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ILOPERIDONE Drug Record

  • Summary
  • Interactions
  • Claims
  • ILOPERIDONE chembl:CHEMBL14376 Approved

    Alternate Names:

    FANAPT
    ILOPERIDONE
    HP-873
    1-[4-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1- PIPERIDINYL]PROPOXY]-3-METHOXYPHENYL]ETHANONE
    ILO522
    4'-{3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY}-3'-METHOXYACETOPHENONE
    pubchem.compound:71360
    chemidplus:133454-47-4
    chembl:CHEMBL14376
    drugbank:04946
    rxcui:73178

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 2009
    FDA Approval approved
    Drug Class Small molecule
    Drug Indications antipsychotic agent,atypical
    (3 More Sources)

    Publications:

    Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
    Kongsamut et al., 1996, Iloperidone binding to human and rat dopamine and 5-HT receptors., Eur. J. Pharmacol.
    Hesselink, 2002, Iloperidone (Novartis)., IDrugs
    George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
    Volpi S et al., 2009, Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia., Mol Psychiatry
    Potkin SG et al., 2013, A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone., J Clin Psychopharmacol
  • ILOPERIDONE   CELF4

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18521091


    Sources:
    PharmGKB

  • ILOPERIDONE   NUBPL

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18521091


    Sources:
    PharmGKB

  • ILOPERIDONE   CERKL

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18521091


    Sources:
    PharmGKB

  • ILOPERIDONE   NRG3

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18521091


    Sources:
    PharmGKB

  • ILOPERIDONE   HTR6

    Interaction Score: 0.75

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   HTR7

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   HTR2A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Novel drug target Established target

    PMIDs:
    8997630 12861482


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ILOPERIDONE   DRD2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine D2 receptor antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    8997630 12861482


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ILOPERIDONE   HTR1A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   DRD3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   ADRA2C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   HRH1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   DRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23277250


    Sources:
    PharmGKB FDA

  • TEND: ILOPERIDONE

    • Version: 01-August-2011

    Alternate Names:
    ILOPERIDONE Primary Drug Name

    Drug Info:
    Year of Approval 2009
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: ILOPERIDONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antipsychotic agent,atypical
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • PharmGKB: iloperidone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Volpi S et al., 2009, Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia., Mol Psychiatry
    Potkin SG et al., 2013, A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone., J Clin Psychopharmacol

  • TTD: Iloperidone

    • Version: 2020.06.01

    Alternate Names:
    D0M8VE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL14376

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL14376

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Iloperidone

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21