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HYDROMORPHONE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDROMORPHONE chembl:CHEMBL398707 Approved

    Alternate Names:

    N02AA03
    NSC-19046
    DILAUDID-HP
    DILAUDID
    PALLADONE
    IDS-NH-004
    HYDROMORPHONE
    4,5-EPOXY-3-HYDROXY-17-METHYLMORPHINAN-6-ONE
    DIHYDROMORPHINONE
    DILAUDID®
    HIDROMORFONA
    (-)-(5R)-4,5-EPOXY-3-HYDROXY-9ALPHA-METHYLMORPHINAN-6-ONE
    PALLADONE®
    DIHYDROMORFINON
    HYDROMORPHONE HYDROCHLORIDE
    4,5ALPHA-EPOXY-3-HYDROXY-17-METHYL-6-MORPHINANONE
    6-DEOXY-7,8-DIHYDRO-6-OXOMORPHINE
    HYDROMORFONA
    HYDROMORPHONUM
    7,8-DIHYDROMORPHINONE
    DIMORPHONE
    IDROMORFONE
    pubchem.compound:5284570
    drugbank:00327
    chemidplus:466-99-9
    rxcui:3423
    chembl:CHEMBL398707

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Year of Approval approved before 1982
    Drug Class analgesics, opioid
    (1 More Sources)

    Publications:

    Hartvig et al., 1989, Brain and plasma kinetics of the opioid 11C-hydromorphone in two macaque species., Pharmacol. Toxicol.
    Hennies et al., 1988, Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids., Arzneimittelforschung
    Guay, 2007, Use of oral oxymorphone in the elderly., Consult Pharm
    Fang et al., 1997, 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands., J. Med. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jiang et al., 1994, 5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone and its corresponding N-cyclopropylmethyl analog, N-cyclopropylmethylnor-5 beta-methyl-14 beta-(p-nitrocinnamoylamino)- 7,8-dihydromorphinone: mu-selective irreversible opioid antagonists., J. Pharmacol. Exp. Ther.
    Gharagozlou et al., 2006, Pharmacological profiles of opioid ligands at kappa opioid receptors., BMC Pharmacol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract
    Sarhill et al., 2001, Hydromorphone: pharmacology and clinical applications in cancer patients., Support Care Cancer
    Inturrisi, Clinical pharmacology of opioids for pain., Clin J Pain
    Kumar et al., 2008, Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation., Eur. J. Pharmacol.
    Quigley, 2002, Hydromorphone for acute and chronic pain., Cochrane Database Syst Rev
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
  • HYDROMORPHONE   OPRD1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid
    Novel drug target Established target

    PMIDs:
    2478994 2849950 17658959 9301669 11752352 7511163


    Sources:
    TdgClinicalTrial TEND TTD

  • HYDROMORPHONE   OPRK1

    Interaction Score: 0.91

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid

    PMIDs:
    16433932 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • HYDROMORPHONE   OPRM1

    Interaction Score: 0.71

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name NMED-1077,Exalgo, Jurnista, Dilaudid
    Novel drug target Established target

    PMIDs:
    11305075 12479250 18789923 11869661


    Sources:
    TdgClinicalTrial TEND

  • HYDROMORPHONE   CYP3A5

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • HYDROMORPHONE   CYP2D6

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17986163


    Sources:
    PharmGKB

  • TEND: HYDROMORPHONE

    • Version: 01-August-2011

    Alternate Names:
    HYDROMORPHONE Primary Drug Name

    Drug Info:
    Drug Class analgesics, opioid
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: HYDROMORPHONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: hydromorphone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • TTD: Hydromorphone

    • Version: 2020.06.01

    Alternate Names:
    D04JHN TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL398707

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21