DGIdb - LEVOMEPROMAZINE Drug Record

LEVOMEPROMAZINE chembl:CHEMBL1764 Approved

Alternate Names:

XP03
NSC-226516
METHOTRIMEPRAZINE
NIRVAN
CL-39743
XP-03
N05AA02
LEVOMEPROMAZINE
SK&F-5116
TISERCIN
CL-36467
RP-7044
LEVOPROME
NOSINAN®
LEVOMEPROMAZINUM
(-)-10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-2-METHOXYPHENOTHIAZINE
LEVOPROME®
NOZINAN®
(-)-(2R)-3-(2-METHOXY-10H-PHENOTHIAZIN-10-YL)-N,N,2-TRIMETHYLPROPAN-1-AMINE
LEVOMEPROMAZINA
2-METHOXYTRIMEPRAZINE
rxcui:6852
chembl:CHEMBL1764
pubchem.compound:72287
chemidplus:60-99-1
drugbank:01403

Drug Info:

Year of Approval	not approved by the fda
Drug Class	antipsychotic agents
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antipsychotic Agents

(2 More Sources)

Publications:

Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Thümmler S et al., 2018, Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6., Front Psychiatry
Vevelstad M et al., 2009, O-demethylation of codeine to morphine inhibited by low-dose levomepromazine., Eur J Clin Pharmacol

LEVOMEPROMAZINE CHRM4

Interaction Score: 0.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE ADRA1D

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE HTR2B

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE CHRM5

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE CHRM2

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE ADRA1B

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE DRD3

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
15701205

Sources:
TdgClinicalTrial ChemblInteractions TEND
LEVOMEPROMAZINE CHRM3

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
15701205

Sources:
ChemblInteractions
LEVOMEPROMAZINE CHRM1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE DRD2

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
10592235 15701205 2870716

Sources:
ChemblInteractions TTD
LEVOMEPROMAZINE HRH1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29472872 19308365

Sources:
PharmGKB

TEND: METHOTRIMEPRAZINE
- Version: 01-August-2011
Alternate Names:

METHOTRIMEPRAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: METHOTRIMEPRAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:

PharmGKB: levomepromazine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Vevelstad M et al., 2009, O-demethylation of codeine to morphine inhibited by low-dose levomepromazine., Eur J Clin Pharmacol

Thümmler S et al., 2018, Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6., Front Psychiatry

TTD: Levomepromazine
- Version: 2020.06.01
Alternate Names:

D09LZT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1764
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1764
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	D2-like dopamine receptor antagonist

Mechanism of Interaction	D2-like dopamine receptor antagonist
Direct Interaction	yes

LEVOMEPROMAZINE Drug Record

LEVOMEPROMAZINE chembl:CHEMBL1764 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2899826 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 15701205 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2899826 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2899826 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15701205 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs: 15701205

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2899826 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes

PMIDs: 15701205

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2899826 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15701205 2870716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes

PMIDs: 10592235 15701205 2870716

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2899826

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29472872 19308365

Sources: PharmGKB

TEND: METHOTRIMEPRAZINE

Alternate Names: METHOTRIMEPRAZINE Primary Drug Name

Drug Info: Drug Class antipsychotic agents Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: METHOTRIMEPRAZINE

Alternate Names:

Drug Info: Drug Indications Antipsychotic Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

PharmGKB: levomepromazine

Alternate Names:

Drug Info:

TTD: Levomepromazine

Alternate Names: D09LZT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1764

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
15701205

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
15701205

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
10592235 15701205 2870716

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
29472872 19308365

Sources:
PharmGKB

Alternate Names:

METHOTRIMEPRAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D09LZT TTD Drug ID