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MEPHOBARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • MEPHOBARBITAL chembl:CHEMBL45029 Approved

    Alternate Names:

    MEBARAL
    ENPHENEMAL
    METHYLPHENOBARBITONE
    MENTA-BAL
    MEPHOBARBITAL
    PROMINAL
    METHYLPHENOBARBITAL
    N-METHYLPHENOBARBITAL
    5-ETHYL-1-METHYL-5-PHENYLBARBITURIC ACID
    1-METHYLPHENOBARBITAL
    5-ETHYL-1-METHYL-5-PHENYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    METILFENOBARBITALE
    MÉTHYLPHÉNOBARBITAL
    METHYLPHENOBARBITALUM
    METILFENOBARBITAL
    5-ETHYL-1-METHYL-5-PHENYL-PYRIMIDINE-2,4,6-TRIONE
    MEPHOBARBITONE
    chemidplus:115-38-8
    pubchem.compound:8271
    rxcui:6758
    chembl:CHEMBL45029
    drugbank:00849

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Indications Anticonvulsants
    Drug Class hypnotics and sedatives
    Drug Class anticonvulsants
    Year of Approval approved before 1982
    (2 More Sources)

    Publications:

    Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Roden et al., 2010, Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex., Neurosci. Lett.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet
  • MEPHOBARBITAL   GRIK2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GRIA2

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   CHRNA7

    Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14579514 10209232 11752352 21194017 11264449 10487207 20692323 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • MEPHOBARBITAL   CHRNA4

    Interaction Score: 0.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16248797 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA6

    Interaction Score: 0.38

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    21194017 10209232 11264449


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA5

    Interaction Score: 0.35

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    21194017 10209232 11264449


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    21194017 10209232 11264449


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    21194017 10209232 11264449


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   GABRA4

    Interaction Score: 0.31

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    21194017 10209232


    Sources:
    TdgClinicalTrial TEND

  • MEPHOBARBITAL   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15499191


    Sources:
    PharmGKB

  • MEPHOBARBITAL   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: METHYLPHENOBARBITAL

    • Version: 01-August-2011

    Alternate Names:
    METHYLPHENOBARBITAL Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class anticonvulsants
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: METHYLPHENOBARBITAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anticonvulsants
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule

    Publications:

  • PharmGKB: methylphenobarbital

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet

  • DTC: MEPHOBARBITAL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL45029 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Methylphenobarbital

    • Version: 2020.06.01

    Alternate Names:
    D08UMH TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL45029

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21