DGIdb - ITRACONAZOLE Drug Record

ITRACONAZOLE chembl:CHEMBL64391 Approved

Alternate Names:

SPORANOX I.V.
SPORANOX-PULSE
TOLSURA
ITRACONAZOLE
ONMEL
SPORANOX
R-51211
ITRAZOLE
SPORANOS

Drug Info:

(2 More Sources)

Publications:

Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
Shi W et al., 2011, Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling., J Med Chem
Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.
Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki
Korashy et al., 2007, Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection., Cancer Lett.

ITRACONAZOLE HMGB1

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14639950

Sources:
NCI
ITRACONAZOLE AVPR2

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
ITRACONAZOLE NQO1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17923278

Sources:
NCI
ITRACONAZOLE IL2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1330944

Sources:
NCI
ITRACONAZOLE ABCG2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17518356

Sources:
NCI
ITRACONAZOLE KDR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21936514

Sources:
DTC
ITRACONAZOLE ABCB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15969931

Sources:
NCI PharmGKB
ITRACONAZOLE HSP90AA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ITRACONAZOLE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ITRACONAZOLE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

DTC: ITRACONAZOLE

Version: 02-September-2020

Alternate Names:

CHEMBL22587 ChEMBL Drug ID

Drug Info:

Publications:

Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem

Shi W et al., 2011, Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling., J Med Chem

NCI: ITRACONAZOLE

Version: 14-September-2017

Alternate Names:

C1138 NCI drug code

Drug Info:

Publications:

Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci

Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.

Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.

PharmGKB: itraconazole
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Itraconazole
- Version: 2020.06.01
Alternate Names:

D0V4IB TTD Drug ID

Drug Info:

Publications:
DTC: ITRAZOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL64391 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL64391
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

ITRACONAZOLE Drug Record

ITRACONAZOLE chembl:CHEMBL64391 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14639950

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17923278

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1330944

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17518356

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21936514

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15969931

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

DTC: ITRACONAZOLE

Alternate Names: CHEMBL22587 ChEMBL Drug ID

Drug Info:

NCI: ITRACONAZOLE

Alternate Names: C1138 NCI drug code

Drug Info:

PharmGKB: itraconazole

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Itraconazole

Alternate Names: D0V4IB TTD Drug ID

Drug Info:

Publications:

DTC: ITRAZOLE

Alternate Names: CHEMBL64391 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL64391

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
14639950

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17923278

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1330944

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17518356

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21936514

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15969931

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

CHEMBL22587 ChEMBL Drug ID

Alternate Names:

C1138 NCI drug code

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D0V4IB TTD Drug ID

Alternate Names:

CHEMBL64391 ChEMBL Drug ID