DGIdb - METOCLOPRAMIDE Drug Record

METOCLOPRAMIDE chembl:CHEMBL86 Approved

Alternate Names:

CLOPRA-"YELLOW"
CLOPRA
REGLAN
MAXOLON
METOCLOPRAMIDE
4-AMINO-5-CHLORO-N-(2-DIETHYLAMINOETHYL)-2-METHOXY-BENZAMIDE
4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-2-METHOXYBENZAMIDE
2-METHOXY-5-CHLOROPROCAINAMIDE
METOCLOPRAMIDA
4-AMINO-5-CHLORO-2-METHOXY-N-(Β-DIETHYLAMINOETHYL)BENZAMIDE
4-AZANYL-5-CHLORANYL-N-(2-DIETHYLAMINOETHYL)-2-METHOXY-BENZAMIDE
METOCHLOPRAMIDE
METOCLOPRAMIDUM
4-AMINO-5-CHLORO-2-METHOXY-N-(BETA-DIETHYLAMINOETHYL)BENZAMIDE
4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-O-ANISAMIDE
2-METHOXY-4-AMINO-5-CHLORO-N,N-(DIMETHYLAMINOETHYL)BENZAMIDE
REGLAN®
4-AMINO-5-CHLORO-N-(2-DIETHYLAMINOETHYL)-2-METHOXYBENZAMIDE
METOCLOPRAMIDE HYDROCHLORIDE
METHOCHLOPRAMIDE
METACLOPROMIDE
rxcui:6915
chemidplus:364-62-5
chembl:CHEMBL86
drugbank:01233
pubchem.compound:4168

Drug Info:

Year of Approval	approved before 1982
Drug Class	antiemetics
Drug Indications	antimigraine agent
Drug Indications	antiemetic
Drug Indications	motilitant,for treatment of gastroesophageal reflux disease
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of diabetic gastroparesis

(3 More Sources)

Publications:

Dahlöf et al., 1998, Pathophysiology and pharmacology of migraine. Is there a place for antiemetics in future treatment strategies?, Cephalalgia
Hammer, Gastroesophageal reflux and prokinetic agents., Neonatal Netw
Chemnitius et al., Indirect parasympathomimetic activity of metoclopramide: reversible inhibition of cholinesterases from human central nervous system and blood., Pharmacol. Res.
See et al., 1996, Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats., Neuroscience
Kishibayashi et al., 1995, Stimulating effects of KW-5092, a novel gastroprokinetic agent, on the gastric emptying, small intestinal propulsion and colonic propulsion in rats., Jpn. J. Pharmacol.
Harrold et al., 1993, The interaction of ammonium, sulfonium, and sulfide analogues of metoclopramide with the dopamine D2 receptor., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Bartolini A et al., 2011, Analgesic and antineuropathic drugs acting through central cholinergic mechanisms., Recent Pat CNS Drug Discov
Burger et al., 2006, Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers., J Vet Med A Physiol Pathol Clin Med
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lee A et al., 2010, Metoclopramide in the treatment of diabetic gastroparesis., Expert Rev Endocrinol Metab
Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica
Desta et al., 2002, The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6., Drug Metab. Dispos.
Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil
Wu et al., 1995, Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma., J. Clin. Endocrinol. Metab.
Akiyama et al., 2005, Successful treatment of Diamond-Blackfan anemia with metoclopramide., Am. J. Hematol.

METOCLOPRAMIDE CYP11B2

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7883831

Sources:
NCI
METOCLOPRAMIDE LOH19CR1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15795909

Sources:
NCI
METOCLOPRAMIDE CYB5R4

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METOCLOPRAMIDE CYB5R1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METOCLOPRAMIDE CYB5R2

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METOCLOPRAMIDE CYB5R3

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11418378

Sources:
PharmGKB
METOCLOPRAMIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 100

Trial Name metoclopramide,Emitasol, Pramidin

Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs:
15835479 16466463 17016423 17139284 21278804

Sources:
TdgClinicalTrial
METOCLOPRAMIDE DRD2

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name MT 100

Trial Name metoclopramide,Emitasol, Pramidin

Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs:
9876882 15835479 8981558 8730709 7745844 8230103 11752352 21585331

Sources:
TdgClinicalTrial TEND TTD
METOCLOPRAMIDE IL2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8191163

Sources:
NCI
METOCLOPRAMIDE G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
METOCLOPRAMIDE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11854155

Sources:
NCI
METOCLOPRAMIDE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: METOCLOPRAMIDE
- Version: 01-August-2011
Alternate Names:

METOCLOPRAMIDE Primary Drug Name

Drug Info:

Drug Class antiemetics

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: METOCLOPRAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of diabetic gastroparesis

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: METOCLOPRAMIDE

Version: 14-September-2017

Alternate Names:

C649 NCI drug code

Drug Info:

Publications:

Akiyama et al., 2005, Successful treatment of Diamond-Blackfan anemia with metoclopramide., Am. J. Hematol.

Desta et al., 2002, The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6., Drug Metab. Dispos.

Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil

PharmGKB: metoclopramide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica

TTD: Metoclopramide
- Version: 2020.06.01
Alternate Names:

D08VYV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL86
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Metoclopramide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	MT 100
Trial Name	metoclopramide,Emitasol, Pramidin
Trial Name	metoclopramide HCl,Metzoliv ODT

METOCLOPRAMIDE Drug Record

METOCLOPRAMIDE chembl:CHEMBL86 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7883831

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15795909

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11418378

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MT 100 Trial Name metoclopramide,Emitasol, Pramidin Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs: 15835479 16466463 17016423 17139284 21278804

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name MT 100 Trial Name metoclopramide,Emitasol, Pramidin Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs: 9876882 15835479 8981558 8730709 7745844 8230103 11752352 21585331

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8191163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11854155

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: METOCLOPRAMIDE

Alternate Names: METOCLOPRAMIDE Primary Drug Name

Drug Info: Drug Class antiemetics Year of Approval approved before 1982

Publications:

TdgClinicalTrial: METOCLOPRAMIDE

Alternate Names:

Drug Info: Drug Indications for treatment of diabetic gastroparesis Drug Class Small Molecule FDA Approval approved

Publications:

NCI: METOCLOPRAMIDE

Alternate Names: C649 NCI drug code

Drug Info:

PharmGKB: metoclopramide

Alternate Names:

Drug Info:

Publications: Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica

TTD: Metoclopramide

Alternate Names: D08VYV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL86

Alternate Names:

Drug Info:

Publications:

FDA: Metoclopramide

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
7883831

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15795909

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11418378

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 100

Trial Name metoclopramide,Emitasol, Pramidin

Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs:
15835479 16466463 17016423 17139284 21278804

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name MT 100

Trial Name metoclopramide,Emitasol, Pramidin

Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs:
9876882 15835479 8981558 8730709 7745844 8230103 11752352 21585331

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
8191163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
11854155

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

METOCLOPRAMIDE Primary Drug Name

Drug Info:

Drug Class antiemetics

Year of Approval approved before 1982

Drug Info:

Drug Indications for treatment of diabetic gastroparesis

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C649 NCI drug code

Publications:

Karadsheh NS et al., 2001, Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment., Haematologica

Alternate Names:

D08VYV TTD Drug ID