• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

METOCLOPRAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • METOCLOPRAMIDE chembl:CHEMBL86 Approved

    Alternate Names:

    CLOPRA-"YELLOW"
    CLOPRA
    REGLAN
    MAXOLON
    METOCLOPRAMIDE
    4-AMINO-5-CHLORO-N-(2-DIETHYLAMINOETHYL)-2-METHOXY-BENZAMIDE
    4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-2-METHOXYBENZAMIDE
    2-METHOXY-5-CHLOROPROCAINAMIDE
    METOCLOPRAMIDA
    4-AMINO-5-CHLORO-2-METHOXY-N-(Β-DIETHYLAMINOETHYL)BENZAMIDE
    4-AZANYL-5-CHLORANYL-N-(2-DIETHYLAMINOETHYL)-2-METHOXY-BENZAMIDE
    METOCHLOPRAMIDE
    METOCLOPRAMIDUM
    4-AMINO-5-CHLORO-2-METHOXY-N-(BETA-DIETHYLAMINOETHYL)BENZAMIDE
    4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-O-ANISAMIDE
    2-METHOXY-4-AMINO-5-CHLORO-N,N-(DIMETHYLAMINOETHYL)BENZAMIDE
    REGLAN®
    4-AMINO-5-CHLORO-N-(2-DIETHYLAMINOETHYL)-2-METHOXYBENZAMIDE
    METOCLOPRAMIDE HYDROCHLORIDE
    METHOCHLOPRAMIDE
    METACLOPROMIDE
    rxcui:6915
    chemidplus:364-62-5
    chembl:CHEMBL86
    drugbank:01233
    pubchem.compound:4168

    Drug Info:

    Year of Approval approved before 1982
    Drug Class antiemetics
    Drug Indications antimigraine agent
    Drug Indications antiemetic
    Drug Indications motilitant,for treatment of gastroesophageal reflux disease
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of diabetic gastroparesis
    (3 More Sources)

    Publications:

    Dahlöf et al., 1998, Pathophysiology and pharmacology of migraine. Is there a place for antiemetics in future treatment strategies?, Cephalalgia
    Hammer, Gastroesophageal reflux and prokinetic agents., Neonatal Netw
    Chemnitius et al., Indirect parasympathomimetic activity of metoclopramide: reversible inhibition of cholinesterases from human central nervous system and blood., Pharmacol. Res.
    See et al., 1996, Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats., Neuroscience
    Kishibayashi et al., 1995, Stimulating effects of KW-5092, a novel gastroprokinetic agent, on the gastric emptying, small intestinal propulsion and colonic propulsion in rats., Jpn. J. Pharmacol.
    Harrold et al., 1993, The interaction of ammonium, sulfonium, and sulfide analogues of metoclopramide with the dopamine D2 receptor., J. Med. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Bartolini A et al., 2011, Analgesic and antineuropathic drugs acting through central cholinergic mechanisms., Recent Pat CNS Drug Discov
    Burger et al., 2006, Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers., J Vet Med A Physiol Pathol Clin Med
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Lee A et al., 2010, Metoclopramide in the treatment of diabetic gastroparesis., Expert Rev Endocrinol Metab
    Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica
    Desta et al., 2002, The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6., Drug Metab. Dispos.
    Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil
    Wu et al., 1995, Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma., J. Clin. Endocrinol. Metab.
    Akiyama et al., 2005, Successful treatment of Diamond-Blackfan anemia with metoclopramide., Am. J. Hematol.
  • METOCLOPRAMIDE   CYP11B2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7883831


    Sources:
    NCI

  • METOCLOPRAMIDE   LOH19CR1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15795909


    Sources:
    NCI

  • METOCLOPRAMIDE   CYB5R4

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CYB5R1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CYB5R2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CYB5R3

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11418378


    Sources:
    PharmGKB

  • METOCLOPRAMIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 100
    Trial Name metoclopramide,Emitasol, Pramidin
    Trial Name metoclopramide HCl,Metzoliv ODT

    PMIDs:
    15835479 16466463 17016423 17139284 21278804


    Sources:
    TdgClinicalTrial

  • METOCLOPRAMIDE   DRD2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name MT 100
    Trial Name metoclopramide,Emitasol, Pramidin
    Trial Name metoclopramide HCl,Metzoliv ODT

    PMIDs:
    9876882 15835479 8981558 8730709 7745844 8230103 11752352 21585331


    Sources:
    TdgClinicalTrial TEND TTD

  • METOCLOPRAMIDE   IL2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8191163


    Sources:
    NCI

  • METOCLOPRAMIDE   G6PD

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • METOCLOPRAMIDE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11854155


    Sources:
    NCI

  • METOCLOPRAMIDE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • TEND: METOCLOPRAMIDE

    • Version: 01-August-2011

    Alternate Names:
    METOCLOPRAMIDE Primary Drug Name

    Drug Info:
    Drug Class antiemetics
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: METOCLOPRAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of diabetic gastroparesis
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: METOCLOPRAMIDE

    • Version: 14-September-2017

    Alternate Names:
    C649 NCI drug code

    Drug Info:

    Publications:
    Akiyama et al., 2005, Successful treatment of Diamond-Blackfan anemia with metoclopramide., Am. J. Hematol.
    Desta et al., 2002, The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6., Drug Metab. Dispos.
    Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil

  • PharmGKB: metoclopramide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica

  • TTD: Metoclopramide

    • Version: 2020.06.01

    Alternate Names:
    D08VYV TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL86

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Metoclopramide

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21