DGIdb - IMIPRAMINE Drug Record

IMIPRAMINE chembl:CHEMBL11 Approved

Alternate Names:

PRAMINE
IMIPRAMINE
TOFRANIL
NSC-169866
ORG-2463
TOFRANIL-PM
JANIMINE
PRESAMINE
IMIPRAMINUM
IMIPRAMIN
ANTIDEPRIN
IRMIN
MELIPRAMINE
N-(GAMMA-DIMETHYLAMINOPROPYL)IMINODIBENZYL
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE
5-[3-(DIMETHYLAMINO)PROPYL]-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE
N-(Γ-DIMETHYLAMINOPROPYL)IMINODIBENZYL
IMIZINE
chembl:CHEMBL11
drugbank:00458
rxcui:5691
pubchem.compound:3696
chemidplus:50-49-7

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Year of Approval	approved before 1982
Drug Class	antidepressive agents, tricyclic
Drug Categories	adrenergic alpha-1 receptor antagonists
Drug Categories	adrenergic alpha-antagonists
Drug Categories	adrenergic antagonists
Drug Categories	agents producing tachycardia
Drug Categories	agents that produce hypertension
Drug Categories	agents that reduce seizure threshold
Drug Categories	anticholinergic agents
Drug Categories	combined inhibitors of serotonin/norepinephrine reuptake
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c18 substrates
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (weak)
Drug Categories	cytochrome p-450 cyp2e1 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inhibitors
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a7 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	histamine antagonists
Drug Categories	histamine h1 antagonists
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	muscarinic antagonists
Drug Categories	neurotoxic agents
Drug Categories	oct2 inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	qtc prolonging agents
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin 5-ht2 receptor antagonists
Drug Categories	serotonin agents
Drug Categories	serotonin receptor antagonists
Drug Categories	tertiary amine tricyclic antidepressants
Drug Categories	tricyclics and other norepinephrine-reuptake inhibitors

(6 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Teschemacher et al., 1999, Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline., Br. J. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Roth, 1994, Multiple serotonin receptors: clinical and experimental aspects., Ann Clin Psychiatry
Lucchelli et al., 2000, The interaction of antidepressant drugs with enteric 5-HT7 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
Mitchell et al., 2006, The effects of norepinephrine transporter inactivation on locomotor activity in mice., Biol. Psychiatry
Tatsumi et al., 1999, Pharmacological profile of neuroleptics at human monoamine transporters., Eur. J. Pharmacol.
Anton et al., 2004, Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells., J Gene Med
Kantor et al., 2001, Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells., J. Pharmacol. Exp. Ther.
Dziedzicka-Wasylewska et al., 2006, Effect of antidepressant drugs in mice lacking the norepinephrine transporter., Neuropsychopharmacology
Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
García-Ferreiro et al., 2004, Mechanism of block of hEag1 K+ channels by imipramine and astemizole., J. Gen. Physiol.
Grimaldi et al., 1998, Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in the rat brain during ontogenetic development., Naunyn Schmiedebergs Arch. Pharmacol.
Toll et al., 1998, Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications., NIDA Res. Monogr.
Casis et al., 1998, Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel., J. Cardiovasc. Pharmacol.
Pälvimäki et al., 1996, Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor., Psychopharmacology (Berl.)
Barkan et al., 2004, Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes., Eur Neuropsychopharmacol
Leboyer et al., 1999, Decreased serotonin transporter binding in unaffected relatives of manic depressive patients., Biol. Psychiatry
Goulet et al., 2001, Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?, Synapse
Scholze et al., 2000, Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter., J. Pharmacol. Exp. Ther.
Schloss et al., 1995, Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1., Biochemistry
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Quintin et al., 2001, Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder., Biol. Psychiatry
Zanoveli et al., 2005, Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety., Behav Pharmacol
Yagasaki et al., 2006, Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release., J. Biol. Chem.
Peddi et al., 2004, Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA)., Bioorg. Med. Chem. Lett.
Melikian et al., 1999, Membrane trafficking regulates the activity of the human dopamine transporter., J. Neurosci.
Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.
Haddjeri et al., 1998, Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors., J. Neurosci.
Hervé et al., 1996, Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein., Pharmacogenetics

IMIPRAMINE ORM2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8946472

Sources:
DrugBank
IMIPRAMINE KCND2

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9781919

Sources:
DrugBank
IMIPRAMINE KCNH1

Interaction Score: 0.44

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
15365094

Sources:
DrugBank GuideToPharmacology
IMIPRAMINE MC2R

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11900811

Sources:
NCI
IMIPRAMINE KCND3

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9781919

Sources:
DrugBank
IMIPRAMINE SLC6A4

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
15056483 10624553 11746710 10869387 7548008 9537821 11513817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
IMIPRAMINE SLC6A2

