• Interaction Score: 1.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name lofexidine,BritLofex
    Novel drug target Established target
    Details of the Assay for Interaction Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2A</sub>-AR.

  • Interaction Score: 0.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name lofexidine,BritLofex
    Details of the Assay for Interaction Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2C</sub>-AR.

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

    • Version: 01-August-2011

    Alternate Names:
    LOFEXIDINE Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval not approved by the fda
    Drug Class treatment for opiate withdrawal

    Publications:

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of opiate withdrawal
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    D0K0MW TTD Drug ID

    Drug Info:

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    LOFEXIDINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications: