DGIdb - KETAMINE Drug Record

KETAMINE chembl:CHEMBL742 Approved

Alternate Names:

KETAMINE
KETALAR
NSC-70151

Drug Info:

Drug Class	anesthetics
Year of Approval	1970
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic

(3 More Sources)

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem
Smothers et al., 2007, Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits., J. Pharmacol. Exp. Ther.
Radovanović et al., [Ketamine: the past 30 years and its future]., Med. Pregl.
Sinner et al., 2008, Ketamine., Handb Exp Pharmacol
Harrison et al., 1985, Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex., Br. J. Pharmacol.
Li Y et al., 2015, CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects., Br J Clin Pharmacol
Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

KETAMINE GRIN3A

Interaction Score: 1.82

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name nasal ketamine,Ereska

PMIDs:
17502428 14740534 18175098 2858237

Sources:
TdgClinicalTrial TEND
KETAMINE GRIN2A

Interaction Score: 0.78

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20361801

Sources:
DTC GuideToPharmacology
KETAMINE CYP2B6

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25702819 11470993 17638512

Sources:
PharmGKB
KETAMINE GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20361801

Sources:
DTC
KETAMINE GRIN2D

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology

KETAMINE GRIN2C

Interaction Score: 0.27

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

KETAMINE GRIN2B

Interaction Score: 0.2

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

TdgClinicalTrial: KETAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: KETAMINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1970

Drug Class anesthetics

Publications:
DTC: KETAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL742 ChEMBL Drug ID

Drug Info:

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

PharmGKB: ketamine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Li Y et al., 2015, CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects., Br J Clin Pharmacol

Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics

TTD: Ketamine
- Version: 2020.06.01
Alternate Names:

D0UM7O TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL742
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 178101050
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	amitriptyline + ketamine,Epicept NP-1
Novel drug target	Established target
Trial Name	nasal ketamine,Ereska

Specific Action of the Ligand	None
Endogenous Drug?	False
Direct Interaction?	True

Details of the Assay for Interaction	Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
Specific Action of the Ligand	None
Endogenous Drug?	False

KETAMINE Drug Record

KETAMINE chembl:CHEMBL742 Approved

Alternate Names:

Drug Info:

Publications:

KETAMINE GRIN3A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name amitriptyline + ketamine,Epicept NP-1 Novel drug target Established target Trial Name nasal ketamine,Ereska

PMIDs: 17502428 14740534 18175098 2858237

Sources: TdgClinicalTrial TEND

KETAMINE GRIN2A

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? True

PMIDs: 20361801

Sources: DTC GuideToPharmacology

KETAMINE CYP2B6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25702819 11470993 17638512

Sources: PharmGKB

KETAMINE GRIN1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20361801

Sources: DTC

KETAMINE GRIN2D

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand None

PMIDs: None found

Sources: GuideToPharmacology

KETAMINE GRIN2C

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9 Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

KETAMINE GRIN2B

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

TdgClinicalTrial: KETAMINE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

TEND: KETAMINE

Alternate Names:

Drug Info: Year of Approval 1970 Drug Class anesthetics

Publications:

DTC: KETAMINE

Alternate Names: CHEMBL742 ChEMBL Drug ID

Drug Info:

Publications: Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

PharmGKB: ketamine

Alternate Names:

Drug Info:

TTD: Ketamine

Alternate Names: D0UM7O TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL742

Alternate Names:

Drug Info:

Publications:

GuideToPharmacology: 178101050

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name nasal ketamine,Ereska

PMIDs:
17502428 14740534 18175098 2858237

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20361801

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25702819 11470993 17638512

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20361801

Sources:
DTC

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Year of Approval 1970

Drug Class anesthetics

Alternate Names:

CHEMBL742 ChEMBL Drug ID

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

Alternate Names:

D0UM7O TTD Drug ID