DGIdb - IMIPRAMINE Drug Record

IMIPRAMINE chembl:CHEMBL11 Approved

Alternate Names:

PRAMINE
IMIPRAMINE
TOFRANIL
NSC-169866
ORG-2463
TOFRANIL-PM
JANIMINE
PRESAMINE
IMIPRAMINUM
IMIPRAMIN
ANTIDEPRIN
IRMIN
MELIPRAMINE
N-(GAMMA-DIMETHYLAMINOPROPYL)IMINODIBENZYL
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE
5-[3-(DIMETHYLAMINO)PROPYL]-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE
N-(Γ-DIMETHYLAMINOPROPYL)IMINODIBENZYL
IMIZINE
chembl:CHEMBL11
drugbank:00458
rxcui:5691
pubchem.compound:3696
chemidplus:50-49-7

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Year of Approval	approved before 1982
Drug Class	antidepressive agents, tricyclic

(5 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Kantor et al., 2001, Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells., J. Pharmacol. Exp. Ther.
Tatsumi et al., 1999, Pharmacological profile of neuroleptics at human monoamine transporters., Eur. J. Pharmacol.
Anton et al., 2004, Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells., J Gene Med
Dziedzicka-Wasylewska et al., 2006, Effect of antidepressant drugs in mice lacking the norepinephrine transporter., Neuropsychopharmacology
Mitchell et al., 2006, The effects of norepinephrine transporter inactivation on locomotor activity in mice., Biol. Psychiatry
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
García-Ferreiro et al., 2004, Mechanism of block of hEag1 K+ channels by imipramine and astemizole., J. Gen. Physiol.
Toll et al., 1998, Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications., NIDA Res. Monogr.
Leboyer et al., 1999, Decreased serotonin transporter binding in unaffected relatives of manic depressive patients., Biol. Psychiatry
Schloss et al., 1995, Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1., Biochemistry
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Barkan et al., 2004, Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes., Eur Neuropsychopharmacol
Scholze et al., 2000, Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter., J. Pharmacol. Exp. Ther.
Quintin et al., 2001, Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder., Biol. Psychiatry
Goulet et al., 2001, Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?, Synapse
Yagasaki et al., 2006, Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release., J. Biol. Chem.
Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.

IMIPRAMINE MC2R

Interaction Score: 1.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11900811

Sources:
NCI
IMIPRAMINE SLC6A4

Interaction Score: 0.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10624553 7548008 9537821 15056483 10869387 11513817 11746710

Sources:
TdgClinicalTrial TEND GuideToPharmacology
IMIPRAMINE KCNH1

Interaction Score: 0.82

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
15365094

Sources:
GuideToPharmacology
IMIPRAMINE SLC6A2

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11356924 10193665 14716684 16554743 16893531

Sources:
TdgClinicalTrial TEND GuideToPharmacology
IMIPRAMINE BDNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16522641

Sources:
NCI
IMIPRAMINE CHRM2

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7855217

Sources:
GuideToPharmacology
IMIPRAMINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
9686407

Sources:
DTC
IMIPRAMINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
IMIPRAMINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC FDA
IMIPRAMINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
IMIPRAMINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 9187528

Sources:
DTC PharmGKB
IMIPRAMINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
IMIPRAMINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: IMIPRAMINE
- Version: 01-August-2011
Alternate Names:

IMIPRAMINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: IMIPRAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

NCI: IMIPRAMINE

Version: 14-September-2017

Alternate Names:

C29116 NCI drug code

Drug Info:

Publications:

Yagasaki et al., 2006, Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release., J. Biol. Chem.

Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.

DTC: IMIPRAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL11 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: imipramine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Imipramine
- Version: 2020.06.01
Alternate Names:

D06ZUK TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650384
- Version: 29-September-2020
Alternate Names:

IMIPRAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL11
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Imipramine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Displacement of [<sup>3</sup>H]citalopram from hSERT.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

IMIPRAMINE Drug Record

IMIPRAMINE chembl:CHEMBL11 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11900811

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 10624553 7548008 9537821 15056483 10869387 11513817 11746710

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: 15365094

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 11356924 10193665 14716684 16554743 16893531

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16522641

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 7855217

Sources: GuideToPharmacology

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 9686407

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300 9187528

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: IMIPRAMINE

Alternate Names: IMIPRAMINE Primary Drug Name

Drug Info: Drug Class antidepressive agents, tricyclic Year of Approval approved before 1982

Publications:

TdgClinicalTrial: IMIPRAMINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Tricyclic Drug Class small molecule FDA Approval Approved before 1982

Publications:

NCI: IMIPRAMINE

Alternate Names: C29116 NCI drug code

Drug Info:

DTC: IMIPRAMINE

Alternate Names: CHEMBL11 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: imipramine

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Imipramine

Alternate Names: D06ZUK TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11900811

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10624553 7548008 9537821 15056483 10869387 11513817 11746710

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
15365094

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11356924 10193665 14716684 16554743 16893531

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
16522641

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7855217

Sources:
GuideToPharmacology

Interaction Types & Directionality:

binder

PMIDs:
9686407

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300 9187528

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

IMIPRAMINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval approved before 1982

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

C29116 NCI drug code

Alternate Names:

CHEMBL11 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D06ZUK TTD Drug ID

Alternate Names:

IMIPRAMINE GuideToPharmacology Ligand Name