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MIDAZOLAM Drug Record

  • Summary
  • Interactions
  • Claims
  • MIDAZOLAM chembl:CHEMBL655 Approved

    Alternate Names:

    USL261
    NAYZILAM
    MIDAZOLAM
    MIDAZOLAM CIV
    USL-261
    DORMICUM®
    VERSED®
    BUCCOLAM
    DORMICUM
    MIDAZOLAMUM
    rxcui:6960
    chembl:CHEMBL655
    drugbank:00683
    pubchem.compound:4192
    chemidplus:59467-70-8

    Drug Info:

    Drug Class hypnotics and sedatives
    Drug Class adjuvants, anesthesia
    Year of Approval 1985
    FDA Approval 1985
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Indications Adjuvants, Anesthesia
    (3 More Sources)

    Publications:

    Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
    Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol
    Elens L et al., 2013, Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin., Pharmacogenet Genomics
    Oneda B et al., 2009, The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test., Pharmacogenet Genomics
    Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
    Galley et al., 1998, The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes., Anesth. Analg.
    Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
    Zhou X et al., 2018, Effect of breviscapine on CYP3A metabolic activity in healthy volunteers., Eur J Clin Pharmacol
    Vyhlidal CA et al., 2015, Variability in Expression of CYP3A5 in Human Fetal Liver., Drug Metab Dispos
    Seng KY et al., 2014, CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients., J Clin Pharmacol
    Elens L et al., 2013, CYP3A4 intron 6 C&gt;T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin., Pharmacogenomics
    Lu et al., 2006, General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain., Apoptosis
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    de Jonge H et al., 2015, Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit., Br J Clin Pharmacol
    de Jonge H et al., 2015, The CYP3A4*22 C&gt;T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients., Pharmacogenomics J
    Maekawa K et al., 2009, Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine., Xenobiotica
    Hohmann N et al., 2015, Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans., Br J Clin Pharmacol
    Sippel et al., 2004, Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trial., Surgery
  • MIDAZOLAM   BRDT

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • MIDAZOLAM   POR

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23324807 19801957


    Sources:
    PharmGKB

  • MIDAZOLAM   BRD3

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • MIDAZOLAM   BRD2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • MIDAZOLAM   TPM3

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16738805


    Sources:
    NCI

  • MIDAZOLAM   BRD4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • MIDAZOLAM   GABRR3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRR2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRR1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   PTH

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15657568


    Sources:
    NCI

  • MIDAZOLAM   CREBBP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • MIDAZOLAM   TGM2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17093965


    Sources:
    NCI

  • MIDAZOLAM   GABRQ

    Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   UGT1A4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIDAZOLAM   GABRP

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456 11752090


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRG1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRB3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   CYP2B6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11470993 17638512


    Sources:
    PharmGKB

  • MIDAZOLAM   GABRA4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRA6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456 11752090


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRG3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRA5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRA3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   GABRA2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • MIDAZOLAM   CYP3A5

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28986606 25979262 24214410 23327575


    Sources:
    PharmGKB

  • MIDAZOLAM   GABRG2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11752090 18384456


    Sources:
    TEND

  • MIDAZOLAM   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9620522


    Sources:
    NCI

  • MIDAZOLAM   TSPO

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MIDAZOLAM   TNF

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16406030


    Sources:
    NCI

  • MIDAZOLAM   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 26114223 25287072 23327575 19255940 25588320


    Sources:
    PharmGKB

  • MIDAZOLAM   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIDAZOLAM   VDR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TEND: MIDAZOLAM

    • Version: 01-August-2011

    Alternate Names:
    MIDAZOLAM Primary Drug Name

    Drug Info:
    Year of Approval 1985
    Drug Class adjuvants, anesthesia
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: MIDAZOLAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Adjuvants, Anesthesia
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule

    Publications:

  • DTC: MIDAZOLAM

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL655 ChEMBL Drug ID

    Drug Info:

    Publications:
    Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

  • NCI: MIDAZOLAM

    • Version: 14-September-2017

    Alternate Names:
    C654 NCI drug code

    Drug Info:

    Publications:
    Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology
    Sippel et al., 2004, Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trial., Surgery
    Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol

  • PharmGKB: midazolam

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Elens L et al., 2013, Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin., Pharmacogenet Genomics
    Oneda B et al., 2009, The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test., Pharmacogenet Genomics
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

  • TTD: Midazolam

    • Version: 2020.06.01

    Alternate Names:
    D0U6LM TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL655

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21