DGIdb - MIDAZOLAM Drug Record

MIDAZOLAM chembl:CHEMBL655 Approved

Alternate Names:

USL261
NAYZILAM
MIDAZOLAM
MIDAZOLAM CIV
USL-261
DORMICUM®
VERSED®
BUCCOLAM
DORMICUM
MIDAZOLAMUM
rxcui:6960
chembl:CHEMBL655
drugbank:00683
pubchem.compound:4192
chemidplus:59467-70-8

Drug Info:

Drug Class	hypnotics and sedatives
Drug Class	adjuvants, anesthesia
Year of Approval	1985
FDA Approval	1985
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Adjuvants, Anesthesia

(3 More Sources)

Publications:

Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology
Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol
Elens L et al., 2013, Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin., Pharmacogenet Genomics
Oneda B et al., 2009, The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test., Pharmacogenet Genomics
Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
Galley et al., 1998, The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes., Anesth. Analg.
Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Zhou X et al., 2018, Effect of breviscapine on CYP3A metabolic activity in healthy volunteers., Eur J Clin Pharmacol
Vyhlidal CA et al., 2015, Variability in Expression of CYP3A5 in Human Fetal Liver., Drug Metab Dispos
Seng KY et al., 2014, CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients., J Clin Pharmacol
Elens L et al., 2013, CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin., Pharmacogenomics
Lu et al., 2006, General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain., Apoptosis
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
de Jonge H et al., 2015, Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit., Br J Clin Pharmacol
de Jonge H et al., 2015, The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients., Pharmacogenomics J
Maekawa K et al., 2009, Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine., Xenobiotica
Hohmann N et al., 2015, Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans., Br J Clin Pharmacol
Sippel et al., 2004, Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trial., Surgery

MIDAZOLAM BRDT

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM POR

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23324807 19801957

Sources:
PharmGKB
MIDAZOLAM BRD3

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM BRD2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM TPM3

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16738805

Sources:
NCI
MIDAZOLAM BRD4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM GABRR3

Interaction Score: 0.27

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRR2

Interaction Score: 0.27

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRR1

Interaction Score: 0.25

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM PTH

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15657568

Sources:
NCI
MIDAZOLAM CREBBP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM TGM2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17093965

Sources:
NCI
MIDAZOLAM GABRQ

Interaction Score: 0.12

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM UGT1A4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIDAZOLAM GABRP

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRE

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRA1

Interaction Score: 0.11

Interaction Types & Directionality:

ligand

positive modulator (activating)

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456 29950725 23038269

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRD

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRG1

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRB3

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRB1

Interaction Score: 0.11

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM CYP2B6

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11470993 17638512

Sources:
PharmGKB
MIDAZOLAM GABRA4

Interaction Score: 0.1

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRA6

Interaction Score: 0.1

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRB2

Interaction Score: 0.1

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRG3

Interaction Score: 0.09

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRA5

Interaction Score: 0.09

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRA3

Interaction Score: 0.09

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRA2

Interaction Score: 0.09

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM CYP3A5

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28986606 25979262 24214410 23327575

Sources:
PharmGKB
MIDAZOLAM GABRG2

Interaction Score: 0.08

Interaction Types & Directionality:

potentiator

Interaction Info:

PMIDs:
11752090 18384456

Sources:
TEND
MIDAZOLAM CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9620522

Sources:
NCI
MIDAZOLAM TSPO

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MIDAZOLAM TNF

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16406030

Sources:
NCI
MIDAZOLAM CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528 26114223 25287072 23327575 19255940 25588320

Sources:
PharmGKB
MIDAZOLAM ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIDAZOLAM VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: MIDAZOLAM
- Version: 01-August-2011
Alternate Names:

MIDAZOLAM Primary Drug Name

Drug Info:

Year of Approval 1985

Drug Class adjuvants, anesthesia

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: MIDAZOLAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Adjuvants, Anesthesia

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
DTC: MIDAZOLAM
- Version: 02-September-2020
Alternate Names:

CHEMBL655 ChEMBL Drug ID

Drug Info:

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

NCI: MIDAZOLAM

Version: 14-September-2017

Alternate Names:

C654 NCI drug code

Drug Info:

Publications:

Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology

Sippel et al., 2004, Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trial., Surgery

Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol

PharmGKB: midazolam

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Elens L et al., 2013, Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin., Pharmacogenet Genomics

Oneda B et al., 2009, The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test., Pharmacogenet Genomics

Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

TTD: Midazolam
- Version: 2020.06.01
Alternate Names:

D0U6LM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL655
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

MIDAZOLAM Drug Record

MIDAZOLAM chembl:CHEMBL655 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23324807 19801957

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16738805

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15657568

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17093965

Sources: NCI

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: ligand positive modulator (activating) potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456 29950725 23038269

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18384456 11752090

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23324807 19801957

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16738805

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
15657568

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17093965

Sources:
NCI

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

ligand

positive modulator (activating)

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456 29950725 23038269

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
11470993 17638512

Sources:
PharmGKB

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456