DGIdb - MESORIDAZINE Drug Record

MESORIDAZINE chembl:CHEMBL1088 Approved

Alternate Names:

NC-123
TPS-23
LIDANAR
SERENTIL
MESORIDAZINE
MESORIDAZINUM
SERENTIL®
THIORIDAZINE-2-SULFOXIDE
10-(2(1-METHYL-2-PIPERIDYL)ETHYL)-2-(METHYLSULFINYL)PHENOTHIAZINE
MESORIDAZINA
2-METHANESULFINYL-10-[2-(1-METHYL-PIPERIDIN-2-YL)-ETHYL]-10H-PHENOTHIAZINE
10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-2-METHYLSULFINYL PHENOTHIAZINE
THIORIDAZINE THIOMETHYL SULFOXIDE
drugbank:00933
chembl:CHEMBL1088
chemidplus:5588-33-0
pubchem.compound:4078
rxcui:6779

Drug Info:

FDA Approval	1970
Drug Class	small molecule
Drug Indications	Antipsychotic Agents
Year of Approval	1970
Drug Class	antipsychotic agents

(2 More Sources)

Publications:

Choi et al., 2004, Synthesis, receptor binding and functional studies of mesoridazine stereoisomers., Bioorg. Med. Chem. Lett.
Rauser et al., 2001, Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor., J. Pharmacol. Exp. Ther.
Herrick-Davis et al., 2000, Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors., J. Pharmacol. Exp. Ther.
Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

MESORIDAZINE CYP2J2

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19923256

Sources:
PharmGKB
MESORIDAZINE HTR2A

Interaction Score: 0.77

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15357957 11561066 10991983

Sources:
TdgClinicalTrial TEND
MESORIDAZINE DRD2

Interaction Score: 0.56

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16135699 15357957 11752352

Sources:
TdgClinicalTrial TEND TTD
MESORIDAZINE EHMT2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MESORIDAZINE
- Version: 01-August-2011
Alternate Names:

MESORIDAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval 1970

Publications:
TdgClinicalTrial: MESORIDAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval 1970

Publications:
PharmGKB: mesoridazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
TTD: Mesoridazine
- Version: 2020.06.01
Alternate Names:

D04AAN TTD Drug ID

Drug Info:

Publications:
DTC: MESORIDAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1088 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1088
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

MESORIDAZINE Drug Record

MESORIDAZINE chembl:CHEMBL1088 Approved

Alternate Names:

Drug Info:

Publications:

MESORIDAZINE CYP2J2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19923256

Sources: PharmGKB

MESORIDAZINE HTR2A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15357957 11561066 10991983

Sources: TdgClinicalTrial TEND

MESORIDAZINE DRD2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16135699 15357957 11752352

Sources: TdgClinicalTrial TEND TTD

MESORIDAZINE EHMT2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: MESORIDAZINE

Alternate Names: MESORIDAZINE Primary Drug Name

Drug Info: Drug Class antipsychotic agents Year of Approval 1970

Publications:

TdgClinicalTrial: MESORIDAZINE

Alternate Names:

Drug Info: Drug Indications Antipsychotic Agents Drug Class small molecule FDA Approval 1970

Publications:

PharmGKB: mesoridazine

Alternate Names:

Drug Info:

Publications: Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

TTD: Mesoridazine

Alternate Names: D04AAN TTD Drug ID

Drug Info:

Publications:

DTC: MESORIDAZINE

Alternate Names: CHEMBL1088 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1088

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
19923256

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15357957 11561066 10991983

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16135699 15357957 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MESORIDAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval 1970

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval 1970

Publications:

Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

Alternate Names:

D04AAN TTD Drug ID

Alternate Names:

CHEMBL1088 ChEMBL Drug ID