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IROFULVEN Drug Record

  • Summary
  • Interactions
  • Claims
  • IROFULVEN chembl:CHEMBL118218 Antineoplastic

    Alternate Names:

    IROFULVEN
    MGI-114
    NSC-683863
    6-HYDROXYMETHYLACYLFULVENE
    HMAF
    chembl:CHEMBL118218
    drugbank:05786
    pubchem.compound:148189
    chemidplus:158440-71-2

    Drug Info:

    (0 More Sources)

    Publications:

    Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
    Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.
    Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.
  • IROFULVEN   BRCA1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17229870


    Sources:
    NCI

  • IROFULVEN   MAPK1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12014623


    Sources:
    NCI

  • IROFULVEN   NFE2L2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9195958


    Sources:
    NCI

  • NCI: IROFULVEN

    • Version: 14-September-2017

    Alternate Names:
    C1717 NCI drug code

    Drug Info:

    Publications:
    Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.

  • NCI: 6-HYDROXYMETHYLACYLFULVENE

    • Version: 14-September-2017

    Alternate Names:
    C1717 NCI drug code

    Drug Info:

    Publications:
    Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.

  • NCI: HMAF

    • Version: 14-September-2017

    Alternate Names:
    C1717 NCI drug code

    Drug Info:

    Publications:
    Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.

  • ChemblDrugs: chembl:CHEMBL118218

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21