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LIOTHYRONINE SODIUM Drug Record

  • Summary
  • Interactions
  • Claims
  • LIOTHYRONINE SODIUM chembl:CHEMBL1201119 Approved

    Alternate Names:

    TRIIODOTHYRONINE,EVANS
    THYBON
    NSC-80774
    LIOTHYRONINE SODIUM SALT
    TRIOSTAT
    LIOTHYRONINE SODIUM
    T3 (LIOTRIX)
    TRIIODOTHYRONINE
    CYTOMEL
    TRIIODOTHYRONINE SODIUM, LEVO
    TERTROXIN
    CYNOMEL
    chembl:CHEMBL1201119
    chemidplus:55-06-1
    rxcui:142448
    pubchem.compound:23666110

    Drug Info:

    (0 More Sources)

    Publications:

    Debeljuk et al., 1999, Transgenic mice overexpressing the growth-hormone-releasing hormone gene have high concentrations of tachykinins in the anterior pituitary gland., Neuroendocrinology
    Akuzawa et al., 1985, A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol., Endocrinol. Jpn.
    Lehrer et al., Elevated serum triiodothyronine (t3) in Ashkenazi Jewish prostate cancer patients carrying the I1307k allele of the APC (adenopolyposis coli) gene., Urol. Oncol.
    Manna et al., 2001, Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function., Endocrinology
    Severson et al., 1984, Hormonal regulation of acid cholesterol ester hydrolase activity: effects of triiodothyronine and 17 alpha-ethynylestradiol., Can. J. Physiol. Pharmacol.
    Masaki et al., 1997, Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone., FEBS Lett.
    Jekabsons et al., 1999, T(3) stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice., Am. J. Physiol.
    Busson et al., 2006, Avian MyoD and c-Jun coordinately induce transcriptional activity of the 3,5,3'-triiodothyronine nuclear receptor c-ErbAalpha1 in proliferating myoblasts., Endocrinology
    Leingärtner et al., 1994, Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons., J. Biol. Chem.
    Xiong et al., 1998, Identification of thyroid hormone response elements in the human fatty acid synthase promoter., Proc. Natl. Acad. Sci. U.S.A.
    Chan et al., 1986, Inhibition of follicle-stimulating hormone induction of aromatase activity in porcine granulosa cells by thyroxine and triiodothyronine., Endocrinology
    Goto et al., 1997, Effect of triiodothyronine on glucose transport in rat adipocytes., Life Sci.
    Jørgensen et al., 1986, Development of neuronal markers in aggregating fetal rat telencephalon cells cultured in the presence of triiodothyronine., Int. J. Dev. Neurosci.
    Degerman et al., 2002, Local action of estrogen and thyroid hormone on vasoactive intestinal peptide (VIP) and galanin gene expression in the rat anterior pituitary., Neuropeptides
    Ehrchen et al., 2001, Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary., J. Endocrinol.
    Demori et al., 1995, Triiodothyronine decreases gammaglutamyltranspeptidase expression in cultured rat hepatocytes., Horm. Metab. Res.
    Fernández et al., 1997, Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat., Nitric Oxide
    Demori et al., Regulation of IGFBP-1 and -4 expression by triiodothyronine (T3) in cultured hepatocytes is cell- and gene-specific., Boll. Soc. Ital. Biol. Sper.
    Jump et al., 1993, Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes., Proc. Natl. Acad. Sci. U.S.A.
    Hiroi et al., 2006, Rapid nongenomic actions of thyroid hormone., Proc. Natl. Acad. Sci. U.S.A.
  • LIOTHYRONINE SODIUM   TAC3

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10461025


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   UCP2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9428737 10444435


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   THRSP

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8378318


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   GAL

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12147214


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   LIPA

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6713293


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   ENO2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3455610


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   IGFBP1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9540232


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   MYOD1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16556763


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NR5A1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11145595


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   CHAT

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4017971


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NTF3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8288635


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   GGT1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7642172


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   THRA

    Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thyroid hormone receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIOTHYRONINE SODIUM   CCN2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11250650


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   APC

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856637


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   FASN

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9770474


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   CYP19A1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3095107


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   NOS1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9466951


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   SLC2A4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9217278


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8288635


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16966610


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   MCL1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   THRB

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thyroid hormone receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIOTHYRONINE SODIUM   BLM

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   POLB

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   BAZ2B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   ALDH1A1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   GMNN

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: TRIIODOTHYRONINE

    • Version: 14-September-2017

    Alternate Names:
    C907 NCI drug code

    Drug Info:

    Publications:
    Busson et al., 2006, Avian MyoD and c-Jun coordinately induce transcriptional activity of the 3,5,3'-triiodothyronine nuclear receptor c-ErbAalpha1 in proliferating myoblasts., Endocrinology
    Degerman et al., 2002, Local action of estrogen and thyroid hormone on vasoactive intestinal peptide (VIP) and galanin gene expression in the rat anterior pituitary., Neuropeptides
    Fernández et al., 1997, Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat., Nitric Oxide

  • DTC: LIOTHYRONINE SODIUM

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1201119 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1201119

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201119

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21