DGIdb - MEPERIDINE Drug Record

MEPERIDINE chembl:CHEMBL607 Approved

Alternate Names:

PETHIDINE
MEPERIDINE
IDS-NP-001
PÉTHIDINE
PETYDYNA
ISONIPECAÏNE
MEPADIN
LYDOL
PETHIDINUM
DEMEROL®
DEMEROL
PETIDINA
DOLANTIN
PETHIDIN
ALODAN
pubchem.compound:4058
rxcui:6754
drugbank:00454
chemidplus:57-42-1
chembl:CHEMBL607

Drug Info:

Year of Approval	1942
Drug Class	analgesics, opioid
FDA Approval	1942
Drug Class	small molecule
Drug Indications	Analgesics, Opioid

(2 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Ikeda T et al., 1997, The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine., Ann N Y Acad Sci
Cruz Pardos P et al., 2000, [Usefulness of meperidine in anesthesiology]., Rev Esp Anestesiol Reanim
Yasaei R et al., 2020, Meperidine,
Kurz M et al., 1993, Naloxone, meperidine, and shivering., Anesthesiology
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Poulain et al., 2001, From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands., J. Med. Chem.
Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

MEPERIDINE OPRK1

Interaction Score: 1.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
17016423 17139284 9100971 10846914 29261967 8267194

Sources:
TdgClinicalTrial TEND GuideToPharmacology
MEPERIDINE CYP2B6

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11470993 17638512

Sources:
PharmGKB
MEPERIDINE CYP3A5

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
MEPERIDINE OPRM1

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11585443

Sources:
GuideToPharmacology
MEPERIDINE OPRD1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
MEPERIDINE ADRA2A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: MEPERIDINE
- Version: 01-August-2011
Alternate Names:

MEPERIDINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1942

Publications:
TdgClinicalTrial: MEPERIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1942

Publications:

PharmGKB: meperidine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics

GuideToPharmacology: 178103795
- Version: 29-September-2020
Alternate Names:

PETHIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Meperidine
- Version: 2020.06.01
Alternate Names:

D00UYE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL607
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Agonist

MEPERIDINE Drug Record

MEPERIDINE chembl:CHEMBL607 Approved

Alternate Names:

Drug Info:

Publications:

MEPERIDINE OPRK1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: 17016423 17139284 9100971 10846914 29261967 8267194

Sources: TdgClinicalTrial TEND GuideToPharmacology

MEPERIDINE CYP2B6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11470993 17638512

Sources: PharmGKB

MEPERIDINE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

MEPERIDINE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 11585443

Sources: GuideToPharmacology

MEPERIDINE OPRD1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

MEPERIDINE ADRA2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: MEPERIDINE

Alternate Names: MEPERIDINE Primary Drug Name

Drug Info: Drug Class analgesics, opioid Year of Approval 1942

Publications:

TdgClinicalTrial: MEPERIDINE

Alternate Names:

Drug Info: Drug Indications Analgesics, Opioid Drug Class small molecule FDA Approval 1942

Publications:

PharmGKB: meperidine

Alternate Names:

Drug Info:

GuideToPharmacology: 178103795

Alternate Names: PETHIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Meperidine

Alternate Names: D00UYE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL607

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
17016423 17139284 9100971 10846914 29261967 8267194

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11470993 17638512

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11585443

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

MEPERIDINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1942

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1942

Alternate Names:

PETHIDINE GuideToPharmacology Ligand Name

Alternate Names:

D00UYE TTD Drug ID