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IFOSFAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • IFOSFAMIDE chembl:CHEMBL1024 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    MITOXANA
    Z-4942
    IFSOFAMIDE
    IFEX
    NSC-109724
    IFOSFAMIDE
    MJF-9325
    ISOSFAMIDE
    IPHOSPHAMIDE
    ISOFOSFAMIDE
    IFOSFAMIDA
    ISOPHOSPHAMIDE
    3-(2-CHLOROETHYL)-2-((2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
    IFEX®
    IFOSFAMIDUM
    HOLOXAN®
    chembl:CHEMBL1024
    pubchem.compound:3690
    chemidplus:3778-73-2
    rxcui:5657
    drugbank:01181

    Drug Info:

    Drug Class antineoplastic agents
    Year of Approval 1988
    FDA Approval 1988
    Drug Class small molecule
    Drug Indications Antineoplastic Agents
    (3 More Sources)

    Publications:

    Ohnstad et al., 2013, Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma., Cancer
    Heits et al., 1997, Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia., Eur. J. Haematol.
    Preuss et al., 1996, Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs., Int. J. Cancer
    Zielińska et al., 2005, Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children., J. Pediatr. Hematol. Oncol.
    Komatsu T et al., 2000, Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4., Drug Metab Dispos
    Torchin CD et al., 1996, Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes., Drug Metab Dispos
    Di YM et al., 2009, Structure, function, regulation and polymorphism of human cytochrome P450 2A6., Curr Drug Metab
    Restrepo JG et al., 2009, Polymorphic drug metabolism in anaesthesia., Curr Drug Metab
    Kimber-Trojnar Z et al., 2003, Perspectives of losigamone in epilepsy treatment., Pol J Pharmacol
    Pearce RE et al., 2002, Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites., Drug Metab Dispos
    Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
    Gehrmann et al., 2002, Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels., Biol. Chem.
    Harmsen et al., 2009, Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor., Cancer Chemother. Pharmacol.
  • IFOSFAMIDE   CYP2A6

    Interaction Score: 2.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11038165 8886611 19702528 19442086 14704462 12386121


    Sources:
    PharmGKB

  • IFOSFAMIDE   MGMT

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8621235


    Sources:
    NCI

  • IFOSFAMIDE   IL6

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9260581


    Sources:
    NCI

  • IFOSFAMIDE   DNMT1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • IFOSFAMIDE   HSPA4

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12530536


    Sources:
    NCI

  • IFOSFAMIDE   CYP2B6

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11470993 17638512


    Sources:
    PharmGKB

  • IFOSFAMIDE   GSTP1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16282887


    Sources:
    NCI

  • IFOSFAMIDE   NR1I2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18839173


    Sources:
    PharmGKB

  • IFOSFAMIDE   TP53

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Doxorubicin + Ifosfamide
    Indication/Tumor Type sarcoma
    Response Type sensitive

    PMIDs:
    23165797


    Sources:
    JAX-CKB

  • TEND: IFOSFAMIDE

    • Version: 01-August-2011

    Alternate Names:
    IFOSFAMIDE Primary Drug Name

    Drug Info:
    Year of Approval 1988
    Drug Class antineoplastic agents

    Publications:

  • TdgClinicalTrial: IFOSFAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antineoplastic Agents
    Drug Class small molecule
    FDA Approval 1988

    Publications:

  • NCI: IFOSFAMIDE

    • Version: 14-September-2017

    Alternate Names:
    C564 NCI drug code

    Drug Info:

    Publications:
    Preuss et al., 1996, Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs., Int. J. Cancer
    Zielińska et al., 2005, Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children., J. Pediatr. Hematol. Oncol.
    Gehrmann et al., 2002, Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels., Biol. Chem.

  • PharmGKB: ifosfamide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Pearce RE et al., 2002, Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites., Drug Metab Dispos
    Di YM et al., 2009, Structure, function, regulation and polymorphism of human cytochrome P450 2A6., Curr Drug Metab
    Restrepo JG et al., 2009, Polymorphic drug metabolism in anaesthesia., Curr Drug Metab

  • JAX-CKB: Ifosfamide

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Ohnstad et al., 2013, Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma., Cancer

  • TTD: Ifosfamide

    • Version: 2020.06.01

    Alternate Names:
    D02TLO TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1024

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21