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MEPIVACAINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MEPIVACAINE chembl:CHEMBL1087 Approved

    Alternate Names:

    POLOCAINE
    MEPIVACAINE
    CARBOCAINE
    POLOCAINE-MPF
    APF-135

    Drug Info:

    Drug Class anesthetics, local
    Year of Approval approved before 1982
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications anestethic
    (3 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Leffler et al., 2010, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites., Eur. J. Pharmacol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
  • MEPIVACAINE   CYB5R3

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MEPIVACAINE   SCN10A

    Interaction Score: 0.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name APF 112, mepivacaine sustained-release
    Novel drug target Established target

    PMIDs:
    20044988 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • MEPIVACAINE   G6PD

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • MEPIVACAINE   CYP2C9

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MEPIVACAINE   CYP2C19

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MEPIVACAINE   CYP1A2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MEPIVACAINE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: MEPIVACAINE

    • Version: 01-August-2011

    Alternate Names:
    MEPIVACAINE Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class anesthetics, local

    Publications:

  • TdgClinicalTrial: MEPIVACAINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications anestethic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: MEPIVACAINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1087 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Mepivacaine

    • Version: 2020.06.01

    Alternate Names:
    D0WO8W TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1087

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: mepivacaine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Mepivacaine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21