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LORATADINE Drug Record

  • Summary
  • Interactions
  • Claims
  • LORATADINE chembl:CHEMBL998 Approved

    Alternate Names:

    CLARITIN
    CLARITIN HIVES RELIEF REDITAB
    LORATADINE
    CLARITIN HIVES RELIEF
    CLARITYNE
    CLARITIN-D
    CLARITYN
    SCH-29851
    HAY-RITE
    LORATADINE REDIDOSE
    CHILDREN'S CLARITIN
    ROLETRA
    CLARITIN REDITABS
    CLARITYN RAPIDE
    ALAVERT
    LORATADINA
    LORATADINUM
    CLARITIN®
    pubchem.compound:3957
    drugbank:00455
    chembl:CHEMBL998
    chemidplus:79794-75-5
    rxcui:28889

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiasthmatic agent
    Year of Approval 1993
    Drug Class anti-allergic agents
    (4 More Sources)

    Publications:

    Cuboni S et al., 2014, Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2., J Med Chem
    Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Tamura et al., 2005, Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice., Pharmacology
    Baroody et al., 2000, Antiallergic effects of H1-receptor antagonists., Allergy
    Cieślewicz et al., 1995, [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
    Cieślewicz et al., 1992, [Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics]., Pneumonol Alergol Pol
    Menardo et al., A review of loratadine in the treatment of patients with allergic bronchial asthma., Clin Ther
    Letari et al., 1994, Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Howarth, 1990, Histamine and asthma: an appraisal based on specific H1-receptor antagonism., Clin. Exp. Allergy
    Grzelewska-Rzymowska et al., 1992, [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
    Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
    Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.
    García et al., 1997, Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells., Am. J. Vet. Res.
    Van Neste et al., 1992, Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P., J. Dermatol. Sci.
    Traidl-Hoffmann et al., 2006, Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines., Int. Arch. Allergy Immunol.
  • LORATADINE   SLC6A15

    Interaction Score: 7.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25318072


    Sources:
    DTC

  • LORATADINE   CCL17

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16741367


    Sources:
    NCI

  • LORATADINE   KCNA5

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9271355


    Sources:
    NCI

  • LORATADINE   TAC1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9055977 1283698


    Sources:
    NCI

  • LORATADINE   HRH1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histamine H1 receptor antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    15942272 11291777 7581058 1303772 9444440 8174605 11752352 1977506 1303773 10597865


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • LORATADINE   MPO

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17159802


    Sources:
    NCI

  • LORATADINE   CYP3A5

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • LORATADINE   NPSR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   TSHR

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   HIF1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: LORATADINE

    • Version: 01-August-2011

    Alternate Names:
    LORATADINE Primary Drug Name

    Drug Info:
    Drug Class anti-allergic agents
    Year of Approval 1993

    Publications:

  • TdgClinicalTrial: LORATADINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiasthmatic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: LORATADINE

    • Version: 14-September-2017

    Alternate Names:
    C29162 NCI drug code

    Drug Info:

    Publications:
    Traidl-Hoffmann et al., 2006, Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines., Int. Arch. Allergy Immunol.
    Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.
    Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.

  • DTC: LORATADINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL998 ChEMBL Drug ID

    Drug Info:

    Publications:
    Cuboni S et al., 2014, Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2., J Med Chem

  • PharmGKB: loratadine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • TTD: Loratadine

    • Version: 2020.06.01

    Alternate Names:
    D06ABF TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL998

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL998

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21