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INDOLE-3-CARBINOL Drug Record

  • Summary
  • Interactions
  • Claims
  • INDOLE-3-CARBINOL chembl:CHEMBL155625

    Alternate Names:

    INDOLE-3-CARBINOL
    NSC-525801

    Drug Info:

    (0 More Sources)

    Publications:

    Garcia et al., 2005, Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex., J. Biol. Chem.
    Chatterji et al., 2004, Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells., Carcinogenesis
    Lee et al., 2005, Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner., Biochem. Biophys. Res. Commun.
    Howells et al., 2005, Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells., Clin. Cancer Res.
  • INDOLE-3-CARBINOL   IFNGR1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14988219


    Sources:
    NCI

  • INDOLE-3-CARBINOL   GDF15

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15670751


    Sources:
    NCI

  • INDOLE-3-CARBINOL   PIK3CB

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16322316


    Sources:
    NCI

  • INDOLE-3-CARBINOL   CDK2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15611077


    Sources:
    NCI

  • INDOLE-3-CARBINOL   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • INDOLE-3-CARBINOL   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: INDOLE-3-CARBINOL

    • Version: 14-September-2017

    Alternate Names:
    C1135 NCI drug code

    Drug Info:

    Publications:
    Chatterji et al., 2004, Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells., Carcinogenesis
    Howells et al., 2005, Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells., Clin. Cancer Res.
    Garcia et al., 2005, Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex., J. Biol. Chem.

  • DTC: INDOLE-3-CARBINOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL155625 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL155625

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21