DGIdb - METHIMAZOLE Drug Record

METHIMAZOLE chembl:CHEMBL1515 ApprovedImmunotherapy

Alternate Names:

METHIMAZOLE
TAPAZOLE
NSC-38608
THIAMAZOLE
FAVISTAN
MERCAZOLYL
1-METHYLIMIDAZOLE-2(3H)-THIONE
STRUMAZOL
THACAPZOL
USAF EL-30
DANANTIZOL
THIAMAZOL
THIAMAZOLE®
TIAMAZOL
TAPAZOLE®
THIAMAZOLUM
1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE
pubchem.compound:1349907
chemidplus:60-56-0
rxcui:6835
chembl:CHEMBL1515
drugbank:00763

Drug Info:

Year of Approval	1950
Drug Class	antithyroid agents
FDA Approval	1950
Drug Class	small molecule
Drug Indications	Antithyroid Agents

(4 More Sources)

Publications:

Vámos et al., 1997, [Bone metabolism markers in patients with Basedow-Graves disease]., Orv Hetil
Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.
Leonhardt et al., 1999, Immunoreactive leptin and leptin mRNA expression are increased in rat hypo- but not hyperthyroidism., J. Endocrinol.
Wong et al., 2001, Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus., Mol. Cell. Endocrinol.
Elias et al., 1993, Effect of propylthiouracil and methimazole on serum levels of interleukin-2 receptors in patients with psoriasis., Int. J. Dermatol.
Gessl et al., 1995, Activated naive CD4+ peripheral blood T cells in autoimmune thyroid disease., Thyroid
Balázs, 1991, Increased level of soluble interleukin-2 receptor in sera of patients with Graves' disease., Biomed. Pharmacother.
Elias et al., 1995, Effect of orally administered antithyroid thioureylenes on PCNA and P53 expression in psoriatic lesions., Int. J. Dermatol.
Liu, 1993, Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid mice., Inflammation
Bossowski et al., 2003, Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease., Pediatr. Res.
Ferreira et al., 2003, Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole., Eur. J. Biochem.
Chiovato et al., 1991, The microsomal/peroxidase antigen: modulation of its expression in thyroid cells., Autoimmunity
Manzon et al., 2001, Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus)., J. Exp. Zool.
Sugawara et al., 1999, Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles., Thyroid
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Magnusson et al., 1992, Effect of serum thyrotropin levels on the concentration of messenger RNA for thyroid peroxidase in the rat., Acta Endocrinol.
Burch HB et al., 2018, ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later, Eur J Endocrinol
Seoane et al., 1999, Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure., Brain Res.
Cheung CL et al., 2016, HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis., Clin Pharmacol Ther
Chen PL et al., 2015, Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study., Nat Commun
Bergman et al., 1999, Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb., Toxicol. Appl. Pharmacol.
Bossowski et al., 2004, [Analysis of costimulatory molecules (CD28-CTLA-4/B7) expression on chosen mononuclear cells in adolescents with Graves' disease during methimazole therapy]., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw
Somogyi et al., 1996, Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor., Adverse Drug React Toxicol Rev
Somogyi et al., 1994, [Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factor]., Orv Hetil

METHIMAZOLE TPO

Interaction Score: 12.59

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Mechanism of Interaction Thyroid peroxidase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
METHIMAZOLE CRMP1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11694350

Sources:
NCI
METHIMAZOLE DPYSL3

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11694350

Sources:
NCI
METHIMAZOLE CYP7B1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10053173

Sources:
NCI
METHIMAZOLE IL2RA

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8340196 7647571 1760523

Sources:
NCI
METHIMAZOLE LEP

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10495413

Sources:
NCI
METHIMAZOLE HLA-B

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26599303 26151496

Sources:
PharmGKB
METHIMAZOLE CTLA4

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15504312

Sources:
NCI
METHIMAZOLE FCGR3B

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12761360

Sources:
NCI
METHIMAZOLE BGLAP

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9380378

Sources:
NCI
METHIMAZOLE GFAP

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10375702

Sources:
NCI
METHIMAZOLE CSF2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8836317 7991239

Sources:
NCI
METHIMAZOLE CXCL8

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11453524

Sources:
NCI
METHIMAZOLE HLA-DRB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHIMAZOLE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8491516

Sources:
NCI
METHIMAZOLE JUN

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHIMAZOLE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7790147

Sources:
NCI
METHIMAZOLE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: METHIMAZOLE
- Version: 01-August-2011
Alternate Names:

METHIMAZOLE Primary Drug Name

Drug Info:

Drug Class antithyroid agents

Year of Approval 1950

Publications:
TdgClinicalTrial: METHIMAZOLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antithyroid Agents

Drug Class small molecule

FDA Approval 1950

Publications:

NCI: METHIMAZOLE

Version: 14-September-2017

Alternate Names:

C641 NCI drug code

Drug Info:

Publications:

Vámos et al., 1997, [Bone metabolism markers in patients with Basedow-Graves disease]., Orv Hetil

Bossowski et al., 2001, Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter., J. Pediatr. Endocrinol. Metab.

Leonhardt et al., 1999, Immunoreactive leptin and leptin mRNA expression are increased in rat hypo- but not hyperthyroidism., J. Endocrinol.

PharmGKB: methimazole

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Cheung CL et al., 2016, HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis., Clin Pharmacol Ther

Chen PL et al., 2015, Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study., Nat Commun

TTD: Methimazole
- Version: 2020.06.01
Alternate Names:

D0S4BR TTD Drug ID

Drug Info:

Publications:
DTC: METHIMAZOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL1515 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1515
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1515
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thyroid peroxidase inhibitor
Direct Interaction	yes
Trial Name	-

inhibitor (inhibitory)
substrate

METHIMAZOLE Drug Record

METHIMAZOLE chembl:CHEMBL1515 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info: Mechanism of Interaction Thyroid peroxidase inhibitor Direct Interaction yes Trial Name -

PMIDs: 12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11694350

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11694350

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10053173

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8340196 7647571 1760523

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10495413

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26599303 26151496

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15504312

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12761360

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9380378

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10375702

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8836317 7991239

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11453524

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8491516

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7790147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: METHIMAZOLE

Alternate Names: METHIMAZOLE Primary Drug Name

Drug Info: Drug Class antithyroid agents Year of Approval 1950

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Mechanism of Interaction Thyroid peroxidase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
11694350

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11694350

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10053173

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8340196 7647571 1760523

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10495413

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26599303 26151496

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15504312

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12761360

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9380378

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10375702

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8836317 7991239

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11453524

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8491516

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7790147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METHIMAZOLE Primary Drug Name

Drug Info:

Drug Class antithyroid agents

Year of Approval 1950

Drug Info:

Drug Indications Antithyroid Agents

Drug Class small molecule

FDA Approval 1950

Alternate Names:

C641 NCI drug code

Alternate Names:

D0S4BR TTD Drug ID

Alternate Names:

CHEMBL1515 ChEMBL Drug ID