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MIDODRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MIDODRINE chembl:CHEMBL1201212 Approved

    Alternate Names:

    ST 1085
    ST-1085
    MIDODRINE
    2-AMINO-N-(2,5-DIMETHOXY-BETA-HYDROXYPHENETHYL)ACETAMIDE
    A-4020 LINZ
    MIDODRIN
    PROAMATINEĀ®
    MIDODRINA
    (+-)-2-AMINO-N-(BETA-HYDROXY-2,5-DIMETHOXYPHENETHYL)ACETAMIDE
    1-(2',5'-DIMETHOXYPHENYL)-2-GLYCINAMIDOETHANOL
    DL-N1-(BETA-HYDROXY-2,5-DIMETHOXYPHENETHYL)GLYCINAMID
    MIDODRINUM
    chemidplus:42794-76-3
    drugbank:00211
    rxcui:6963
    chembl:CHEMBL1201212
    pubchem.compound:4195

    Drug Info:

    FDA Approval 1996
    Drug Class small molecule
    Drug Indications Vasoconstrictor Agents
    Drug Indications Antihypotensive Agents
    Drug Class antihypotensive agents
    Year of Approval 1996
    Drug Class vasoconstrictor agents
    (1 More Sources)

    Publications:

    Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
    Taniguchi et al., 1996, NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs., Eur. J. Pharmacol.
    Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
  • MIDODRINE   ADRA1A

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9007522 12163120 15163201


    Sources:
    TdgClinicalTrial TEND

  • MIDODRINE   ADRA1B

    Interaction Score: 0.44

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15163201


    Sources:
    TdgClinicalTrial TEND

  • MIDODRINE   CYP2C9

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MIDODRINE   CYP2C19

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MIDODRINE   CYP1A2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MIDODRINE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MIDODRINE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: MIDODRINE

    • Version: 01-August-2011

    Alternate Names:
    MIDODRINE Primary Drug Name

    Drug Info:
    Drug Class vasoconstrictor agents
    Year of Approval 1996
    Drug Class antihypotensive agents

    Publications:

  • TdgClinicalTrial: MIDODRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypotensive Agents
    Drug Indications Vasoconstrictor Agents
    Drug Class small molecule

    Publications:

  • DTC: MIDODRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1201212 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Midodrine

    • Version: 2020.06.01

    Alternate Names:
    D02XJY TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201212

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21