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IONOMYCIN Drug Record

  • Summary
  • Interactions
  • Claims
  • IONOMYCIN chembl:CHEMBL501617

    Alternate Names:

    IONOMYCIN

    Drug Info:

    (0 More Sources)

    Publications:

    Ziegler et al., 1990, Ca2+ potentiates cAMP-dependent expression of urokinase-type plasminogen activator gene through a calmodulin- and protein kinase C-independent mechanism., J. Biol. Chem.
    Fan et al., 2005, G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II., J. Biol. Chem.
    Condon et al., 2002, Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase., Endocrinology
    Ojuka, 2004, Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle., Proc Nutr Soc
    Conus et al., 1998, Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k., J. Biol. Chem.
    Waldron et al., 1997, Store-operated Ca2+ entry and coupling to Ca2+ pool depletion in thapsigargin-resistant cells., J. Biol. Chem.
    Amino et al., 2002, Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca(2+)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase., J. Biochem.
    Okamoto et al., 1994, The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization., J. Biol. Chem.
    Matuszyk et al., 1998, Thymic lymphomas are resistant to Nur77-mediated apoptosis., Biochem. Biophys. Res. Commun.
    Kochel et al., 2005, Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004., Biochem. Biophys. Res. Commun.
    Teutsch et al., 1995, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin., Int. Immunol.
  • IONOMYCIN   CD5

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7540861


    Sources:
    NCI

  • IONOMYCIN   NR4A1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9705872 16051191


    Sources:
    NCI

  • IONOMYCIN   CAMK2B

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15845548 12193581


    Sources:
    NCI

  • IONOMYCIN   TGM2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9045668


    Sources:
    NCI

  • IONOMYCIN   PLAU

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1701176


    Sources:
    NCI

  • IONOMYCIN   CXCL8

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7510691


    Sources:
    NCI

  • IONOMYCIN   BDNF

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12038986


    Sources:
    NCI

  • IONOMYCIN   PIK3CG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9468542


    Sources:
    NCI

  • IONOMYCIN   NFE2L2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15294043


    Sources:
    NCI

  • NCI: IONOMYCIN

    • Version: 14-September-2017

    Alternate Names:
    C596 NCI drug code

    Drug Info:

    Publications:
    Teutsch et al., 1995, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin., Int. Immunol.
    Okamoto et al., 1994, The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization., J. Biol. Chem.
    Kochel et al., 2005, Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004., Biochem. Biophys. Res. Commun.

  • ChemblDrugs: chembl:CHEMBL501617

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21