DGIdb - IROFULVEN Drug Record

IROFULVEN chembl:CHEMBL118218 Antineoplastic

Alternate Names:

IROFULVEN
MGI-114
NSC-683863
6-HYDROXYMETHYLACYLFULVENE
HMAF
chembl:CHEMBL118218
drugbank:05786
pubchem.compound:148189
chemidplus:158440-71-2

Drug Info:

(0 More Sources)

Publications:

Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.
Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.

IROFULVEN BRCA1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17229870

Sources:
NCI
IROFULVEN MAPK1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12014623

Sources:
NCI
IROFULVEN NFE2L2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9195958

Sources:
NCI

NCI: IROFULVEN
- Version: 14-September-2017
Alternate Names:

C1717 NCI drug code

Drug Info:

Publications:

Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.
NCI: 6-HYDROXYMETHYLACYLFULVENE
- Version: 14-September-2017
Alternate Names:

C1717 NCI drug code

Drug Info:

Publications:

Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
NCI: HMAF
- Version: 14-September-2017
Alternate Names:

C1717 NCI drug code

Drug Info:

Publications:

Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.
ChemblDrugs: chembl:CHEMBL118218
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

IROFULVEN Drug Record

IROFULVEN chembl:CHEMBL118218 Antineoplastic

Alternate Names:

Drug Info:

Publications:

IROFULVEN BRCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17229870

Sources: NCI

IROFULVEN MAPK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12014623

Sources: NCI

IROFULVEN NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9195958

Sources: NCI

NCI: IROFULVEN

Alternate Names: C1717 NCI drug code

Drug Info:

Publications: Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.

NCI: 6-HYDROXYMETHYLACYLFULVENE

Alternate Names: C1717 NCI drug code

Drug Info:

Publications: Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.

NCI: HMAF

Alternate Names: C1717 NCI drug code

Drug Info:

Publications: Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.

ChemblDrugs: chembl:CHEMBL118218

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17229870

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12014623

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9195958

Sources:
NCI

Alternate Names:

C1717 NCI drug code

Publications:

Wiltshire et al., 2007, BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven., Mol. Pharmacol.

Alternate Names:

C1717 NCI drug code

Publications:

Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.

Alternate Names:

C1717 NCI drug code

Publications:

Marini et al., 1997, hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2., J. Biol. Chem.