DGIdb - MEPIVACAINE Drug Record

MEPIVACAINE chembl:CHEMBL1087 Approved

Alternate Names:

POLOCAINE
MEPIVACAINE
CARBOCAINE
POLOCAINE-MPF
APF-135

Drug Info:

Drug Class	anesthetics, local
Year of Approval	approved before 1982
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anestethic

(3 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Leffler et al., 2010, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites., Eur. J. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

MEPIVACAINE CYB5R3

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MEPIVACAINE SCN10A

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name APF 112, mepivacaine sustained-release

Novel drug target Established target

PMIDs:
20044988 17016423 17139284

Sources:
TdgClinicalTrial TEND
MEPIVACAINE G6PD

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
MEPIVACAINE CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MEPIVACAINE CYP2C19

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MEPIVACAINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MEPIVACAINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: MEPIVACAINE
- Version: 01-August-2011
Alternate Names:

MEPIVACAINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anesthetics, local

Publications:
TdgClinicalTrial: MEPIVACAINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anestethic

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: MEPIVACAINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1087 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Mepivacaine
- Version: 2020.06.01
Alternate Names:

D0WO8W TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1087
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: mepivacaine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Mepivacaine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	APF 112, mepivacaine sustained-release
Novel drug target	Established target

MEPIVACAINE Drug Record

MEPIVACAINE chembl:CHEMBL1087 Approved

Alternate Names:

Drug Info:

Publications:

MEPIVACAINE CYB5R3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

MEPIVACAINE SCN10A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name APF 112, mepivacaine sustained-release Novel drug target Established target

PMIDs: 20044988 17016423 17139284

Sources: TdgClinicalTrial TEND

MEPIVACAINE G6PD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

MEPIVACAINE CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MEPIVACAINE CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MEPIVACAINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MEPIVACAINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: MEPIVACAINE

Alternate Names: MEPIVACAINE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class anesthetics, local

Publications:

TdgClinicalTrial: MEPIVACAINE

Alternate Names:

Drug Info: Drug Indications anestethic Drug Class Small Molecule FDA Approval approved

Publications:

DTC: MEPIVACAINE

Alternate Names: CHEMBL1087 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Mepivacaine

Alternate Names: D0WO8W TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1087

Alternate Names:

Drug Info:

Publications:

PharmGKB: mepivacaine

Alternate Names:

Drug Info:

Publications:

FDA: Mepivacaine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name APF 112, mepivacaine sustained-release

Novel drug target Established target

PMIDs:
20044988 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

MEPIVACAINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anesthetics, local

Drug Info:

Drug Indications anestethic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1087 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0WO8W TTD Drug ID