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HYDROCODONE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDROCODONE chembl:CHEMBL1457 Approved

    Alternate Names:

    HYDROCODONE
    IDROCODONE
    HIDROCODONA
    DIHYDROCODEINONE
    HYDROCODON
    HYDROCONE
    HYDROCONUM
    (-)-DIHYDROCODEINONE
    4,5-ALPHA-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE
    HYDROCODONE POLISTIREX
    ZOHYDRO®
    HYDROCODONUM
    drugbank:00956
    chembl:CHEMBL1457
    chemidplus:125-29-1
    pubchem.compound:5284569
    rxcui:5489

    Drug Info:

    Year of Approval approved before 1982
    Drug Class antitussive agents
    Drug Class analgesics, opioid
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    (1 More Sources)

    Publications:

    Thompson et al., 2004, Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Peckham et al., 2006, Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats., J. Pharmacol. Exp. Ther.
    Olson KM et al., 2019, Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids., PLoS One
    Hennies et al., 1988, Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids., Arzneimittelforschung
    Stoops et al., 2010, Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies., Psychopharmacology (Berl.)
    Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend
    Kotzer et al., 2000, The antitussive activity of delta-opioid receptor stimulation in guinea pigs., J. Pharmacol. Exp. Ther.
    Boswell MV et al., 2013, The role of hydromorphone and OPRM1 in postoperative pain relief with hydrocodone., Pain Physician
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Tyndale RF et al., 1997, Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence., Pharmacogenetics
    Otton SV et al., 1993, CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone., Clin Pharmacol Ther
    Linares OA et al., 2015, Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing., Clin J Pain
    Stauble ME et al., 2014, Hydrocodone in postoperative personalized pain management: pro-drug or drug?, Clin Chim Acta
    Madadi P et al., 2010, Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions., Pediatrics
    Susce MT et al., 2006, Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer., Prog Neuropsychopharmacol Biol Psychiatry
    de Leon J et al., 2003, Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers., J Clin Psychopharmacol
  • HYDROCODONE   OPRD1

    Interaction Score: 1.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name ZX002, hydrocodone bitartrate
    Novel drug target Established target
    Trial Name PTI-701

    PMIDs:
    14600248 11752352 16291875 31170174


    Sources:
    TdgClinicalTrial TEND

  • HYDROCODONE   OPRM1

    Interaction Score: 1.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name ZX002, hydrocodone bitartrate
    Novel drug target Established target
    Trial Name PTI-701

    PMIDs:
    2849950 20665209 14600248 11752352 18606504 10640321 16291875 23703421 31170174


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • HYDROCODONE   CYP3A5

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • HYDROCODONE   OPRK1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • HYDROCODONE   CYP2D6

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9352573 7693389 25621429 24269714 20837591 16631290 12920424


    Sources:
    PharmGKB

  • TEND: HYDROCODONE

    • Version: 01-August-2011

    Alternate Names:
    HYDROCODONE Primary Drug Name

    Drug Info:
    Drug Class analgesics, opioid
    Drug Class antitussive agents
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: HYDROCODONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • TTD: Hydrocodone

    • Version: 2020.06.01

    Alternate Names:
    D0X5KF TTD Drug ID

    Drug Info:

    Publications:
    Walsh et al., 2008, The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers., Drug Alcohol Depend

  • PharmGKB: hydrocodone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Tyndale RF et al., 1997, Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence., Pharmacogenetics
    de Leon J et al., 2003, Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers., J Clin Psychopharmacol

  • ChemblDrugs: chembl:CHEMBL1457

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21