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16893531 10193665 14716684 11356924 16554743

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
IMIPRAMINE HTR6

Interaction Score: 0.1

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
7804391 9606024

Sources:
DrugBank
IMIPRAMINE HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7804391 10997731

Sources:
DrugBank
IMIPRAMINE BDNF

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16522641

Sources:
NCI
IMIPRAMINE ADRA1D

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20363235

Sources:
DrugBank
IMIPRAMINE CHRM2

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7855217

Sources:
DrugBank GuideToPharmacology
IMIPRAMINE SLC6A3

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10479674

Sources:
DrugBank
IMIPRAMINE CHRM4

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
IMIPRAMINE CHRM5

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
IMIPRAMINE HTR2C

Interaction Score: 0.04

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

PMIDs:
7804391 8876023

Sources:
DrugBank
IMIPRAMINE ADRA1B

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20363235

Sources:
DrugBank
IMIPRAMINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 20363235

Sources:
DrugBank
IMIPRAMINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
9686407

Sources:
DTC DrugBank
IMIPRAMINE HTR2A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 16170231

Sources:
DrugBank
IMIPRAMINE CHRM3

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
IMIPRAMINE HTR1A

Interaction Score: 0.02

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
9822768

Sources:
DrugBank
IMIPRAMINE CHRM1

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
IMIPRAMINE HRH1

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
IMIPRAMINE DRD2

Interaction Score: 0.02

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
15081025

Sources:
DrugBank
IMIPRAMINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10510461

Sources:
DrugBank
IMIPRAMINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
IMIPRAMINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC FDA
IMIPRAMINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
IMIPRAMINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 9187528

Sources:
DTC PharmGKB
IMIPRAMINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
IMIPRAMINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00458

Version: 5.1.7

Alternate Names:

IMIPRAMINE DrugBank Drug Name

50-49-7 CAS Number

Antidep Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic agents

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)

Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology

Barkan et al., 2004, Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes., Eur Neuropsychopharmacol

TEND: IMIPRAMINE
- Version: 01-August-2011
Alternate Names:

IMIPRAMINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: IMIPRAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

NCI: IMIPRAMINE

Version: 14-September-2017

Alternate Names:

C29116 NCI drug code

Drug Info:

Publications:

Yagasaki et al., 2006, Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release., J. Biol. Chem.

Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.

DTC: IMIPRAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL11 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: imipramine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Imipramine
- Version: 2020.06.01
Alternate Names:

D06ZUK TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650384
- Version: 29-September-2020
Alternate Names:

IMIPRAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL11
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Imipramine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Displacement of [<sup>3</sup>H]citalopram from hSERT.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

IMIPRAMINE	DrugBank Drug Name
50-49-7	CAS Number
Antidep	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	adrenergic agents

binder
antagonist (inhibitory)

IMIPRAMINE Drug Record

IMIPRAMINE chembl:CHEMBL11 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8946472

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9781919

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: 15365094

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11900811

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9781919

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 15056483 10624553 11746710 10869387 7548008 9537821 11513817

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 16893531 10193665 14716684 11356924 16554743

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 7804391 9606024

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7804391 10997731

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16522641

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 20363235

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 7855217

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10479674

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7855217

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7855217

Sources: DrugBank

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info:

PMIDs: 7804391 8876023

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 20363235

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7855217 20363235

Sources: DrugBank

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 9686407

Interaction Types & Directionality:

n/a

PMIDs:
8946472

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9781919

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
15365094

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11900811

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9781919

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of [<sup>3</sup>H]citalopram from hSERT.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
15056483 10624553 11746710 10869387 7548008 9537821 11513817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16893531 10193665 14716684 11356924 16554743

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

binder

PMIDs:
7804391 9606024

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7804391 10997731

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16522641

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
20363235

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7855217

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10479674

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217

Sources:
DrugBank

Interaction Types & Directionality:

binder

antagonist (inhibitory)

PMIDs:
7804391 8876023

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
20363235

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217 20363235

Sources:
DrugBank

Interaction Types & Directionality:

binder

PMIDs:
9686407

Sources:
DTC DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217 16170231

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
9822768

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217

Sources:
DrugBank

Interaction Types & Directionality:

binder

PMIDs:
15081025

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)