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LEVOMEPROMAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • LEVOMEPROMAZINE chembl:CHEMBL1764 Approved

    Alternate Names:

    XP03
    NSC-226516
    METHOTRIMEPRAZINE
    NIRVAN
    CL-39743
    XP-03
    N05AA02
    LEVOMEPROMAZINE
    SK&F-5116
    TISERCIN
    CL-36467
    RP-7044
    LEVOPROME
    NOSINAN®
    LEVOMEPROMAZINUM
    (-)-10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-2-METHOXYPHENOTHIAZINE
    LEVOPROME®
    NOZINAN®
    (-)-(2R)-3-(2-METHOXY-10H-PHENOTHIAZIN-10-YL)-N,N,2-TRIMETHYLPROPAN-1-AMINE
    LEVOMEPROMAZINA
    2-METHOXYTRIMEPRAZINE
    rxcui:6852
    chembl:CHEMBL1764
    pubchem.compound:72287
    chemidplus:60-99-1
    drugbank:01403

    Drug Info:

    Year of Approval not approved by the fda
    Drug Class antipsychotic agents
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    (2 More Sources)

    Publications:

    Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Thümmler S et al., 2018, Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6., Front Psychiatry
    Vevelstad M et al., 2009, O-demethylation of codeine to morphine inhibited by low-dose levomepromazine., Eur J Clin Pharmacol
  • LEVOMEPROMAZINE   CHRM4

    Interaction Score: 0.8

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   ADRA1D

    Interaction Score: 0.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15701205 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   HTR2B

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   CHRM5

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   CHRM2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   ADRA1B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15701205 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   DRD3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction D2-like dopamine receptor antagonist

    PMIDs:
    15701205


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • LEVOMEPROMAZINE   CHRM3

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   DRD4

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    15701205


    Sources:
    ChemblInteractions

  • LEVOMEPROMAZINE   CHRM1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   ADRA1A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15701205 2870716


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   DRD2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    10592235 15701205 2870716


    Sources:
    ChemblInteractions TTD

  • LEVOMEPROMAZINE   HRH1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29472872 19308365


    Sources:
    PharmGKB

  • TEND: METHOTRIMEPRAZINE

    • Version: 01-August-2011

    Alternate Names:
    METHOTRIMEPRAZINE Primary Drug Name

    Drug Info:
    Drug Class antipsychotic agents
    Year of Approval not approved by the fda

    Publications:

  • TdgClinicalTrial: METHOTRIMEPRAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antipsychotic Agents
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • PharmGKB: levomepromazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Vevelstad M et al., 2009, O-demethylation of codeine to morphine inhibited by low-dose levomepromazine., Eur J Clin Pharmacol
    Thümmler S et al., 2018, Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6., Front Psychiatry

  • TTD: Levomepromazine

    • Version: 2020.06.01

    Alternate Names:
    D09LZT TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1764

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1764

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21