LOPRESSOR HCT
FLUVIN
ZIAC
DISALUNIL
THIARETIC
JEN-DIRIL
HYDROCHLORO THIAZIDE
MAXZIDE
NEOFLUMEN
NEO-CODEMA
MEGADIURIL
DIHYDROCHLORURIT
CHLOROSULTHIADIL
TIMOLIDE
APO-HYDRO®
HYPOTHIAZID
DICHLOTIAZID
LOTENSIN HCT
HIDROCHLORTIAZID
HYDROCHLORTHIAZIDE
DIREMA
ALDORIL
SERVITHIAZID
MODURETIC
HYDROPRES
NEWTOLIDE
6-CHLORO-1,1-DIOXO-3,4-DIHYDRO-2H-1$L^{6},2,4-BENZOTHIADIAZINE-7-SULFONAMIDE
ACURETIC
DYAZIDE
CAPLARIL
HIDROTIAZIDA
ESI879
CHLORZIDE
HYDRO-DIURIL
DIHYDROCHLOROTHIAZID
ESIMIL
HIDRIL
VASERETIC
IDROTIAZIDE
AQUARILLS
NEFRIX
HYDROTHIDE
DIHYDROCHLORURITE
DIHYDROCHLOROTHIAZIDE
CHLORSULFONAMIDODIHYDROBENZOTHIADIAZINE DIOXIDE
DICHLOROSAL
IVAUGAN
INDERIDE
DRENOL
ALDACTAZIDE
VETIDREX
HYDRO-AQUIL
PRINZIDE
HIDRORONOL
DIHYDROXYCHLOROTHIAZIDUM
HYDRIL
PANURIN
CHLOROTHIAZIDE
SER-AP-ES
THIURETIC
MASCHITT
UNIPRES
chemidplus:58-93-5
drugbank:00999
chembl:CHEMBL435
pubchem.compound:3639
rxcui:5487

Drug Info:

Drug Class	Small molecule
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Class	antihypertensive agents
Drug Class	diuretics
Year of Approval	1959

(4 More Sources)

Publications:

Abuladze et al., 1998, Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport., J. Am. Soc. Nephrol.
Ran et al., 2005, [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]., Sichuan Da Xue Xue Bao Yi Xue Ban
Barry et al., 1997, Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics., Am. J. Physiol.
Kurschat et al., 2003, [Gitelman's syndrome: an important differential diagnosis of hypokalemia]., Dtsch. Med. Wochenschr.
Turner et al., 2005, WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic., Hypertension
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Monroy et al., 2000, Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction., Am. J. Physiol. Renal Physiol.
Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens
Maitland-van der Zee AH et al., 2005, Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects., Am J Hypertens
Maitland-van der Zee AH et al., 2005, A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide., Pharmacogenet Genomics
Magvanjav O et al., 2017, Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials., J Am Heart Assoc
Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
Cusi D et al., 1997, Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension., Lancet
Suonsyrjä T et al., 2009, Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study., Am J Hypertens
Manunta P et al., 2008, Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation., Hypertension
Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
Glorioso N et al., 2002, alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives., Hypertension
Glorioso N et al., 1999, The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study., Hypertension
Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc
Li Y et al., 2011, Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients., Clin Exp Hypertens
Schwartz GL et al., 2002, Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide., Kidney Int
Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.
Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J
Duarte JD et al., 2012, Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide., J Transl Med
Svensson-Färbom P et al., 2011, A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients., J Hypertens
Luo F et al., 2009, A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension., Hypertension
Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.

HYDROCHLOROTHIAZIDE WNK1

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18591455

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE NEDD4L

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21052022 19635985 18591455

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE IRF1-AS1

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE NUCB2

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE PLCE1

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ADO

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ADD1

Interaction Score: 2.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9149697 19057513 18591455 14553962 12623934 11882573 10523341

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE NELFCD

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE DIAPH3

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE UGGT2

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ILKAP

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE HMGCS2

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29523524

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE FBXL17

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ANKFN1

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE VASP

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE TXNDC11

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE YEATS4

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE DOT1L

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22440088

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE PRKAG2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE CSK

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ALDH1A2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29097388

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE SLC12A3

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name Amturnide

PMIDs:
9596079 16078592 9038817 12772080 16172412 11752352 10894798

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
HYDROCHLOROTHIAZIDE GPR83

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE CSMD1

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE SLIT1

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE SLC25A31

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE TET2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE LRRC15

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE TCF7L2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE KCNJ1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22907731

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE SERPINE1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11836266

Sources:
NCI
HYDROCHLOROTHIAZIDE PDE3A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ACE

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21269061 12371972 12623934

Sources:
PharmGKB TTD
HYDROCHLOROTHIAZIDE PRKCA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14553962 16109321 15864129

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE PTGS1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11703585

Sources:
NCI

TEND: HYDROCHLOROTHIAZIDE
- Version: 01-August-2011
Alternate Names:

HYDROCHLOROTHIAZIDE Primary Drug Name

Drug Info:

Year of Approval 1959

Drug Class diuretics

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: HYDROCHLOROTHIAZIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: HYDROCHLOROTHIAZIDE

Version: 14-September-2017

Alternate Names:

C29098 NCI drug code

Drug Info:

Publications:

Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.

Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.

PharmGKB: hydrochlorothiazide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension

Maitland-van der Zee AH et al., 2005, A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide., Pharmacogenet Genomics

Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens

GuideToPharmacology: 178101538
- Version: 29-September-2020
Alternate Names:

HYDROCHLOROTHIAZIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Hydrochlorothiazide
- Version: 2020.06.01
Alternate Names:

D0U4UQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL435
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL435
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor
Direct Interaction	yes
Trial Name	Amturnide

HYDROCHLOROTHIAZIDE Drug Record

HYDROCHLOROTHIAZIDE chembl:CHEMBL435 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18591455

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21052022 19635985 18591455

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9149697 19057513 18591455 14553962 12623934 11882573 10523341

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29523524

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22440088

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Interaction Types & Directionality:

n/a

PMIDs:
18591455

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21052022 19635985 18591455

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9149697 19057513 18591455 14553962 12623934 11882573 10523341

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29523524

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22440088

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29097388

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name Amturnide

PMIDs:
9596079 16078592 9038817 12772080 16172412 11752352 10894798

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a