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MIRTAZAPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MIRTAZAPINE chembl:CHEMBL654 Approved

    Alternate Names:

    MIRTAZAPINE
    REMERON
    REMERON SOLTAB
    ORG-3770
    ZISPIN
    1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO(2,1-A)PYRIDO(2,3-C)BENZAZEPINE
    6-AZAMIANSERIN
    MEPIRZAPINE
    MIRTAZAPINA
    MIRTAZAPIN
    REMERON®
    MIRTAZAPINUM
    2-METHYL-1,2,3,4,10,14B-HEXAHYDROPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE
    chemidplus:85650-52-8
    pubchem.compound:4205
    chemidplus:61337-67-5
    chembl:CHEMBL654
    rxcui:15996
    drugbank:00370

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antidepressant
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1996
    (4 More Sources)

    Publications:

    Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
    Anttila et al., 2001, A review of the pharmacological and clinical profile of mirtazapine., CNS Drug Rev
    Kast et al., 2007, Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects., Eur J Cancer Care (Engl)
    Westenberg, 1999, Pharmacology of antidepressants: selectivity or multiplicity?, J Clin Psychiatry
    Gorman, 1999, Mirtazapine: clinical overview., J Clin Psychiatry
    de Boer, 1995, The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission., Int Clin Psychopharmacol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rogoz et al., 2002, Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors., J. Physiol. Pharmacol.
    Besson et al., 2000, Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain., Eur Neuropsychopharmacol
    Rogóz et al., Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors., Pol J Pharmacol
    Schreiber et al., Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression?, J. Mol. Neurosci.
    García-Sevilla et al., 2004, Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment., Neuropsychopharmacology
    Haddjeri N et al., 1997, Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission., Naunyn Schmiedebergs Arch Pharmacol
    Lee HY et al., 2009, Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder., Brain Res
    Laakmann et al., 1999, Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects., Psychoneuroendocrinology
    Waldinger et al., 2000, Treatment of hot flushes with mirtazapine: four case reports., Maturitas
    Nutt, 1999, Care of depressed patients with anxiety symptoms., J Clin Psychiatry
    Celada P et al., 2004, The therapeutic role of 5-HT1A and 5-HT2A receptors in depression., J Psychiatry Neurosci
    Pawlyk AC et al., 2006, Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation., Brain Res
    Benelli et al., 2004, Influence of mirtazapine on the sexual behavior of male rats., Psychopharmacology (Berl.)
    Millan, Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies., Therapie
    Millan et al., 2000, Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram., Eur. J. Neurosci.
    Meert et al., 1997, Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats., Behav Pharmacol
    Dekeyne et al., 2001, Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats., Psychopharmacology (Berl.)
    de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
    Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
    Jaquenoud Sirot E et al., 2012, Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression., J Clin Psychopharmacol
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
    Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
    Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res
  • MIRTAZAPINE   TPH2

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18496129


    Sources:
    PharmGKB

  • MIRTAZAPINE   FKBP5

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20709156 15565110


    Sources:
    PharmGKB

  • MIRTAZAPINE   RABEP1

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • MIRTAZAPINE   SH2B1

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • MIRTAZAPINE   GAL

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIRTAZAPINE   HTR3A

    Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex
    Novel drug target Established target

    PMIDs:
    11607047 17587360 10446734 10446735 8930006 11752352


    Sources:
    TdgClinicalTrial TEND

  • MIRTAZAPINE   HTR2C

    Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2c (5-HT2c) receptor antagonist
    Direct Interaction yes

    PMIDs:
    14615872 16433010 10762339 9832994 11271412 11752352


    Sources:
    ChemblInteractions TEND TTD

  • MIRTAZAPINE   ADRA2A

    Interaction Score: 0.55

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

    PMIDs:
    11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MIRTAZAPINE   LEP

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12518269


    Sources:
    NCI

  • MIRTAZAPINE   HTR2A

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

    PMIDs:
    11607047 10446734 10446735 10451911 11063897 10446738 15309042 17067560


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MIRTAZAPINE   ADRA2C

    Interaction Score: 0.16

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    3419539 15771415


    Sources:
    ChemblInteractions

  • MIRTAZAPINE   SLC2A4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002093


    Sources:
    NCI

  • MIRTAZAPINE   CYP2B6

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926595


    Sources:
    PharmGKB

  • MIRTAZAPINE   ADRA2B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIRTAZAPINE   CYP3A5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • MIRTAZAPINE   HTR1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • MIRTAZAPINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MIRTAZAPINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MIRTAZAPINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MIRTAZAPINE

    • Version: 01-August-2011

    Alternate Names:
    MIRTAZAPINE Primary Drug Name

    Drug Info:
    Year of Approval 1996
    Drug Class antidepressive agents, tricyclic

    Publications:

  • TdgClinicalTrial: MIRTAZAPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: MIRTAZAPINE

    • Version: 14-September-2017

    Alternate Names:
    C29265 NCI drug code

    Drug Info:

    Publications:
    Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
    Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res

  • PharmGKB: mirtazapine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • DTC: MIRTAZAPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL654 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Mirtazapine

    • Version: 2020.06.01

    Alternate Names:
    D05ZIK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL654

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL654

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21