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MESTRANOL Drug Record

  • Summary
  • Interactions
  • Claims
  • MESTRANOL chembl:CHEMBL1201151 Approved

    Alternate Names:

    MESTRANOL
    EE3-ME
    33355
    ETHYNYLESTRADIOL 3-METHYL ETHER
    3-METHOXY-17ALPHA-ETHYNYLESTRADIOL
    (+)-17ALPHA-ETHYNYL-17BETA-HYDROXY-3-METHOXY-1,3,5(10)-OESTRATRIENE
    17-ETHYNYL-3-METHOXYOESTRA-1(10),2,4-TRIEN-17BETA-OL
    3-METHOXY-19-NORPREGNA-1,3,5(10)-TRIEN-20-YN-17BETA-OL
    (+)-17ALPHA-ETHYNYL-17BETA-HYDROXY-3-METHOXY-1,3,5(10)-ESTRATRIENE
    rxcui:6782
    drugbank:01357
    pubchem.compound:6291
    chembl:CHEMBL1201151
    chemidplus:72-33-3

    Drug Info:

    Year of Approval approved before 1982
    Drug Class contraceptives, oral
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Contraceptives, Oral
    (3 More Sources)

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Dulos et al., 2010, Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta., Arthritis Res. Ther.
    Cleuren et al., 2010, 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α., J. Thromb. Haemost.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Yager et al., 1984, Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol., Cancer Res.
    Rudolf et al., 1986, [Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome]., Zentralbl Gynakol
    Coezy et al., 1987, Effect of mestranol on cell proliferation and angiotensinogen production in HepG2 cells: relation with the cell cycle and action of tamoxifen., Endocrinology
  • MESTRANOL   TSHB

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2425513


    Sources:
    NCI

  • MESTRANOL   AGT

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3023023


    Sources:
    NCI

  • MESTRANOL   GGT1

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6744303


    Sources:
    NCI

  • MESTRANOL   ESR1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor alpha agonist
    Trial Name -

    PMIDs:
    11752352 20497523 20524981


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • MESTRANOL   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MESTRANOL   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MESTRANOL   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MESTRANOL   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MESTRANOL   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MESTRANOL

    • Version: 01-August-2011

    Alternate Names:
    MESTRANOL Primary Drug Name

    Drug Info:
    Drug Class contraceptives, oral
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: MESTRANOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Contraceptives, Oral
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • DTC: MESTRANOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1201151 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • NCI: MESTRANOL

    • Version: 14-September-2017

    Alternate Names:
    C636 NCI drug code

    Drug Info:

    Publications:
    Rudolf et al., 1986, [Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome]., Zentralbl Gynakol
    Coezy et al., 1987, Effect of mestranol on cell proliferation and angiotensinogen production in HepG2 cells: relation with the cell cycle and action of tamoxifen., Endocrinology
    Yager et al., 1984, Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol., Cancer Res.

  • TTD: Mestranol

    • Version: 2020.06.01

    Alternate Names:
    D0J1ML TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201151

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1201151

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21