DGIdb - MIDODRINE Drug Record

MIDODRINE chembl:CHEMBL1201212 Approved

Alternate Names:

ST 1085
ST-1085
MIDODRINE
2-AMINO-N-(2,5-DIMETHOXY-BETA-HYDROXYPHENETHYL)ACETAMIDE
A-4020 LINZ
MIDODRIN
PROAMATINE®
MIDODRINA
(+-)-2-AMINO-N-(BETA-HYDROXY-2,5-DIMETHOXYPHENETHYL)ACETAMIDE
1-(2',5'-DIMETHOXYPHENYL)-2-GLYCINAMIDOETHANOL
DL-N1-(BETA-HYDROXY-2,5-DIMETHOXYPHENETHYL)GLYCINAMID
MIDODRINUM
chemidplus:42794-76-3
drugbank:00211
rxcui:6963
chembl:CHEMBL1201212
pubchem.compound:4195

Drug Info:

FDA Approval	1996
Drug Class	small molecule
Drug Indications	Vasoconstrictor Agents
Drug Indications	Antihypotensive Agents
Drug Class	antihypotensive agents
Year of Approval	1996
Drug Class	vasoconstrictor agents

(1 More Sources)

Publications:

Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
Taniguchi et al., 1996, NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs., Eur. J. Pharmacol.
Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

MIDODRINE ADRA1A

Interaction Score: 0.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9007522 12163120 15163201

Sources:
TdgClinicalTrial TEND
MIDODRINE ADRA1B

Interaction Score: 0.44

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15163201

Sources:
TdgClinicalTrial TEND
MIDODRINE CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MIDODRINE CYP2C19

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MIDODRINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MIDODRINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MIDODRINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: MIDODRINE
- Version: 01-August-2011
Alternate Names:

MIDODRINE Primary Drug Name

Drug Info:

Drug Class vasoconstrictor agents

Year of Approval 1996

Drug Class antihypotensive agents

Publications:
TdgClinicalTrial: MIDODRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Publications:
DTC: MIDODRINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1201212 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Midodrine
- Version: 2020.06.01
Alternate Names:

D02XJY TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201212
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

MIDODRINE Drug Record

MIDODRINE chembl:CHEMBL1201212 Approved

Alternate Names:

Drug Info:

Publications:

MIDODRINE ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9007522 12163120 15163201

Sources: TdgClinicalTrial TEND

MIDODRINE ADRA1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15163201

Sources: TdgClinicalTrial TEND

MIDODRINE CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MIDODRINE CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MIDODRINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MIDODRINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MIDODRINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: MIDODRINE

Alternate Names: MIDODRINE Primary Drug Name

Drug Info: Drug Class vasoconstrictor agents Year of Approval 1996 Drug Class antihypotensive agents

Publications:

TdgClinicalTrial: MIDODRINE

Alternate Names:

Drug Info: Drug Indications Antihypotensive Agents Drug Indications Vasoconstrictor Agents Drug Class small molecule

Publications:

DTC: MIDODRINE

Alternate Names: CHEMBL1201212 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Midodrine

Alternate Names: D02XJY TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201212

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9007522 12163120 15163201

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15163201

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

MIDODRINE Primary Drug Name

Drug Info:

Drug Class vasoconstrictor agents

Year of Approval 1996

Drug Class antihypotensive agents

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Alternate Names:

CHEMBL1201212 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D02XJY TTD Drug ID