DGIdb - MELATONIN Drug Record

MELATONIN chembl:CHEMBL45 Approved

Alternate Names:

LIFE EXT
J5.258B
HEALTH AID
BCI-049
NATURE'S BLEND
VESPRO
VYTALONIN
HEIDADOUPPI
MELATONIN
TRAVELAG
QUALITY HEALTH
GENERAL NUTRIT
NSC-113928
N-(2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
N-ACETYL-5-METHOXYTRYPTAMINE
MELAPURE
CIRCADIN
NSC-56423
NATURES BOUNTY
NATROL
ICENIA
S.GARD
{N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-} ACETAMIDE
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-ACETAMIDE
MLT
REGULIN
MELATONIN (SYNTH.) STANDARD-GRADE
{N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-} ACETAMIDE
MELATONIN (SYNTH.) ULTRA-PURE
N-(2-(5-METHOXYINDOL-3-YL)ETHYL)ACETAMIDE
N-ACETYL-5-METHOXY-TRYPTAMINE MELATONINE
MT6
MELOVINE
N-(2-(5-METHOXYINDOL-3-YL)ETHYL)-ACETAMIDE
MELATOL
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-ACETAMIDE
5-METHOXY-N-ACETYLTRYPTAMINE
N-ACETYL-5-METHOXY-TRYPTAMINE
N-[2-(5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
chemidplus:73-31-4
rxcui:6711
drugbank:01065
chembl:CHEMBL45
pubchem.compound:896

Drug Info:

Drug Class	hypnotics and sedatives
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives

(2 More Sources)

Publications:

Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet
Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.
Srinivasan et al., 2010, Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs., Adv Ther
Carocci et al., 2010, Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors., Bioorg. Med. Chem.
Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors
Prendergast, 2010, MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus)., Endocrinology
Boutin et al., 2005, Molecular tools to study melatonin pathways and actions., Trends Pharmacol. Sci.
Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.
Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)
Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology
Johnston et al., 2005, Photoperiod regulates multiple gene expression in the suprachiasmatic nuclei and pars tuberalis of the Siberian hamster (Phodopus sungorus)., Eur. J. Neurosci.
Poirel et al., 2003, Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei., Neuroscience
Itoh et al., 1995, Melatonin and arylalkylamine N-acetyltransferase activity in the silkworm, Bombyx mori., Mol. Cell. Endocrinol.
Ganguly et al., 2005, Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205., Proc. Natl. Acad. Sci. U.S.A.
Johnston et al., 2004, Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal., Neuroscience
Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.
Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.
Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.
Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.
Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology
Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.
Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.

MELATONIN TMSB10

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12188030

Sources:
NCI
MELATONIN MTNR1A

Interaction Score: 4.76

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20827520 20674373 19449447 19966183 11752352 15992934 19463840

Sources:
TdgClinicalTrial TEND TTD
MELATONIN MTNR1B

Interaction Score: 4.76

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20827520 20674373 19449447 19966183 15992934 19463840

Sources:
TdgClinicalTrial TEND
MELATONIN PER1

Interaction Score: 3.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15978008 12895514

Sources:
NCI
MELATONIN AANAT

Interaction Score: 3.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8674865 15644438 15026119

Sources:
NCI
MELATONIN RORA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8702678 12595746

Sources:
NCI
MELATONIN GHRH

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8370132

Sources:
NCI
MELATONIN MAP2

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8829136

Sources:
NCI
MELATONIN GCLM

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10515588

Sources:
NCI
MELATONIN CYP3A43

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11554431

Sources:
NCI
MELATONIN CYP3A7

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11882353

Sources:
NCI
MELATONIN NQO2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19463840

Sources:
TTD
MELATONIN IFNG

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7722866

Sources:
NCI
MELATONIN BGLAP

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17349020

Sources:
NCI
MELATONIN GFAP

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10877823

Sources:
NCI
MELATONIN ALOX5

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10668425

Sources:
NCI
MELATONIN RARA

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15813899

Sources:
NCI
MELATONIN PRL

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8977440

Sources:
NCI
MELATONIN IL1B

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8077674

Sources:
NCI
MELATONIN TGFB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9649124

Sources:
NCI
MELATONIN MYC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7629697

Sources:
NCI
MELATONIN MAOB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9726430

Sources:
NCI
MELATONIN BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15205854

Sources:
NCI
MELATONIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16313502

Sources:
NCI
MELATONIN CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MELATONIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MELATONIN
- Version: 01-August-2011
Alternate Names:

MELATONIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: MELATONIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:

NCI: MELATONIN

Version: 14-September-2017

Alternate Names:

C632 NCI drug code

Drug Info:

Publications:

Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.

Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer

Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.

TTD: Melatonin
- Version: 2020.06.01
Alternate Names:

D0AN7B TTD Drug ID

Drug Info:

Publications:
DTC: MELATONIN
- Version: 02-September-2020
Alternate Names:

CHEMBL45 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL45
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

MELATONIN Drug Record

MELATONIN chembl:CHEMBL45 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12188030

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 20827520 20674373 19449447 19966183 11752352 15992934 19463840

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 20827520 20674373 19449447 19966183 15992934 19463840

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15978008 12895514

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8674865 15644438 15026119

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8702678 12595746

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8370132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8829136

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10515588

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11554431

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11882353

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19463840

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7722866

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17349020

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10877823

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10668425

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15813899

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8977440

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8077674

Interaction Types & Directionality:

n/a

PMIDs:
12188030

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20827520 20674373 19449447 19966183 11752352 15992934 19463840

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20827520 20674373 19449447 19966183 15992934 19463840

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
15978008 12895514

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8674865 15644438 15026119

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8702678 12595746

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8370132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8829136

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10515588

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11554431

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11882353

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19463840

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
7722866

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17349020

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10877823

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10668425

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15813899

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8977440

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8077674

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9649124

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7629697

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9726430

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15205854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16313502

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC