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ITRACONAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • ITRACONAZOLE chembl:CHEMBL64391 Approved

    Alternate Names:

    SPORANOX I.V.
    SPORANOX-PULSE
    TOLSURA
    ITRACONAZOLE
    ONMEL
    SPORANOX
    R-51211
    ITRAZOLE
    SPORANOS

    Drug Info:

    (2 More Sources)

    Publications:

    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.
    Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
    Shi W et al., 2011, Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling., J Med Chem
    Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.
    Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki
    Korashy et al., 2007, Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection., Cancer Lett.
  • ITRACONAZOLE   HMGB1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14639950


    Sources:
    NCI

  • ITRACONAZOLE   AVPR2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • ITRACONAZOLE   NQO1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17923278


    Sources:
    NCI

  • ITRACONAZOLE   IL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1330944


    Sources:
    NCI

  • ITRACONAZOLE   ABCG2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17518356


    Sources:
    NCI

  • ITRACONAZOLE   KDR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21936514


    Sources:
    DTC

  • ITRACONAZOLE   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15969931


    Sources:
    NCI PharmGKB

  • ITRACONAZOLE   HSP90AA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ITRACONAZOLE   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ITRACONAZOLE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • DTC: ITRACONAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL22587 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
    Shi W et al., 2011, Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling., J Med Chem

  • NCI: ITRACONAZOLE

    • Version: 14-September-2017

    Alternate Names:
    C1138 NCI drug code

    Drug Info:

    Publications:
    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
    Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.
    Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.

  • PharmGKB: itraconazole

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Itraconazole

    • Version: 2020.06.01

    Alternate Names:
    D0V4IB TTD Drug ID

    Drug Info:

    Publications:

  • DTC: ITRAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL64391 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL64391

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21