DGIdb - MINOXIDIL Drug Record

MINOXIDIL chembl:CHEMBL802 Approved

Alternate Names:

REGAINE FOR WOMEN
ROGAINE
MEN'S ROGAINE
MINOXIDIL
U-10858
WOMEN'S ROGAINE
REGAINE FOR MEN
MINODYL
MINOXIDIL EXTRA STRENGTH
LONITEN
THEROXIDIL
ROGAINE EXTRA STRENGTH
LONOLOX
MINOXIMEN
ALOSTIL
2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE
ROGAINE®
MINOSSIDILE
MINOXIDILUM
TRICOXIDIL
REGAINE
6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE
NORMOXIDIL
APO-GAIN
chemidplus:38304-91-5
drugbank:00350
chembl:CHEMBL802
pubchem.compound:4201
rxcui:6984

Drug Info:

FDA Approval	1979
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Drug Class	vasodilator agents
Year of Approval	1979
Drug Class	antihypertensive agents

(3 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol
Bray et al., 1992, A specific binding site for K+ channel openers in rat aorta., J. Biol. Chem.
Evans et al., 2005, Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function., J. Exp. Biol.
Löffler-Walz et al., 1998, Binding of K(ATP) channel modulators in rat cardiac membranes., Br. J. Pharmacol.
Kirsten et al., 1998, Clinical pharmacokinetics of vasodilators. Part I., Clin Pharmacokinet
Black et al., 2008, Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models., Brain Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

MINOXIDIL KCNJ1

Interaction Score: 4.28

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1601843 16169954 9579735 9646008 18602898 17016423 17139284

Sources:
TdgClinicalTrial TEND
MINOXIDIL SULT1A1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2390100

Sources:
PharmGKB
MINOXIDIL ABCC9

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MINOXIDIL CALCA

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MINOXIDIL KCNJ11

Interaction Score: 0.22

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MINOXIDIL CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MINOXIDIL CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MINOXIDIL CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MINOXIDIL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MINOXIDIL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: MINOXIDIL
- Version: 01-August-2011
Alternate Names:

MINOXIDIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1979

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: MINOXIDIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
DTC: MINOXIDIL
- Version: 02-September-2020
Alternate Names:

CHEMBL802 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: minoxidil
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol
TTD: Minoxidil
- Version: 2020.06.01
Alternate Names:

D0Y2CJ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL802
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL802
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sulfonylurea receptor 2, Kir6.2 opener
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

MINOXIDIL Drug Record

MINOXIDIL chembl:CHEMBL802 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1601843 16169954 9579735 9646008 18602898 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2390100

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: MINOXIDIL

Alternate Names: MINOXIDIL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1979 Drug Class vasodilator agents

Publications:

TdgClinicalTrial: MINOXIDIL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

DTC: MINOXIDIL

Alternate Names: CHEMBL802 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: minoxidil

Alternate Names:

Drug Info:

Publications: Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol

TTD: Minoxidil

Alternate Names: D0Y2CJ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL802

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL802

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1601843 16169954 9579735 9646008 18602898 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
2390100

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

MINOXIDIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1979

Drug Class vasodilator agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

CHEMBL802 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol

Alternate Names:

D0Y2CJ TTD Drug ID