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HYDROCHLOROTHIAZIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDROCHLOROTHIAZIDE chembl:CHEMBL435 Approved

    Alternate Names:

    HYDROCHLOROTHIAZIDE
    ORETIC
    APO-HYDRO
    HYDROSALURIC
    ESIDREX
    HCTZ
    HYDROCHLOROTHIAZIDE INTENSOL
    ZIDE
    SU-5879
    HYDRO-D
    ESIDRIX
    MICROZIDE
    NSC-53477
    HYDRODIURIL
    AQUARIUS
    HYDROCHLOROTHIAZID
    CIDREX
    DIHYDROCHLOROTHIAZIDUM
    HYDRODIURETIC
    HCZ
    HYPOTHIAZIDE
    CAPOZIDE
    DICHLOTRIDE
    THLARETIC
    APRESAZIDE
    DICLOTRIDE
    HYDROZIDE
    COTAREG
    3,4-DIHYDROCHLOROTHIAZIDE
    RO-HYDRAZIDE
    ESIDRIX (TN)
    DIURIL
    HYZAAR
    BREMIL
    URODIAZIN
    LOPRESSOR HCT
    FLUVIN
    ZIAC
    DISALUNIL
    THIARETIC
    JEN-DIRIL
    HYDROCHLORO THIAZIDE
    MAXZIDE
    NEOFLUMEN
    NEO-CODEMA
    MEGADIURIL
    DIHYDROCHLORURIT
    CHLOROSULTHIADIL
    TIMOLIDE
    APO-HYDRO®
    HYPOTHIAZID
    DICHLOTIAZID
    LOTENSIN HCT
    HIDROCHLORTIAZID
    HYDROCHLORTHIAZIDE
    DIREMA
    ALDORIL
    SERVITHIAZID
    MODURETIC
    HYDROPRES
    NEWTOLIDE
    6-CHLORO-1,1-DIOXO-3,4-DIHYDRO-2H-1$L^{6},2,4-BENZOTHIADIAZINE-7-SULFONAMIDE
    ACURETIC
    DYAZIDE
    CAPLARIL
    HIDROTIAZIDA
    ESI879
    CHLORZIDE
    HYDRO-DIURIL
    DIHYDROCHLOROTHIAZID
    ESIMIL
    HIDRIL
    VASERETIC
    IDROTIAZIDE
    AQUARILLS
    NEFRIX
    HYDROTHIDE
    DIHYDROCHLORURITE
    DIHYDROCHLOROTHIAZIDE
    CHLORSULFONAMIDODIHYDROBENZOTHIADIAZINE DIOXIDE
    DICHLOROSAL
    IVAUGAN
    INDERIDE
    DRENOL
    ALDACTAZIDE
    VETIDREX
    HYDRO-AQUIL
    PRINZIDE
    HIDRORONOL
    DIHYDROXYCHLOROTHIAZIDUM
    HYDRIL
    PANURIN
    CHLOROTHIAZIDE
    SER-AP-ES
    THIURETIC
    MASCHITT
    UNIPRES
    chemidplus:58-93-5
    drugbank:00999
    chembl:CHEMBL435
    pubchem.compound:3639
    rxcui:5487

    Drug Info:

    Drug Class Small molecule
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antihypertensive agent
    Drug Class antihypertensive agents
    Drug Class diuretics
    Year of Approval 1959
    (3 More Sources)

    Publications:

    Abuladze et al., 1998, Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport., J. Am. Soc. Nephrol.
    Ran et al., 2005, [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]., Sichuan Da Xue Xue Bao Yi Xue Ban
    Barry et al., 1997, Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics., Am. J. Physiol.
    Kurschat et al., 2003, [Gitelman's syndrome: an important differential diagnosis of hypokalemia]., Dtsch. Med. Wochenschr.
    Turner et al., 2005, WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic., Hypertension
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Monroy et al., 2000, Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction., Am. J. Physiol. Renal Physiol.
    Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens
    Maitland-van der Zee AH et al., 2005, Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects., Am J Hypertens
    Maitland-van der Zee AH et al., 2005, A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide., Pharmacogenet Genomics
    Magvanjav O et al., 2017, Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials., J Am Heart Assoc
    Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
    Cusi D et al., 1997, Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension., Lancet
    Suonsyrjä T et al., 2009, Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study., Am J Hypertens
    Manunta P et al., 2008, Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation., Hypertension
    Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
    Glorioso N et al., 2002, alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives., Hypertension
    Glorioso N et al., 1999, The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study., Hypertension
    Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc
    Li Y et al., 2011, Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients., Clin Exp Hypertens
    Schwartz GL et al., 2002, Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide., Kidney Int
    Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.
    Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J
    Duarte JD et al., 2012, Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide., J Transl Med
    Svensson-Färbom P et al., 2011, A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients., J Hypertens
    Luo F et al., 2009, A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension., Hypertension
    Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.
  • HYDROCHLOROTHIAZIDE   WNK1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18591455


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   NEDD4L

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21052022 19635985 18591455


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   IRF1-AS1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   NUCB2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   PLCE1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ADO

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ADD1

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9149697 19057513 18591455 14553962 12623934 11882573 10523341


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   DOT1L

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22440088


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   NELFCD

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   DIAPH3

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   UGGT2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ILKAP

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   HMGCS2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29523524


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   CSK

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   FBXL17

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ANKFN1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   VASP

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   TXNDC11

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   YEATS4

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   PRKAG2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ALDH1A2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29097388


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   SLC12A3

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Trial Name Amturnide

    PMIDs:
    9596079 16078592 9038817 12772080 16172412 11752352 10894798


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • HYDROCHLOROTHIAZIDE   GPR83

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   CSMD1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   SLIT1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   SLC25A31

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   TET2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   LRRC15

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   TCF7L2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   KCNJ1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22907731


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   SERPINE1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11836266


    Sources:
    NCI

  • HYDROCHLOROTHIAZIDE   PDE3A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ACE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21269061 12371972 12623934


    Sources:
    PharmGKB TTD

  • HYDROCHLOROTHIAZIDE   PRKCA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ADRB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14553962 16109321 15864129


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   PTGS1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11703585


    Sources:
    NCI

  • TEND: HYDROCHLOROTHIAZIDE

    • Version: 01-August-2011

    Alternate Names:
    HYDROCHLOROTHIAZIDE Primary Drug Name

    Drug Info:
    Year of Approval 1959
    Drug Class diuretics
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: HYDROCHLOROTHIAZIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antihypertensive agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: HYDROCHLOROTHIAZIDE

    • Version: 14-September-2017

    Alternate Names:
    C29098 NCI drug code

    Drug Info:

    Publications:
    Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.
    Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.

  • PharmGKB: hydrochlorothiazide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
    Maitland-van der Zee AH et al., 2005, A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide., Pharmacogenet Genomics
    Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens

  • TTD: Hydrochlorothiazide

    • Version: 2020.06.01

    Alternate Names:
    D0U4UQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL435

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL435

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21