DGIdb - HYDROMORPHONE Drug Record

HYDROMORPHONE chembl:CHEMBL398707 Approved

Alternate Names:

N02AA03
NSC-19046
DILAUDID-HP
DILAUDID
PALLADONE
IDS-NH-004
HYDROMORPHONE
4,5-EPOXY-3-HYDROXY-17-METHYLMORPHINAN-6-ONE
DIHYDROMORPHINONE
DILAUDID®
HIDROMORFONA
(-)-(5R)-4,5-EPOXY-3-HYDROXY-9ALPHA-METHYLMORPHINAN-6-ONE
PALLADONE®
DIHYDROMORFINON
HYDROMORPHONE HYDROCHLORIDE
4,5ALPHA-EPOXY-3-HYDROXY-17-METHYL-6-MORPHINANONE
6-DEOXY-7,8-DIHYDRO-6-OXOMORPHINE
HYDROMORFONA
HYDROMORPHONUM
7,8-DIHYDROMORPHINONE
DIMORPHONE
IDROMORFONE
pubchem.compound:5284570
drugbank:00327
chemidplus:466-99-9
rxcui:3423
chembl:CHEMBL398707

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Year of Approval	approved before 1982
Drug Class	analgesics, opioid

(2 More Sources)

Publications:

Hartvig et al., 1989, Brain and plasma kinetics of the opioid 11C-hydromorphone in two macaque species., Pharmacol. Toxicol.
Hennies et al., 1988, Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids., Arzneimittelforschung
Guay, 2007, Use of oral oxymorphone in the elderly., Consult Pharm
Fang et al., 1997, 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Jiang et al., 1994, 5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone and its corresponding N-cyclopropylmethyl analog, N-cyclopropylmethylnor-5 beta-methyl-14 beta-(p-nitrocinnamoylamino)- 7,8-dihydromorphinone: mu-selective irreversible opioid antagonists., J. Pharmacol. Exp. Ther.
Gharagozlou et al., 2006, Pharmacological profiles of opioid ligands at kappa opioid receptors., BMC Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract
Sarhill et al., 2001, Hydromorphone: pharmacology and clinical applications in cancer patients., Support Care Cancer
Inturrisi, Clinical pharmacology of opioids for pain., Clin J Pain
Kumar et al., 2008, Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation., Eur. J. Pharmacol.
Quigley, 2002, Hydromorphone for acute and chronic pain., Cochrane Database Syst Rev
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

HYDROMORPHONE OPRD1

Interaction Score: 1.96

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
2478994 2849950 17658959 9301669 11752352 7511163

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
HYDROMORPHONE OPRK1

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid

Direct Interaction? False

PMIDs:
16433932 17016423 17139284

Sources:
TdgClinicalTrial TEND GuideToPharmacology
HYDROMORPHONE OPRM1

Interaction Score: 0.72

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
11305075 12479250 18789923 11869661

Sources:
TdgClinicalTrial TEND GuideToPharmacology
HYDROMORPHONE CYP3A5

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
HYDROMORPHONE CYP2D6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17986163

Sources:
PharmGKB

TEND: HYDROMORPHONE
- Version: 01-August-2011
Alternate Names:

HYDROMORPHONE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: HYDROMORPHONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: hydromorphone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Hydromorphone
- Version: 2020.06.01
Alternate Names:

D04JHN TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103661
- Version: 29-September-2020
Alternate Names:

HYDROMORPHONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL398707
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	False

Novel drug target	Established target
Trial Name	NMED-1077,Exalgo, Jurnista, Dilaudid
Direct Interaction?	False

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Agonist

partial agonist (activating)
agonist (activating)

HYDROMORPHONE Drug Record

HYDROMORPHONE chembl:CHEMBL398707 Approved

Alternate Names:

Drug Info:

Publications:

HYDROMORPHONE OPRD1

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: 2478994 2849950 17658959 9301669 11752352 7511163

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

HYDROMORPHONE OPRK1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid Direct Interaction? False

PMIDs: 16433932 17016423 17139284

Sources: TdgClinicalTrial TEND GuideToPharmacology

HYDROMORPHONE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: 11305075 12479250 18789923 11869661

Sources: TdgClinicalTrial TEND GuideToPharmacology

HYDROMORPHONE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

HYDROMORPHONE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17986163

Sources: PharmGKB

TEND: HYDROMORPHONE

Alternate Names: HYDROMORPHONE Primary Drug Name

Drug Info: Drug Class analgesics, opioid Year of Approval approved before 1982

Publications:

TdgClinicalTrial: HYDROMORPHONE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: hydromorphone

Alternate Names:

Drug Info:

Publications: Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Hydromorphone

Alternate Names: D04JHN TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178103661

Alternate Names: HYDROMORPHONE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL398707

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
2478994 2849950 17658959 9301669 11752352 7511163

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid

Direct Interaction? False

PMIDs:
16433932 17016423 17139284

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
11305075 12479250 18789923 11869661

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17986163

Sources:
PharmGKB

Alternate Names:

HYDROMORPHONE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval approved before 1982

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:

Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

D04JHN TTD Drug ID

Alternate Names:

HYDROMORPHONE GuideToPharmacology Ligand Name