DGIdb - LORATADINE Drug Record

LORATADINE chembl:CHEMBL998 Approved

Alternate Names:

CLARITIN
CLARITIN HIVES RELIEF REDITAB
LORATADINE
CLARITIN HIVES RELIEF
CLARITYNE
CLARITIN-D
CLARITYN
SCH-29851
HAY-RITE
LORATADINE REDIDOSE
CHILDREN'S CLARITIN
ROLETRA
CLARITIN REDITABS
CLARITYN RAPIDE
ALAVERT
LORATADINA
LORATADINUM
CLARITIN®
pubchem.compound:3957
drugbank:00455
chembl:CHEMBL998
chemidplus:79794-75-5
rxcui:28889

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiasthmatic agent
Year of Approval	1993
Drug Class	anti-allergic agents

(4 More Sources)

Publications:

Cuboni S et al., 2014, Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2., J Med Chem
Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Tamura et al., 2005, Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice., Pharmacology
Baroody et al., 2000, Antiallergic effects of H1-receptor antagonists., Allergy
Cieślewicz et al., 1995, [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
Cieślewicz et al., 1992, [Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics]., Pneumonol Alergol Pol
Menardo et al., A review of loratadine in the treatment of patients with allergic bronchial asthma., Clin Ther
Letari et al., 1994, Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Howarth, 1990, Histamine and asthma: an appraisal based on specific H1-receptor antagonism., Clin. Exp. Allergy
Grzelewska-Rzymowska et al., 1992, [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.
García et al., 1997, Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells., Am. J. Vet. Res.
Van Neste et al., 1992, Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P., J. Dermatol. Sci.
Traidl-Hoffmann et al., 2006, Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines., Int. Arch. Allergy Immunol.

LORATADINE SLC6A15

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25318072

Sources:
DTC
LORATADINE CCL17

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16741367

Sources:
NCI
LORATADINE KCNA5

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9271355

Sources:
NCI
LORATADINE TAC1

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9055977 1283698

Sources:
NCI
LORATADINE HRH1

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H1 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
15942272 11291777 7581058 1303772 9444440 8174605 11752352 1977506 1303773 10597865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
LORATADINE MPO

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17159802

Sources:
NCI
LORATADINE CYP3A5

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
LORATADINE NPSR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE TSHR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE HIF1A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: LORATADINE
- Version: 01-August-2011
Alternate Names:

LORATADINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1993

Publications:
TdgClinicalTrial: LORATADINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiasthmatic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: LORATADINE

Version: 14-September-2017

Alternate Names:

C29162 NCI drug code

Drug Info:

Publications:

Traidl-Hoffmann et al., 2006, Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines., Int. Arch. Allergy Immunol.

Nosál' et al., 2006, On the pharmacology and toxicology of neutrophils., Neuro Endocrinol. Lett.

Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.

DTC: LORATADINE
- Version: 02-September-2020
Alternate Names:

CHEMBL998 ChEMBL Drug ID

Drug Info:

Publications:

Cuboni S et al., 2014, Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2., J Med Chem
PharmGKB: loratadine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
TTD: Loratadine
- Version: 2020.06.01
Alternate Names:

D06ABF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL998
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL998
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Histamine H1 receptor antagonist
Direct Interaction	yes
Novel drug target	Established target

LORATADINE Drug Record

LORATADINE chembl:CHEMBL998 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25318072

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16741367

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9271355

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9055977 1283698

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Histamine H1 receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: 15942272 11291777 7581058 1303772 9444440 8174605 11752352 1977506 1303773 10597865

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17159802

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: LORATADINE

Alternate Names: LORATADINE Primary Drug Name

Drug Info: Drug Class anti-allergic agents Year of Approval 1993

Publications:

TdgClinicalTrial: LORATADINE

Alternate Names:

Drug Info: Drug Indications antiasthmatic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: LORATADINE

Alternate Names: C29162 NCI drug code

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25318072

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16741367

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9271355

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9055977 1283698

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H1 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
15942272 11291777 7581058 1303772 9444440 8174605 11752352 1977506 1303773 10597865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
17159802

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

LORATADINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1993

Drug Info:

Drug Indications antiasthmatic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29162 NCI drug code

Alternate Names:

CHEMBL998 ChEMBL Drug ID

Publications:

Cuboni S et al., 2014, Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2., J Med Chem

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

D06ABF TTD Drug ID