DGIdb - MODAFINIL Drug Record

MODAFINIL chembl:CHEMBL1373 Approved

Alternate Names:

PROVIGIL
CEP-1538
THN-102 COMPONENT MODAFINIL
DEP-1538
CRC-40476
MODAFINIL CIV
THN102 COMPONENT MODAFINIL
CRL-40476
MODAFINIL
MODERATEAFINIL
MODAFINILO
MODAFINILUM
PROVIGIL®
2-((DIPHENYLMETHYL)SULFINYL)ACETAMIDE
chembl:CHEMBL1373
rxcui:30125
pubchem.compound:4236
chemidplus:68693-11-8
drugbank:00745

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	central nervous system stimulant

(4 More Sources)

Publications:

Madras et al., 2006, Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro., J. