DGIdb - HYDROCODONE Drug Record

HYDROCODONE chembl:CHEMBL1457 Approved

Alternate Names:

HYDROCODONE
IDROCODONE
HIDROCODONA
DIHYDROCODEINONE
HYDROCODON
HYDROCONE
HYDROCONUM
(-)-DIHYDROCODEINONE
4,5-ALPHA-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE
HYDROCODONE POLISTIREX
ZOHYDRO®
HYDROCODONUM
drugbank:00956
chembl:CHEMBL1457
chemidplus:125-29-1
pubchem.compound:5284569
rxcui:5489

Drug Info:

Year of Approval	approved before 1982
Drug Class	antitussive agents
Drug Class	analgesics, opioid
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic

(2 More Sources)

Publications:

Thompson et al., 2004, Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Peckham et al., 2006, Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats., J. Pharmacol. Exp. Ther.
Olson KM et al., 2019, Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids., PLoS One
Hennies et al., 1988, Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids., Arzneimittelforschung
Stoops et al., 2010, Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies., Psychopharmacology (Berl.)
Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend
Kotzer et al., 2000, The antitussive activity of delta-opioid receptor stimulation in guinea pigs., J. Pharmacol. Exp. Ther.
Boswell MV et al., 2013, The role of hydromorphone and OPRM1 in postoperative pain relief with hydrocodone., Pain Physician
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Tyndale RF et al., 1997, Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence., Pharmacogenetics
Otton SV et al., 1993, CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone., Clin Pharmacol Ther
Linares OA et al., 2015, Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing., Clin J Pain
Stauble ME et al., 2014, Hydrocodone in postoperative personalized pain management: pro-drug or drug?, Clin Chim Acta
Madadi P et al., 2010, Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions., Pediatrics
Susce MT et al., 2006, Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer., Prog Neuropsychopharmacol Biol Psychiatry
de Leon J et al., 2003, Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers., J Clin Psychopharmacol

HYDROCODONE OPRM1

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ZX002, hydrocodone bitartrate

Novel drug target Established target

Trial Name PTI-701

PMIDs:
2849950 20665209 14600248 11752352 18606504 10640321 16291875 23703421 31170174

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB
HYDROCODONE OPRD1

Interaction Score: 1.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ZX002, hydrocodone bitartrate

Novel drug target Established target

Trial Name PTI-701

PMIDs:
14600248 11752352 16291875 31170174

Sources:
TdgClinicalTrial TEND
HYDROCODONE OPRK1

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TEND GuideToPharmacology
HYDROCODONE CYP3A5

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
HYDROCODONE CYP2D6

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9352573 7693389 25621429 24269714 20837591 16631290 12920424

Sources:
PharmGKB

TEND: HYDROCODONE
- Version: 01-August-2011
Alternate Names:

HYDROCODONE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Drug Class antitussive agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: HYDROCODONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Hydrocodone
- Version: 2020.06.01
Alternate Names:

D0X5KF TTD Drug ID

Drug Info:

Publications:

Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend

PharmGKB: hydrocodone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Tyndale RF et al., 1997, Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence., Pharmacogenetics

de Leon J et al., 2003, Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers., J Clin Psychopharmacol

GuideToPharmacology: 178103660
- Version: 29-September-2020
Alternate Names:

HYDROCODONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1457
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	ZX002, hydrocodone bitartrate
Novel drug target	Established target
Trial Name	PTI-701

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	False

HYDROCODONE Drug Record

HYDROCODONE chembl:CHEMBL1457 Approved

Alternate Names:

Drug Info:

Publications:

HYDROCODONE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name ZX002, hydrocodone bitartrate Novel drug target Established target Trial Name PTI-701

PMIDs: 2849950 20665209 14600248 11752352 18606504 10640321 16291875 23703421 31170174

Sources: TdgClinicalTrial TEND GuideToPharmacology PharmGKB

HYDROCODONE OPRD1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name ZX002, hydrocodone bitartrate Novel drug target Established target Trial Name PTI-701

PMIDs: 14600248 11752352 16291875 31170174

Sources: TdgClinicalTrial TEND

HYDROCODONE OPRK1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TEND GuideToPharmacology

HYDROCODONE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

HYDROCODONE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9352573 7693389 25621429 24269714 20837591 16631290 12920424

Sources: PharmGKB

TEND: HYDROCODONE

Alternate Names: HYDROCODONE Primary Drug Name

Drug Info: Drug Class analgesics, opioid Drug Class antitussive agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: HYDROCODONE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Hydrocodone

Alternate Names: D0X5KF TTD Drug ID

Drug Info:

Publications: Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend

PharmGKB: hydrocodone

Alternate Names:

Drug Info:

GuideToPharmacology: 178103660

Alternate Names: HYDROCODONE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1457

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ZX002, hydrocodone bitartrate

Novel drug target Established target

Trial Name PTI-701

PMIDs:
2849950 20665209 14600248 11752352 18606504 10640321 16291875 23703421 31170174

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ZX002, hydrocodone bitartrate

Novel drug target Established target

Trial Name PTI-701

PMIDs:
14600248 11752352 16291875 31170174

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9352573 7693389 25621429 24269714 20837591 16631290 12920424

Sources:
PharmGKB

Alternate Names:

HYDROCODONE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Drug Class antitussive agents

Year of Approval approved before 1982

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0X5KF TTD Drug ID

Publications:

Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend

Alternate Names:

HYDROCODONE GuideToPharmacology Ligand Name