DGIdb - MIANSERIN Drug Record

MIANSERIN chembl:CHEMBL6437 Approved

Alternate Names:

MIANSERIN
J16.389I
NORVAL®
(+-)-ATHYMIL
1,2,3,4,10,14B-HEXAHYDRO-2-METHYLDIBENZO(C,F)PYRAZINO(1,2-A)AZEPINE
MIANSERINE
MIANSERYNA
MIANSERINA
MIANSERINUM
ORG GB 94
drugbank:06148
pubchem.compound:4184
chemidplus:24219-97-4
rxcui:6929
chembl:CHEMBL6437

Drug Info:

Year of Approval	not approved by the fda
Drug Class	antidepressive agents, second-generation
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Second-Generation

(2 More Sources)

Publications:

Dekeyne et al., 2006, Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin., Neuropharmacology
Grinshpoon et al., 2000, Beneficial effect of the addition of the 5-HT 2A/2C and alpha2 antagonist mianserin to ongoing haloperidol treatment in drug-resistant chronically hospitalized schizophrenic patients., Eur. Psychiatry
Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature
Nowak et al., 1983, Interaction between mianserin, an antidepressant drug, and central H1- and H2-histamine-receptors: in vitro and in vivo studies and radioreceptor assay., Neuropharmacology
Csaba et al., 2003, Prolonged effect of the tricyclic antidepressant, mianserin on the serotonin and histamine content of young rats' white blood cells and mast cells. A case of late-imprinting., Pharmacol. Res.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Mihara K et al., 1997, The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients., J Clin Psychopharmacol
Dahl ML et al., 1994, Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism., Clin Pharmacol Ther
Tacke U et al., 1992, Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations., J Clin Psychopharmacol
Kawanishi C et al., 2004, Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study., Eur J Clin Pharmacol

MIANSERIN HTR4

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18033297

Sources:
DTC
MIANSERIN HSPA5

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIANSERIN HTR2C

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11004734

Sources:
TdgClinicalTrial TEND
MIANSERIN HTR3A

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18033297

Sources:
DTC
MIANSERIN ADRA2A

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16814817

Sources:
TdgClinicalTrial TEND
MIANSERIN HRH1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6302549 11004734 12967590

Sources:
TdgClinicalTrial TEND
MIANSERIN HTR2A

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11004734

Sources:
TdgClinicalTrial TEND
MIANSERIN CYP2D6

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9408809 8062494 1527229 14652703

Sources:
PharmGKB
MIANSERIN DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIANSERIN CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: MIANSERIN
- Version: 01-August-2011
Alternate Names:

MIANSERIN Primary Drug Name

Drug Info:

Drug Class antidepressive agents, second-generation

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: MIANSERIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
DTC: MIANSERIN
- Version: 02-September-2020
Alternate Names:

CHEMBL6437 ChEMBL Drug ID

Drug Info:

Publications:

Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature

PharmGKB: mianserin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Kawanishi C et al., 2004, Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study., Eur J Clin Pharmacol

Tacke U et al., 1992, Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations., J Clin Psychopharmacol

TTD: Mianserin
- Version: 2020.06.01
Alternate Names:

D0R6RO TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL6437
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

MIANSERIN Drug Record

MIANSERIN chembl:CHEMBL6437 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18033297

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11004734

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18033297

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16814817

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6302549 11004734 12967590

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11004734

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9408809 8062494 1527229 14652703

Sources: PharmGKB

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: MIANSERIN

Alternate Names: MIANSERIN Primary Drug Name

Drug Info: Drug Class antidepressive agents, second-generation Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: MIANSERIN

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Second-Generation Drug Class small molecule FDA Approval not approved by the FDA

Publications:

DTC: MIANSERIN

Alternate Names: CHEMBL6437 ChEMBL Drug ID

Drug Info:

Publications: Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature

PharmGKB: mianserin

Alternate Names:

Drug Info:

TTD: Mianserin

Alternate Names: D0R6RO TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL6437

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18033297

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11004734

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
18033297

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16814817

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6302549 11004734 12967590

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11004734

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
9408809 8062494 1527229 14652703

Sources:
PharmGKB

Interaction Types & Directionality:

binder

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

MIANSERIN Primary Drug Name

Drug Info:

Drug Class antidepressive agents, second-generation

Year of Approval not approved by the fda

Drug Info:

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

CHEMBL6437 ChEMBL Drug ID

Publications:

Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature

Alternate Names:

D0R6RO TTD Drug ID