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MEPERIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MEPERIDINE chembl:CHEMBL607 Approved

    Alternate Names:

    PETHIDINE
    MEPERIDINE
    IDS-NP-001
    PÉTHIDINE
    PETYDYNA
    ISONIPECAÏNE
    MEPADIN
    LYDOL
    PETHIDINUM
    DEMEROL®
    DEMEROL
    PETIDINA
    DOLANTIN
    PETHIDIN
    ALODAN
    pubchem.compound:4058
    rxcui:6754
    drugbank:00454
    chemidplus:57-42-1
    chembl:CHEMBL607

    Drug Info:

    Year of Approval 1942
    Drug Class analgesics, opioid
    FDA Approval 1942
    Drug Class small molecule
    Drug Indications Analgesics, Opioid
    (1 More Sources)

    Publications:

    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Ikeda T et al., 1997, The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine., Ann N Y Acad Sci
    Cruz Pardos P et al., 2000, [Usefulness of meperidine in anesthesiology]., Rev Esp Anestesiol Reanim
    Yasaei R et al., 2020, Meperidine,
    Kurz M et al., 1993, Naloxone, meperidine, and shivering., Anesthesiology
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
  • MEPERIDINE   OPRK1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 9100971 10846914 29261967 8267194


    Sources:
    TdgClinicalTrial TEND

  • MEPERIDINE   CYP2B6

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11470993 17638512


    Sources:
    PharmGKB

  • MEPERIDINE   CYP3A5

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • MEPERIDINE   ADRA2A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TEND: MEPERIDINE

    • Version: 01-August-2011

    Alternate Names:
    MEPERIDINE Primary Drug Name

    Drug Info:
    Drug Class analgesics, opioid
    Year of Approval 1942

    Publications:

  • TdgClinicalTrial: MEPERIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Analgesics, Opioid
    Drug Class small molecule
    FDA Approval 1942

    Publications:

  • PharmGKB: meperidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
    Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics

  • TTD: Meperidine

    • Version: 2020.06.01

    Alternate Names:
    D00UYE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL607

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21