DGIdb - METHYLTESTOSTERONE Drug Record

METHYLTESTOSTERONE chembl:CHEMBL1395 ApprovedAntineoplastic

Alternate Names:

17-METHYLTESTOSTERONE
ANDROID 25
ORETON
U-2842
RU 24400
L-589372
NSC-9701
NSC-139965
PLEX HORMONE
ANDROID 10
TESTRED
L 589.372
METHITEST
RU-24400
ANDROID 5
METHYLTESTOSTERONE
PERANDREN
TESTOVIS
METHYLTESTOSTERONE CIII
ORETON METHYL
METANDREN
CDB-110
POTENSAN FTE
L-589.372
VIRILON
17-BETA-HYDROXY-17-METHYLANDROST-4-EN-3-ONE
17Α-METHYL-Δ4-ANDROSTEN-17Β-OL-3-ONE
17BETA-HYDROXY-17-METHYLANDROST-4-EN-3-ONE
17ALPHA-METHYLTESTOSTERONE
17ALPHA-METHYL-DELTA(4)-ANDROSTEN-17BETA-OL-3-ONE
4-ANDROSTENE-17ALPHA-METHYL-17BETA-OL-3-ONE
17Α-METHYLTESTOSTERONE
METILTESTOSTERONA
17ALPHA-METHYL-3-OXO-4-ANDROSTEN-17BETA-OL
17(ALPHA)-METHYL-DELTA(4)-ANDROSTEN-17(BETA)-OL-3-ONE
METHYLTESTOSTERONUM
drugbank:06710
chemidplus:58-18-4
rxcui:6904
chembl:CHEMBL1395
pubchem.compound:6010

Drug Info:

FDA Approval	approved
Drug Class	Small molecule
Drug Indications	for treatment of dysfunctional libido in women

(2 More Sources)

Publications:

Small et al., 2006, The case for secondary hormonal therapies in the chemotherapy age., J. Urol.
Maudsley et al., 2006, Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5., Neuroendocrinology
Petraki et al., 2007, Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma., Histol. Histopathol.
Omwancha et al., 2006, Selective androgen receptor modulators: in pursuit of tissue-selective androgens., Curr Opin Investig Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lapauw et al., 2007, Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?, Eur. J. Endocrinol.
Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue
Huang R et al., 2014, Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway., Sci Rep

METHYLTESTOSTERONE NOS1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15934456

Sources:
NCI

METHYLTESTOSTERONE AR

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name methyltestosterone

Novel drug target Established target

Details of the Assay for Interaction 22Rv1 human prostate cells transfected with hAR and luciferase reporter plasmid driven by the androgen response element.

PMIDs:
17084172 17202804 17128417 17086931 11752352 17322500

Sources:
DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology

METHYLTESTOSTERONE RORC

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLTESTOSTERONE ESR1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25012808

Sources:
DTC
METHYLTESTOSTERONE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: METHYLTESTOSTERONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of dysfunctional libido in women

Drug Class Small molecule

FDA Approval approved

Publications:
NCI: METHYLTESTOSTERONE
- Version: 14-September-2017
Alternate Names:

C648 NCI drug code

Drug Info:

Publications:

Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue
DTC: METHYLTESTOSTERONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1395 ChEMBL Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103527
- Version: 29-September-2020
Alternate Names:

METHYLTESTOSTERONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1395
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1395
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	methyltestosterone
Novel drug target	Established target
Details of the Assay for Interaction	22Rv1 human prostate cells transfected with hAR and luciferase reporter plasmid driven by the androgen response element.

METHYLTESTOSTERONE Drug Record

METHYLTESTOSTERONE chembl:CHEMBL1395 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

METHYLTESTOSTERONE NOS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15934456

Sources: NCI

METHYLTESTOSTERONE AR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name methyltestosterone Novel drug target Established target Details of the Assay for Interaction 22Rv1 human prostate cells transfected with hAR and luciferase reporter plasmid driven by the androgen response element.

PMIDs: 17084172 17202804 17128417 17086931 11752352 17322500

Sources: DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology

METHYLTESTOSTERONE RORC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

METHYLTESTOSTERONE ESR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25012808

Sources: DTC

METHYLTESTOSTERONE NR3C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: METHYLTESTOSTERONE

Alternate Names:

Drug Info: Drug Indications for treatment of dysfunctional libido in women Drug Class Small molecule FDA Approval approved

Publications:

NCI: METHYLTESTOSTERONE

Alternate Names: C648 NCI drug code

Drug Info:

Publications: Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue

DTC: METHYLTESTOSTERONE

Alternate Names: CHEMBL1395 ChEMBL Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178103527

Alternate Names: METHYLTESTOSTERONE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1395

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1395

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15934456

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name methyltestosterone

Novel drug target Established target

Details of the Assay for Interaction 22Rv1 human prostate cells transfected with hAR and luciferase reporter plasmid driven by the androgen response element.

PMIDs:
17084172 17202804 17128417 17086931 11752352 17322500

Sources:
DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25012808

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications for treatment of dysfunctional libido in women

Drug Class Small molecule

FDA Approval approved

Alternate Names:

C648 NCI drug code

Publications:

Ren et al., 2005, [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]., Zhonghua Nan Ke Xue

Alternate Names:

CHEMBL1395 ChEMBL Drug ID

Alternate Names:

METHYLTESTOSTERONE GuideToPharmacology Ligand Name