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LARGAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • LARGAZOLE chembl:CHEMBL1173445

    Alternate Names:

    LARGAZOLE

    Drug Info:

    (0 More Sources)

    Publications:

    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem
    Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
  • LARGAZOLE   HDAC11

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC6

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 20491440 21936551 25203782


    Sources:
    DTC

  • LARGAZOLE   HDAC9

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440 21420302 25203782


    Sources:
    DTC

  • LARGAZOLE   HDAC10

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC7

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC5

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC8

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 21936551 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC3

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   HDAC4

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA3C

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB4A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   E2F1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LARGAZOLE   TUBA1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA3E

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA1C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBA1A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   RB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LARGAZOLE   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • LARGAZOLE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • DTC: LARGAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1173445 ChEMBL Drug ID

    Drug Info:

    Publications:
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem

  • ChemblDrugs: chembl:CHEMBL1173445

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21