DGIdb - MESTRANOL Drug Record

MESTRANOL chembl:CHEMBL1201151 Approved

Alternate Names:

MESTRANOL
EE3-ME
33355
ETHYNYLESTRADIOL 3-METHYL ETHER
3-METHOXY-17ALPHA-ETHYNYLESTRADIOL
(+)-17ALPHA-ETHYNYL-17BETA-HYDROXY-3-METHOXY-1,3,5(10)-OESTRATRIENE
17-ETHYNYL-3-METHOXYOESTRA-1(10),2,4-TRIEN-17BETA-OL
3-METHOXY-19-NORPREGNA-1,3,5(10)-TRIEN-20-YN-17BETA-OL
(+)-17ALPHA-ETHYNYL-17BETA-HYDROXY-3-METHOXY-1,3,5(10)-ESTRATRIENE
rxcui:6782
drugbank:01357
pubchem.compound:6291
chembl:CHEMBL1201151
chemidplus:72-33-3

Drug Info:

Year of Approval	approved before 1982
Drug Class	contraceptives, oral
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Contraceptives, Oral

(3 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Dulos et al., 2010, Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta., Arthritis Res. Ther.
Cleuren et al., 2010, 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α., J. Thromb. Haemost.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Yager et al., 1984, Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol., Cancer Res.
Rudolf et al., 1986, [Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome]., Zentralbl Gynakol
Coezy et al., 1987, Effect of mestranol on cell proliferation and angiotensinogen production in HepG2 cells: relation with the cell cycle and action of tamoxifen., Endocrinology

MESTRANOL TSHB

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2425513

Sources:
NCI
MESTRANOL AGT

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3023023

Sources:
NCI
MESTRANOL GGT1

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6744303

Sources:
NCI
MESTRANOL ESR1

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Estrogen receptor alpha agonist

Trial Name -

PMIDs:
11752352 20497523 20524981

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MESTRANOL CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MESTRANOL CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MESTRANOL CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MESTRANOL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MESTRANOL AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MESTRANOL
- Version: 01-August-2011
Alternate Names:

MESTRANOL Primary Drug Name

Drug Info:

Drug Class contraceptives, oral

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: MESTRANOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Contraceptives, Oral

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
DTC: MESTRANOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1201151 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: MESTRANOL

Version: 14-September-2017

Alternate Names:

C636 NCI drug code

Drug Info:

Publications:

Rudolf et al., 1986, [Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome]., Zentralbl Gynakol

Coezy et al., 1987, Effect of mestranol on cell proliferation and angiotensinogen production in HepG2 cells: relation with the cell cycle and action of tamoxifen., Endocrinology

Yager et al., 1984, Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol., Cancer Res.

TTD: Mestranol
- Version: 2020.06.01
Alternate Names:

D0J1ML TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201151
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201151
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Estrogen receptor alpha agonist
Trial Name	-

MESTRANOL Drug Record

MESTRANOL chembl:CHEMBL1201151 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2425513

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3023023

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6744303

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Estrogen receptor alpha agonist Trial Name -

PMIDs: 11752352 20497523 20524981

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: MESTRANOL

Alternate Names: MESTRANOL Primary Drug Name

Drug Info: Drug Class contraceptives, oral Year of Approval approved before 1982

Publications:

TdgClinicalTrial: MESTRANOL

Alternate Names:

Drug Info: Drug Indications Contraceptives, Oral Drug Class small molecule FDA Approval Approved before 1982

Publications:

DTC: MESTRANOL

Alternate Names: CHEMBL1201151 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

NCI: MESTRANOL

Alternate Names: C636 NCI drug code

Drug Info:

TTD: Mestranol

Alternate Names: D0J1ML TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201151

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201151

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
2425513

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3023023

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6744303

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Estrogen receptor alpha agonist

Trial Name -

PMIDs:
11752352 20497523 20524981

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MESTRANOL Primary Drug Name

Drug Info:

Drug Class contraceptives, oral

Year of Approval approved before 1982

Drug Info:

Drug Indications Contraceptives, Oral

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

CHEMBL1201151 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C636 NCI drug code

Alternate Names:

D0J1ML TTD Drug ID