• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

MELATONIN Drug Record

  • Summary
  • Interactions
  • Claims
  • MELATONIN chembl:CHEMBL45 Approved

    Alternate Names:

    LIFE EXT
    J5.258B
    HEALTH AID
    BCI-049
    NATURE'S BLEND
    VESPRO
    VYTALONIN
    HEIDADOUPPI
    MELATONIN
    TRAVELAG
    QUALITY HEALTH
    GENERAL NUTRIT
    NSC-113928
    N-(2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
    N-ACETYL-5-METHOXYTRYPTAMINE
    MELAPURE
    CIRCADIN
    NSC-56423
    NATURES BOUNTY
    NATROL
    ICENIA
    S.GARD
    {N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-} ACETAMIDE
    N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
    N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-ACETAMIDE
    MLT
    REGULIN
    MELATONIN (SYNTH.) STANDARD-GRADE
    {N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-} ACETAMIDE
    MELATONIN (SYNTH.) ULTRA-PURE
    N-(2-(5-METHOXYINDOL-3-YL)ETHYL)ACETAMIDE
    N-ACETYL-5-METHOXY-TRYPTAMINE MELATONINE
    MT6
    MELOVINE
    N-(2-(5-METHOXYINDOL-3-YL)ETHYL)-ACETAMIDE
    MELATOL
    N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-ACETAMIDE
    5-METHOXY-N-ACETYLTRYPTAMINE
    N-ACETYL-5-METHOXY-TRYPTAMINE
    N-[2-(5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE
    N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
    chemidplus:73-31-4
    rxcui:6711
    drugbank:01065
    chembl:CHEMBL45
    pubchem.compound:896

    Drug Info:

    Drug Class hypnotics and sedatives
    Year of Approval not approved by the fda
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    (2 More Sources)

    Publications:

    Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet
    Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.
    Srinivasan et al., 2010, Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs., Adv Ther
    Carocci et al., 2010, Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors., Bioorg. Med. Chem.
    Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors
    Prendergast, 2010, MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus)., Endocrinology
    Boutin et al., 2005, Molecular tools to study melatonin pathways and actions., Trends Pharmacol. Sci.
    Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
    Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.
    Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
    Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)
    Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology
    Johnston et al., 2005, Photoperiod regulates multiple gene expression in the suprachiasmatic nuclei and pars tuberalis of the Siberian hamster (Phodopus sungorus)., Eur. J. Neurosci.
    Poirel et al., 2003, Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei., Neuroscience
    Itoh et al., 1995, Melatonin and arylalkylamine N-acetyltransferase activity in the silkworm, Bombyx mori., Mol. Cell. Endocrinol.
    Ganguly et al., 2005, Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205., Proc. Natl. Acad. Sci. U.S.A.
    Johnston et al., 2004, Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal., Neuroscience
    Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.
    Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.
    Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
    Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
    Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
    Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
    Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
    Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.
    Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
    Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.
    Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology
    Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.
    Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.
  • MELATONIN   TMSB10

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12188030


    Sources:
    NCI

  • MELATONIN   MTNR1A

    Interaction Score: 4.76

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    20827520 20674373 19449447 19966183 11752352 15992934 19463840


    Sources:
    TdgClinicalTrial TEND TTD

  • MELATONIN   MTNR1B

    Interaction Score: 4.76

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    20827520 20674373 19449447 19966183 15992934 19463840


    Sources:
    TdgClinicalTrial TEND

  • MELATONIN   PER1

    Interaction Score: 3.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15978008 12895514


    Sources:
    NCI

  • MELATONIN   AANAT

    Interaction Score: 3.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8674865 15644438 15026119


    Sources:
    NCI

  • MELATONIN   RORA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8702678 12595746


    Sources:
    NCI

  • MELATONIN   GHRH

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8370132


    Sources:
    NCI

  • MELATONIN   MAP2

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8829136


    Sources:
    NCI

  • MELATONIN   GCLM

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10515588


    Sources:
    NCI

  • MELATONIN   CYP3A43

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11554431


    Sources:
    NCI

  • MELATONIN   CYP3A7

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11882353


    Sources:
    NCI

  • MELATONIN   NQO2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19463840


    Sources:
    TTD

  • MELATONIN   IFNG

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7722866


    Sources:
    NCI

  • MELATONIN   BGLAP

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17349020


    Sources:
    NCI

  • MELATONIN   GFAP

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10877823


    Sources:
    NCI

  • MELATONIN   ALOX5

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10668425


    Sources:
    NCI

  • MELATONIN   RARA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813899


    Sources:
    NCI

  • MELATONIN   PRL

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8977440


    Sources:
    NCI

  • MELATONIN   IL1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8077674


    Sources:
    NCI

  • MELATONIN   TGFB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9649124


    Sources:
    NCI

  • MELATONIN   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7629697


    Sources:
    NCI

  • MELATONIN   MAOB

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9726430


    Sources:
    NCI

  • MELATONIN   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15205854


    Sources:
    NCI

  • MELATONIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16313502


    Sources:
    NCI

  • MELATONIN   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MELATONIN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MELATONIN

    • Version: 01-August-2011

    Alternate Names:
    MELATONIN Primary Drug Name

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: MELATONIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • NCI: MELATONIN

    • Version: 14-September-2017

    Alternate Names:
    C632 NCI drug code

    Drug Info:

    Publications:
    Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.
    Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
    Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.

  • TTD: Melatonin

    • Version: 2020.06.01

    Alternate Names:
    D0AN7B TTD Drug ID

    Drug Info:

    Publications:

  • DTC: MELATONIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL45 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL45

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21