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METHYLPREDNISOLONE Drug Record

  • Summary
  • Interactions
  • Claims
  • METHYLPREDNISOLONE chembl:CHEMBL650 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    J3.872E
    U-67590A
    MEDROL
    MEDRONE
    METHYLPREDNISOLONE
    NSC-19987
    (6ALPHA,11BETA)-11,17,21-TRIHYDROXY-6-METHYLPREGNA-1,4-DIENE-3,20-DIONE
    METHYLPREDNISOLON
    (6Α,11Β)-11,17,21-TRIHYDROXY-6-METHYLPREGNA-1,4-DIENE-3,20-DIONE
    6ALPHA-METHYL-11BETA,17ALPHA,21-TRIOL-1,4-PREGNADIENE-3,20-DIONE
    MEDRATE
    SOLOMET
    MEDROL®
    DELTA(1)-6ALPHA-METHYLHYDROCORTISONE
    URBASON
    1-DEHYDRO-6Α-METHYLHYDROCORTISONE
    SOLU-MEDROL
    1-DEHYDRO-6ALPHA-METHYLHYDROCORTISONE
    METILPREDNISOLONA
    METHYLPREDNISOLONUM
    chembl:CHEMBL650
    chemidplus:83-43-2
    rxcui:6902
    pubchem.compound:6741
    drugbank:00959

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Glucocorticoids
    Drug Indications Anti-Inflammatory Agents
    Year of Approval approved before 1982
    Drug Class glucocorticoids
    Drug Class anti-inflammatory agents
    (3 More Sources)

    Publications:

    Serres et al., 1994, Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes., Arch. Dermatol. Res.
    Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
    Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku
    Owen et al., 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438., Mol. Cell. Endocrinol.
    Quesnell et al., 2007, Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium., Am. J. Physiol., Cell Physiol.
    Juruena et al., 2006, Different responses to dexamethasone and prednisolone in the same depressed patients., Psychopharmacology (Berl.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Boivin et al., 2007, Mechanism of glucocorticoid regulation of the intestinal tight junction barrier., Am. J. Physiol. Gastrointest. Liver Physiol.
    Kim et al., 2004, Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury., J. Korean Med. Sci.
    Mantzavinos et al., 1996, Serum markers of immune activation in women undergoing in-vitro fertilization and embryo transfer., Hum. Reprod.
    Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
    Michałowska-Wender et al., Effect of methylprednisolone treatment on expression of sPECAM-1 and CXCL10 chemokine in serum of MS patients., Pharmacol Rep
    Hallsworth et al., 1992, Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor-1 and interleukin-5 enhanced in vitro survival of human eosinophils., Immunology
    Taniguchi et al., 1999, Activation of lymphocytes and increased interleukin-5 levels in bronchoalveolar lavage fluid in acute eosinophilic pneumonia., Eur. Respir. J.
    Morris et al., 1997, Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth., Biochem. Mol. Med.
    Adişen et al., 2006, The effects of calcipotriol and methylprednisolone aseponate on bcl-2, p53 and ki-67 expression in psoriasis., J Eur Acad Dermatol Venereol
    Emir et al., 2005, Beneficial effect of methylprednisolone on cardiac myocytes in a rat model of severe brain injury., Tohoku J. Exp. Med.
    Boylan et al., 1999, CD80 (B7-1) and CD86 (B7-2) expression in multiple sclerosis patients: clinical subtype specific variation in peripheral monocytes and B cells and lack of modulation by high dose methylprednisolone., J. Neurol. Sci.
  • METHYLPREDNISOLONE   IL5

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1551701 10836352


    Sources:
    NCI

  • METHYLPREDNISOLONE   CD80

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10521545


    Sources:
    NCI

  • METHYLPREDNISOLONE   CXCL10

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17220550


    Sources:
    NCI

  • METHYLPREDNISOLONE   IFNG

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9396353


    Sources:
    NCI

  • METHYLPREDNISOLONE   ITGB2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8976974


    Sources:
    NCI

  • METHYLPREDNISOLONE   ANXA1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8060156


    Sources:
    TEND

  • METHYLPREDNISOLONE   BCL2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16141680 16684279


    Sources:
    NCI

  • METHYLPREDNISOLONE   IL2RA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8981122


    Sources:
    NCI

  • METHYLPREDNISOLONE   NR3C1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    17182172 17251323 17016711 11752352 17068119


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • METHYLPREDNISOLONE   MYC

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9169090


    Sources:
    NCI

  • METHYLPREDNISOLONE   BDNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14966352


    Sources:
    NCI

  • METHYLPREDNISOLONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14583680


    Sources:
    PharmGKB

  • METHYLPREDNISOLONE   TP53

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16684279


    Sources:
    NCI

  • METHYLPREDNISOLONE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHYLPREDNISOLONE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: METHYLPREDNISOLONE

    • Version: 01-August-2011

    Alternate Names:
    METHYLPREDNISOLONE Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents
    Drug Class glucocorticoids
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: METHYLPREDNISOLONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Inflammatory Agents
    Drug Indications Glucocorticoids
    Drug Class small molecule

    Publications:

  • NCI: METHYLPREDNISOLONE

    • Version: 14-September-2017

    Alternate Names:
    C647 NCI drug code

    Drug Info:

    Publications:
    Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku
    Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
    Mantzavinos et al., 1996, Serum markers of immune activation in women undergoing in-vitro fertilization and embryo transfer., Hum. Reprod.

  • PharmGKB: methylprednisolone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics

  • DTC: METHYLPREDNISOLONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL650 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL650

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL650

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21