DGIdb - METHAZOLAMIDE Drug Record

METHAZOLAMIDE chembl:CHEMBL19 Approved

Alternate Names:

VVP-808
L-584601
VVP808
METHAZOLAMIDE
NEPTAZANE

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antiglaucoma agents
Drug Indications	Antihypertensive Agents, Diuretics
Drug Class	antiglaucoma agents
Drug Class	antihypertensive agents, diuretics
Year of Approval	approved before 1982

(4 More Sources)

Publications:

Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Iyer et al., 1999, In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics., J Pharmacokinet Biopharm
Ilies et al., 2004, Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity., Bioorg. Med. Chem.
Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
Tangamornsuksan W et al., 2019, Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis., Pharmacogenomics J
Yang F et al., 2016, HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese., Pharmacogenomics J
Kim SH et al., 2010, HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis., Pharmacogenomics
Shu C et al., 2015, Toxic epidermal necrolysis induced by methazolamide in a Chinese-Korean man carrying HLA-B*59:01., Int J Dermatol
Shirato S et al., 1997, Stevens-Johnson syndrome induced by methazolamide treatment., Arch Ophthalmol

METHAZOLAMIDE CA7

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase VII inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions
METHAZOLAMIDE CA1

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10533697 15110853 14684332 10649985 9336012

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
METHAZOLAMIDE HLA-C

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30242287 25918017 20504258

Sources:
PharmGKB
METHAZOLAMIDE HLA-B

Interaction Score: 1.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30242287 25970075 25918017 20504258 9109770

Sources:
PharmGKB
METHAZOLAMIDE CA4

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions
METHAZOLAMIDE CA2

Interaction Score: 0.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs:
18336310

Sources:
ChemblInteractions
METHAZOLAMIDE INSR

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METHAZOLAMIDE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: METHAZOLAMIDE
- Version: 01-August-2011
Alternate Names:

METHAZOLAMIDE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class antihypertensive agents, diuretics

Drug Class antiglaucoma agents

Publications:
TdgClinicalTrial: METHAZOLAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents, Diuretics

Drug Indications Antiglaucoma agents

Drug Class small molecule

Publications:

PharmGKB: methazolamide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Tangamornsuksan W et al., 2019, Association between HLA-B5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis., Pharmacogenomics J

Kim SH et al., 2010, HLA-B5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis., Pharmacogenomics

Yang F et al., 2016, HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese., Pharmacogenomics J

TTD: Methazolamide
- Version: 2020.06.01
Alternate Names:

D0C2II TTD Drug ID

Drug Info:

Publications:
DTC: METHAZOLAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL19 ChEMBL Drug ID

Drug Info:

Publications:
TTD: VVP-808
- Version: 2020.06.01
Alternate Names:

D07NKZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL19
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL19
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Carbonic anhydrase VII inhibitor
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase I inhibitor
Direct Interaction	yes
Trial Name	-

Mechanism of Interaction	Carbonic anhydrase IV inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Carbonic anhydrase II inhibitor

METHAZOLAMIDE Drug Record

METHAZOLAMIDE chembl:CHEMBL19 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase VII inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes Trial Name -

PMIDs: 10533697 15110853 14684332 10649985 9336012

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30242287 25918017 20504258

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30242287 25970075 25918017 20504258 9109770

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase IV inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs: 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: METHAZOLAMIDE

Alternate Names: METHAZOLAMIDE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class antihypertensive agents, diuretics Drug Class antiglaucoma agents

Publications:

TdgClinicalTrial: METHAZOLAMIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents, Diuretics Drug Indications Antiglaucoma agents Drug Class small molecule

Publications:

PharmGKB: methazolamide

Alternate Names:

Drug Info:

TTD: Methazolamide

Alternate Names: D0C2II TTD Drug ID

Drug Info:

Publications:

DTC: METHAZOLAMIDE

Alternate Names: CHEMBL19 ChEMBL Drug ID

Drug Info:

Publications:

TTD: VVP-808

Alternate Names: D07NKZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL19

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL19

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase VII inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10533697 15110853 14684332 10649985 9336012

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
30242287 25918017 20504258

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30242287 25970075 25918017 20504258 9109770

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METHAZOLAMIDE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class antihypertensive agents, diuretics

Drug Class antiglaucoma agents

Drug Info:

Drug Indications Antihypertensive Agents, Diuretics

Drug Indications Antiglaucoma agents

Drug Class small molecule

Alternate Names:

D0C2II TTD Drug ID

Alternate Names:

CHEMBL19 ChEMBL Drug ID

Alternate Names:

D07NKZ TTD Drug ID