DGIdb - LIOTHYRONINE Drug Record

LIOTHYRONINE chembl:CHEMBL1544 Approved

Alternate Names:

EUTHROID-1
EUTHROID-2
THYROLAR-0.5
THYROLAR-1
EUTHROID-0.5
CYTOMEL
TERTROXIN
EUTHROID-3
TRIOSTAT
NSC-80203
THYROLAR-0.25
THYROLAR-2
LIOTHYRONINE
THYROLAR-5
THYROLAR-3
RATHYRONINE
TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%)
3,5,3'-TRIODO-L-THYRONINE
O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE
LIOTHYRONINE SODIUM
LIOTHYRONINUM
3,3',5-TRIIODO-L-THYRONINE
T3
3,5,3'-TRIIODO-L-THYRONINE
3,5,3'-TRIIODOTHYRONINE
L-3,5,3'-TRIIODOTHYRONINE
TRESITOPE
CYTOMEL®
TRIIODOTHYRONINE
3,5,3'TRIIODOTHYRONINE
4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODO-L-PHENYLALANINE
LIOTIRONINA
L-T3
chemidplus:6893-02-3
chembl:CHEMBL1544
drugbank:00279
pubchem.compound:5920
rxcui:10814

Drug Info:

Year of Approval	1956
Drug Class	hormone replacement agents
FDA Approval	1956
Drug Class	small molecule
Drug Indications	Hormone Replacement Agents

(3 More Sources)

Publications:

Kullak-Ublick et al., 2001, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver., Gastroenterology
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Yen et al., 2003, Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice., EMBO Rep.
Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
González-Sancho et al., 2003, Thyroid hormone receptors/THR genes in human cancer., Cancer Lett.
Wu et al., 2005, Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T)., J. Lab. Clin. Med.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Mai et al., 2004, Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life., Proc. Natl. Acad. Sci. U.S.A.
Timmer et al., 2003, Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA., J. Endocrinol.
Sciaudone et al., 2004, Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism., Biol Trace Elem Res
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Jiang et al., 2004, Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation., J. Endocrinol.
Kariv et al., 2003, Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line., Liver Int.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

LIOTHYRONINE THRA

Interaction Score: 8.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
15240882 14596673 15235154 11752352 15283690 12955882

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
LIOTHYRONINE THRB

Interaction Score: 0.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
LIOTHYRONINE HTR1B

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
LIOTHYRONINE CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LIOTHYRONINE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LIOTHYRONINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LIOTHYRONINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LIOTHYRONINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: LIOTHYRONINE
- Version: 01-August-2011
Alternate Names:

LIOTHYRONINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval 1956

Publications:
TdgClinicalTrial: LIOTHYRONINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval 1956

Publications:
DTC: LIOTHYRONINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1544 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: liothyronine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
TTD: Liothyronine
- Version: 2020.06.01
Alternate Names:

D0S6JG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1544
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1544
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thyroid hormone receptor agonist
Direct Interaction	yes
Trial Name	-

Trial Name	-
Novel drug target	Established target
Direct Interaction	yes

LIOTHYRONINE Drug Record

LIOTHYRONINE chembl:CHEMBL1544 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thyroid hormone receptor agonist Direct Interaction yes Trial Name -

PMIDs: 15240882 14596673 15235154 11752352 15283690 12955882

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: LIOTHYRONINE

Alternate Names: LIOTHYRONINE Primary Drug Name

Drug Info: Drug Class hormone replacement agents Year of Approval 1956

Publications:

TdgClinicalTrial: LIOTHYRONINE

Alternate Names:

Drug Info: Drug Indications Hormone Replacement Agents Drug Class small molecule FDA Approval 1956

Publications:

DTC: LIOTHYRONINE

Alternate Names: CHEMBL1544 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: liothyronine

Alternate Names:

Drug Info:

Publications: Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

TTD: Liothyronine

Alternate Names: D0S6JG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1544

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1544

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
15240882 14596673 15235154 11752352 15283690 12955882

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

LIOTHYRONINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval 1956

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval 1956

Alternate Names:

CHEMBL1544 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

Alternate Names:

D0S6JG TTD Drug ID