DGIdb - LARGAZOLE Drug Record

LARGAZOLE chembl:CHEMBL1173445

Alternate Names:

LARGAZOLE

Drug Info:

(0 More Sources)

Publications:

Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

LARGAZOLE HDAC11

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC6

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 20491440 21936551 25203782

Sources:
DTC
LARGAZOLE HDAC9

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440 21420302 25203782

Sources:
DTC
LARGAZOLE HDAC10

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC7

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC5

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC8

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 21936551 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE HDAC4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
LARGAZOLE TUBA3C

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB4A

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE E2F1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LARGAZOLE TUBA1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB6

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB2B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBA3D

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBA3E

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB8

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBA1C

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB2A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE RB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LARGAZOLE TUBB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
LARGAZOLE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC

DTC: LARGAZOLE

Version: 02-September-2020

Alternate Names:

CHEMBL1173445 ChEMBL Drug ID

Drug Info:

Publications:

Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem

Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem

Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem

ChemblDrugs: chembl:CHEMBL1173445
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

LARGAZOLE Drug Record

LARGAZOLE chembl:CHEMBL1173445

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 20491440 21936551 25203782

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440 21420302 25203782

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 21936551 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21420302 25203782 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20491440

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 20491440 21936551 25203782

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440 21420302 25203782

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 21936551 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20491440

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found