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MESORIDAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MESORIDAZINE chembl:CHEMBL1088 Approved

    Alternate Names:

    NC-123
    TPS-23
    LIDANAR
    SERENTIL
    MESORIDAZINE
    MESORIDAZINUM
    SERENTIL®
    THIORIDAZINE-2-SULFOXIDE
    10-(2(1-METHYL-2-PIPERIDYL)ETHYL)-2-(METHYLSULFINYL)PHENOTHIAZINE
    MESORIDAZINA
    2-METHANESULFINYL-10-[2-(1-METHYL-PIPERIDIN-2-YL)-ETHYL]-10H-PHENOTHIAZINE
    10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-2-METHYLSULFINYL PHENOTHIAZINE
    THIORIDAZINE THIOMETHYL SULFOXIDE
    drugbank:00933
    chembl:CHEMBL1088
    chemidplus:5588-33-0
    pubchem.compound:4078
    rxcui:6779

    Drug Info:

    FDA Approval 1970
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    Year of Approval 1970
    Drug Class antipsychotic agents
    (2 More Sources)

    Publications:

    Choi et al., 2004, Synthesis, receptor binding and functional studies of mesoridazine stereoisomers., Bioorg. Med. Chem. Lett.
    Rauser et al., 2001, Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor., J. Pharmacol. Exp. Ther.
    Herrick-Davis et al., 2000, Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors., J. Pharmacol. Exp. Ther.
    Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
  • MESORIDAZINE   CYP2J2

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • MESORIDAZINE   HTR2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15357957 11561066 10991983


    Sources:
    TdgClinicalTrial TEND

  • MESORIDAZINE   DRD2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16135699 15357957 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • MESORIDAZINE   EHMT2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MESORIDAZINE

    • Version: 01-August-2011

    Alternate Names:
    MESORIDAZINE Primary Drug Name

    Drug Info:
    Drug Class antipsychotic agents
    Year of Approval 1970

    Publications:

  • TdgClinicalTrial: MESORIDAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antipsychotic Agents
    Drug Class small molecule
    FDA Approval 1970

    Publications:

  • PharmGKB: mesoridazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

  • TTD: Mesoridazine

    • Version: 2020.06.01

    Alternate Names:
    D04AAN TTD Drug ID

    Drug Info:

    Publications:

  • DTC: MESORIDAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1088 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1088

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21