DGIdb - MEMANTINE Drug Record

MEMANTINE chembl:CHEMBL807 Approved

Alternate Names:

MEMANTINE
D-145
DRG-0267
NAMENDA
MEMANTINA
1,3-DIMETHYL-5-ADAMANTANAMINE
1-AMINO-3,5-DIMETHYLADAMANTANE
MEMANTINUM
3,5-DIMETHYL-1-AMINOADAMANTANE
NAMENDA®
3,5-DIMETHYL-1-ADAMANTANAMINE
1,3-DIMETHYLAMINOADAMANTANE
3,5-DIMETHYLTRICYCLO(3.3.1.1(3,7))DECAN-1-AMINE
chemidplus:19982-08-2
pubchem.compound:4054
rxcui:6719
chembl:CHEMBL807
drugbank:01043

Drug Info:

Drug Class	antiparkinson agents
Year of Approval	2003
Drug Indications	for treatment of Alzheimer's disease
FDA Approval	approved
Drug Indications	for treatment of glaucoma
Drug Class	Small Molecule

(2 More Sources)

Publications:

Smothers et al., 2007, Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits., J. Pharmacol. Exp. Ther.
Rogawski et al., 2003, The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease., CNS Drug Rev
Schrattenholz et al., 2006, NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling., Curr Top Med Chem
Chatterton et al., 2002, Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits., Nature
Foster et al., 2006, Glutamate- and GABA-based CNS therapeutics., Curr Opin Pharmacol
Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem
Kotermanski et al., 2009, Memantine binding to a superficial site on NMDA receptors contributes to partial trapping., J. Physiol. (Lond.)
Cacabelos R et al., 1999, The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease., Int J Geriatr Psychiatry
Robinson DM et al., 2006, Memantine: a review of its use in Alzheimer's disease., Drugs
Chen et al., 2005, Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels., J. Pharmacol. Exp. Ther.
Blanpied et al., 1997, Trapping channel block of NMDA-activated responses by amantadine and memantine., J. Neurophysiol.
Maler et al., 2005, Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons., Brain Res.
Bresink et al., 1996, Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells., Br. J. Pharmacol.
Nakazato et al., 2005, Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model., Pharmacology
Kashiwagi et al., 2002, Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore., Mol. Pharmacol.
Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet

MEMANTINE GRIN2A

Interaction Score: 3.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20361801 15901795 14530799 9120573 16009352 8886398

Sources:
DTC TEND
MEMANTINE GRIN3A

Interaction Score: 2.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Namenda

Novel drug target Established target

Trial Name memantine

PMIDs:
17502428 14530799 16719808 11823786 16377242

Sources:
TdgClinicalTrial TEND
MEMANTINE GRIN2B

Interaction Score: 2.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
14530799 15452358 16009352 9120573 11854433

Sources:
TdgClinicalTrial TEND
MEMANTINE GRIN1

Interaction Score: 2.11

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
20361801 19687120 10029935 16906789 14530799

Sources:
DTC TdgClinicalTrial
MEMANTINE NR1I2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23371894

Sources:
PharmGKB

TEND: MEMANTINE
- Version: 01-August-2011
Alternate Names:

MEMANTINE Primary Drug Name

Drug Info:

Year of Approval 2003

Drug Class antiparkinson agents

Publications:
TdgClinicalTrial: MEMANTINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

Drug Indications for treatment of glaucoma

FDA Approval approved

Publications:
DTC: MEMANTINE
- Version: 02-September-2020
Alternate Names:

CHEMBL807 ChEMBL Drug ID

Drug Info:

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem
PharmGKB: memantine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet
TTD: Memantine
- Version: 2020.06.01
Alternate Names:

D01JEU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL807
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Namenda
Novel drug target	Established target
Trial Name	memantine

binder
antagonist (inhibitory)

MEMANTINE Drug Record

MEMANTINE chembl:CHEMBL807 Approved

Alternate Names:

Drug Info:

Publications:

MEMANTINE GRIN2A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 20361801 15901795 14530799 9120573 16009352 8886398

Sources: DTC TEND

MEMANTINE GRIN3A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Namenda Novel drug target Established target Trial Name memantine

PMIDs: 17502428 14530799 16719808 11823786 16377242

Sources: TdgClinicalTrial TEND

MEMANTINE GRIN2B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name memantine Novel drug target Established target Trial Name Namenda

PMIDs: 14530799 15452358 16009352 9120573 11854433

Sources: TdgClinicalTrial TEND

MEMANTINE GRIN1

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Trial Name memantine Novel drug target Established target Trial Name Namenda

PMIDs: 20361801 19687120 10029935 16906789 14530799

Sources: DTC TdgClinicalTrial

MEMANTINE NR1I2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23371894

Sources: PharmGKB

TEND: MEMANTINE

Alternate Names: MEMANTINE Primary Drug Name

Drug Info: Year of Approval 2003 Drug Class antiparkinson agents

Publications:

TdgClinicalTrial: MEMANTINE

Alternate Names:

Drug Info: Drug Class Small Molecule Drug Indications for treatment of glaucoma FDA Approval approved

Publications:

DTC: MEMANTINE

Alternate Names: CHEMBL807 ChEMBL Drug ID

Drug Info:

Publications: Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

PharmGKB: memantine

Alternate Names:

Drug Info:

Publications: Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet

TTD: Memantine

Alternate Names: D01JEU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL807

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
20361801 15901795 14530799 9120573 16009352 8886398

Sources:
DTC TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Namenda

Novel drug target Established target

Trial Name memantine

PMIDs:
17502428 14530799 16719808 11823786 16377242

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
14530799 15452358 16009352 9120573 11854433

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
20361801 19687120 10029935 16906789 14530799

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23371894

Sources:
PharmGKB

Alternate Names:

MEMANTINE Primary Drug Name

Drug Info:

Year of Approval 2003

Drug Class antiparkinson agents

Drug Info:

Drug Class Small Molecule

Drug Indications for treatment of glaucoma

FDA Approval approved

Alternate Names:

CHEMBL807 ChEMBL Drug ID

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

Publications:

Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet

Alternate Names:

D01JEU TTD Drug ID