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LIOTHYRONINE Drug Record

  • Summary
  • Interactions
  • Claims
  • LIOTHYRONINE chembl:CHEMBL1544 Approved

    Alternate Names:

    EUTHROID-1
    EUTHROID-2
    THYROLAR-0.5
    THYROLAR-1
    EUTHROID-0.5
    CYTOMEL
    TERTROXIN
    EUTHROID-3
    TRIOSTAT
    NSC-80203
    THYROLAR-0.25
    THYROLAR-2
    LIOTHYRONINE
    THYROLAR-5
    THYROLAR-3
    RATHYRONINE
    TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%)
    3,5,3'-TRIODO-L-THYRONINE
    O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE
    LIOTHYRONINE SODIUM
    LIOTHYRONINUM
    3,3',5-TRIIODO-L-THYRONINE
    T3
    3,5,3'-TRIIODO-L-THYRONINE
    3,5,3'-TRIIODOTHYRONINE
    L-3,5,3'-TRIIODOTHYRONINE
    TRESITOPE
    CYTOMEL®
    TRIIODOTHYRONINE
    3,5,3'TRIIODOTHYRONINE
    4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODO-L-PHENYLALANINE
    LIOTIRONINA
    L-T3
    chemidplus:6893-02-3
    chembl:CHEMBL1544
    drugbank:00279
    pubchem.compound:5920
    rxcui:10814

    Drug Info:

    Year of Approval 1956
    Drug Class hormone replacement agents
    FDA Approval 1956
    Drug Class small molecule
    Drug Indications Hormone Replacement Agents
    (3 More Sources)

    Publications:

    Kullak-Ublick et al., 2001, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver., Gastroenterology
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Yen et al., 2003, Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice., EMBO Rep.
    Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
    González-Sancho et al., 2003, Thyroid hormone receptors/THR genes in human cancer., Cancer Lett.
    Wu et al., 2005, Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T)., J. Lab. Clin. Med.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Mai et al., 2004, Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life., Proc. Natl. Acad. Sci. U.S.A.
    Timmer et al., 2003, Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA., J. Endocrinol.
    Sciaudone et al., 2004, Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism., Biol Trace Elem Res
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jiang et al., 2004, Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation., J. Endocrinol.
    Kariv et al., 2003, Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line., Liver Int.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
  • LIOTHYRONINE   THRA

    Interaction Score: 8.59

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thyroid hormone receptor agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    15240882 14596673 15235154 11752352 15283690 12955882


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • LIOTHYRONINE   THRB

    Interaction Score: 0.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • LIOTHYRONINE   HTR1B

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • LIOTHYRONINE   CYP2C9

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • LIOTHYRONINE   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • LIOTHYRONINE   CYP1A2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • LIOTHYRONINE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • LIOTHYRONINE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: LIOTHYRONINE

    • Version: 01-August-2011

    Alternate Names:
    LIOTHYRONINE Primary Drug Name

    Drug Info:
    Drug Class hormone replacement agents
    Year of Approval 1956

    Publications:

  • TdgClinicalTrial: LIOTHYRONINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hormone Replacement Agents
    Drug Class small molecule
    FDA Approval 1956

    Publications:

  • DTC: LIOTHYRONINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1544 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: liothyronine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

  • TTD: Liothyronine

    • Version: 2020.06.01

    Alternate Names:
    D0S6JG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1544

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1544

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21