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MINOXIDIL Drug Record

  • Summary
  • Interactions
  • Claims
  • MINOXIDIL chembl:CHEMBL802 Approved

    Alternate Names:

    REGAINE FOR WOMEN
    ROGAINE
    MEN'S ROGAINE
    MINOXIDIL
    U-10858
    WOMEN'S ROGAINE
    REGAINE FOR MEN
    MINODYL
    MINOXIDIL EXTRA STRENGTH
    LONITEN
    THEROXIDIL
    ROGAINE EXTRA STRENGTH
    LONOLOX
    MINOXIMEN
    ALOSTIL
    2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE
    ROGAINE®
    MINOSSIDILE
    MINOXIDILUM
    TRICOXIDIL
    REGAINE
    6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE
    NORMOXIDIL
    APO-GAIN
    chemidplus:38304-91-5
    drugbank:00350
    chembl:CHEMBL802
    pubchem.compound:4201
    rxcui:6984

    Drug Info:

    FDA Approval 1979
    Drug Class small molecule
    Drug Indications Vasodilator Agents
    Drug Indications Antihypertensive Agents
    Drug Class vasodilator agents
    Year of Approval 1979
    Drug Class antihypertensive agents
    (3 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol
    Bray et al., 1992, A specific binding site for K+ channel openers in rat aorta., J. Biol. Chem.
    Evans et al., 2005, Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function., J. Exp. Biol.
    Löffler-Walz et al., 1998, Binding of K(ATP) channel modulators in rat cardiac membranes., Br. J. Pharmacol.
    Kirsten et al., 1998, Clinical pharmacokinetics of vasodilators. Part I., Clin Pharmacokinet
    Black et al., 2008, Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models., Brain Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
  • MINOXIDIL   KCNJ1

    Interaction Score: 4.28

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1601843 16169954 9579735 9646008 18602898 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • MINOXIDIL   SULT1A1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2390100


    Sources:
    PharmGKB

  • MINOXIDIL   ABCC9

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MINOXIDIL   CALCA

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MINOXIDIL   KCNJ11

    Interaction Score: 0.22

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MINOXIDIL   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MINOXIDIL   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MINOXIDIL   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MINOXIDIL   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MINOXIDIL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: MINOXIDIL

    • Version: 01-August-2011

    Alternate Names:
    MINOXIDIL Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1979
    Drug Class vasodilator agents

    Publications:

  • TdgClinicalTrial: MINOXIDIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Vasodilator Agents
    Drug Class small molecule

    Publications:

  • DTC: MINOXIDIL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL802 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: minoxidil

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Falany CN et al., 1990, Sulfation of minoxidil by human liver phenol sulfotransferase., Biochem Pharmacol

  • TTD: Minoxidil

    • Version: 2020.06.01

    Alternate Names:
    D0Y2CJ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL802

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL802

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21