DGIdb - METARAMINOL Drug Record

METARAMINOL chembl:CHEMBL1201319 Approved

Alternate Names:

METARAMINOL
(-)-ERYTHRO-METARAMINOL
METARAMINOLUM
HYDROXYNOREPHEDRINE
3-HYDROXYPHENYLISOPROPANOLAMINE
M-HYDROXYPROPADRINE
M-HYDROXY NOREPHEDRINE
MÉTARAMINOL
1-(M-HYDROXYPHENYL)-2-AMINO-1-PROPANOL
M-HYDROXYPHENYLPROPANOLAMINE
ARAMINE®
METARAMINOL BITARTRATE
ALPHA-(1-AMINOETHYL)-3-HYDROXYBENZENEMETHANOL
1-METARAMINOL
ALPHA-(M-HYDROXYPHENYL)-BETA-AMINOPROPANOL
METARADRINE
2-AMINO-1-(M-HYDROXYPHENYL)-1-PROPANOL
L-METARAMINOL
pubchem.compound:5906
chemidplus:54-49-9
rxcui:6805
chembl:CHEMBL1201319
drugbank:00610

Drug Info:

Drug Class	antihypotensive agents
Year of Approval	approved before 1982
Drug Class	vasoconstrictor agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Vasoconstrictor Agents
Drug Indications	Antihypotensive Agents

(1 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Tatsuta et al., 1998, Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats., Int. J. Cancer
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

METARAMINOL ADRA1A

Interaction Score: 0.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9663612 17016423 17139284

Sources:
TdgClinicalTrial TEND
METARAMINOL DRD2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METARAMINOL CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METARAMINOL CYP2C19

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METARAMINOL CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METARAMINOL CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METARAMINOL CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: METARAMINOL
- Version: 01-August-2011
Alternate Names:

METARAMINOL Primary Drug Name

Drug Info:

Drug Class vasoconstrictor agents

Year of Approval approved before 1982

Drug Class antihypotensive agents

Publications:
TdgClinicalTrial: METARAMINOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Publications:
DTC: METARAMINOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1201319 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Metaraminol
- Version: 2020.06.01
Alternate Names:

D04EYC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201319
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

METARAMINOL Drug Record

METARAMINOL chembl:CHEMBL1201319 Approved

Alternate Names:

Drug Info:

Publications:

METARAMINOL ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9663612 17016423 17139284

Sources: TdgClinicalTrial TEND

METARAMINOL DRD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

METARAMINOL CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

METARAMINOL CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

METARAMINOL CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

METARAMINOL CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

METARAMINOL CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: METARAMINOL

Alternate Names: METARAMINOL Primary Drug Name

Drug Info: Drug Class vasoconstrictor agents Year of Approval approved before 1982 Drug Class antihypotensive agents

Publications:

TdgClinicalTrial: METARAMINOL

Alternate Names:

Drug Info: Drug Indications Antihypotensive Agents Drug Indications Vasoconstrictor Agents Drug Class small molecule

Publications:

DTC: METARAMINOL

Alternate Names: CHEMBL1201319 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Metaraminol

Alternate Names: D04EYC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201319

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9663612 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

METARAMINOL Primary Drug Name

Drug Info:

Drug Class vasoconstrictor agents

Year of Approval approved before 1982

Drug Class antihypotensive agents

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Alternate Names:

CHEMBL1201319 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D04EYC TTD Drug ID