DGIdb - ILOPERIDONE Drug Record

ILOPERIDONE chembl:CHEMBL14376 Approved

Alternate Names:

FANAPT
ILOPERIDONE
HP-873
1-[4-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1- PIPERIDINYL]PROPOXY]-3-METHOXYPHENYL]ETHANONE
ILO522
4'-{3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY}-3'-METHOXYACETOPHENONE
pubchem.compound:71360
chemidplus:133454-47-4
chembl:CHEMBL14376
drugbank:04946
rxcui:73178

Drug Info:

Drug Class	antipsychotic agents
Year of Approval	2009
FDA Approval	approved
Drug Class	Small molecule
Drug Indications	antipsychotic agent,atypical

(3 More Sources)

Publications:

Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
Kongsamut et al., 1996, Iloperidone binding to human and rat dopamine and 5-HT receptors., Eur. J. Pharmacol.
Hesselink, 2002, Iloperidone (Novartis)., IDrugs
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Volpi S et al., 2009, Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia., Mol Psychiatry
Potkin SG et al., 2013, A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone., J Clin Psychopharmacol

ILOPERIDONE CELF4

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18521091

Sources:
PharmGKB
ILOPERIDONE NUBPL

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18521091

Sources:
PharmGKB
ILOPERIDONE CERKL

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18521091

Sources:
PharmGKB
ILOPERIDONE NRG3

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18521091

Sources:
PharmGKB
ILOPERIDONE HTR6

Interaction Score: 0.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial
ILOPERIDONE HTR7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial
ILOPERIDONE HTR2A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Novel drug target Established target

PMIDs:
8997630 12861482

Sources:
TdgClinicalTrial ChemblInteractions TTD
ILOPERIDONE DRD2

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine D2 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
8997630 12861482

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ILOPERIDONE HTR1A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial
ILOPERIDONE DRD3

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial
ILOPERIDONE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial
ILOPERIDONE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ILOPERIDONE HRH1

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial
ILOPERIDONE DRD1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial
ILOPERIDONE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23277250

Sources:
PharmGKB FDA

TEND: ILOPERIDONE
- Version: 01-August-2011
Alternate Names:

ILOPERIDONE Primary Drug Name

Drug Info:

Year of Approval 2009

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: ILOPERIDONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antipsychotic agent,atypical

Drug Class Small molecule

FDA Approval approved

Publications:

PharmGKB: iloperidone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Volpi S et al., 2009, Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia., Mol Psychiatry

Potkin SG et al., 2013, A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone., J Clin Psychopharmacol

TTD: Iloperidone
- Version: 2020.06.01
Alternate Names:

D0M8VE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL14376
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL14376
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Iloperidone
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist
Novel drug target	Established target

Mechanism of Interaction	Dopamine D2 receptor antagonist
Direct Interaction	yes
Novel drug target	Established target

ILOPERIDONE Drug Record

ILOPERIDONE chembl:CHEMBL14376 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18521091

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18521091

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18521091

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18521091

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist Novel drug target Established target

PMIDs: 8997630 12861482

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine D2 receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: 8997630 12861482

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: 23545936

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: 23545936

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23277250

Sources: PharmGKB FDA

TEND: ILOPERIDONE

Alternate Names: ILOPERIDONE Primary Drug Name

Drug Info: Year of Approval 2009 Drug Class antipsychotic agents

Publications:

TdgClinicalTrial: ILOPERIDONE

Alternate Names:

Drug Info: Drug Indications antipsychotic agent,atypical Drug Class Small molecule FDA Approval approved

Publications:

PharmGKB: iloperidone

Alternate Names:

Drug Info:

TTD: Iloperidone

Alternate Names: D0M8VE TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18521091

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18521091

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18521091

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18521091

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Novel drug target Established target

PMIDs:
8997630 12861482

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine D2 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
8997630 12861482

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23277250

Sources:
PharmGKB FDA

Alternate Names:

ILOPERIDONE Primary Drug Name

Drug Info:

Year of Approval 2009

Drug Class antipsychotic agents

Drug Info:

Drug Indications antipsychotic agent,atypical

Drug Class Small molecule

FDA Approval approved

Alternate Names:

D0M8VE TTD Drug ID