DGIdb - MEPHOBARBITAL Drug Record

MEPHOBARBITAL chembl:CHEMBL45029 Approved

Alternate Names:

MEBARAL
ENPHENEMAL
METHYLPHENOBARBITONE
MENTA-BAL
MEPHOBARBITAL
PROMINAL
METHYLPHENOBARBITAL
N-METHYLPHENOBARBITAL
5-ETHYL-1-METHYL-5-PHENYLBARBITURIC ACID
1-METHYLPHENOBARBITAL
5-ETHYL-1-METHYL-5-PHENYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
METILFENOBARBITALE
MÉTHYLPHÉNOBARBITAL
METHYLPHENOBARBITALUM
METILFENOBARBITAL
5-ETHYL-1-METHYL-5-PHENYL-PYRIMIDINE-2,4,6-TRIONE
MEPHOBARBITONE
chemidplus:115-38-8
pubchem.compound:8271
rxcui:6758
chembl:CHEMBL45029
drugbank:00849

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Anticonvulsants
Drug Class	hypnotics and sedatives
Drug Class	anticonvulsants
Year of Approval	approved before 1982
Drug Categories	anticholinergic agents
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	nicotinic antagonists
Drug Categories	phenobarbital and similars
Drug Categories	psycholeptics

(3 More Sources)

Publications:

Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Roden et al., 2010, Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex., Neurosci. Lett.
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet
Kobayashi K et al., 2004, Key structural features of ligands for activation of human pregnane X receptor., Drug Metab Dispos

MEPHOBARBITAL GRIK2

Interaction Score: 0.99

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL CHRNA4

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GRIA2

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA1

Interaction Score: 0.44

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20692323 14579514 21194017 11264449 11752352 17139284 10209232 17016423 10487207

Sources:
TEND TdgClinicalTrial TTD DrugBank
MEPHOBARBITAL CHRNA7

Interaction Score: 0.4

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA6

Interaction Score: 0.33

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA5

Interaction Score: 0.3

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA2

Interaction Score: 0.29

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA3

Interaction Score: 0.29

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL GABRA4

Interaction Score: 0.28

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 10209232

Sources:
TEND TdgClinicalTrial DrugBank
MEPHOBARBITAL NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
15039302

Sources:
DrugBank
MEPHOBARBITAL CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15499191

Sources:
PharmGKB
MEPHOBARBITAL AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00849

Version: 5.1.7

Alternate Names:

METHYLPHENOBARBITAL DrugBank Drug Name

115-38-8 CAS Number

Mebaral Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticholinergic agents

Publications:

Roden et al., 2010, Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex., Neurosci. Lett.

Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel

Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth

TEND: METHYLPHENOBARBITAL
- Version: 01-August-2011
Alternate Names:

METHYLPHENOBARBITAL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anticonvulsants

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: METHYLPHENOBARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
PharmGKB: methylphenobarbital
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet
DTC: MEPHOBARBITAL
- Version: 02-September-2020
Alternate Names:

CHEMBL45029 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Methylphenobarbital
- Version: 2020.06.01
Alternate Names:

D08UMH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL45029
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

METHYLPHENOBARBITAL	DrugBank Drug Name
115-38-8	CAS Number
Mebaral	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	anticholinergic agents

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

MEPHOBARBITAL Drug Record

MEPHOBARBITAL chembl:CHEMBL45029 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 16248797 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 20692323 14579514 21194017 11264449 11752352 17139284 10209232 17016423 10487207

Sources: TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 16248797 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 21194017 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 21194017 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 21194017 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 21194017 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 21194017 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 15039302

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15499191

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00849

Alternate Names: METHYLPHENOBARBITAL DrugBank Drug Name 115-38-8 CAS Number Mebaral Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories anticholinergic agents

TEND: METHYLPHENOBARBITAL

Alternate Names: METHYLPHENOBARBITAL Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class anticonvulsants Drug Class hypnotics and sedatives

Publications:

TdgClinicalTrial: METHYLPHENOBARBITAL

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Indications Hypnotics and Sedatives Drug Class small molecule

Publications:

PharmGKB: methylphenobarbital

Alternate Names:

Drug Info:

Publications: Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet

DTC: MEPHOBARBITAL

Alternate Names: CHEMBL45029 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Methylphenobarbital

Alternate Names: D08UMH TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20692323 14579514 21194017 11264449 11752352 17139284 10209232 17016423 10487207

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
21194017 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
15039302

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15499191

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METHYLPHENOBARBITAL DrugBank Drug Name

115-38-8 CAS Number

Mebaral Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticholinergic agents

Alternate Names:

METHYLPHENOBARBITAL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anticonvulsants

Drug Class hypnotics and sedatives

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:

Morita J et al., 2004, A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation., Drug Metab Pharmacokinet

Alternate Names:

CHEMBL45029 ChEMBL Drug ID

Alternate Names:

D08UMH TTD Drug ID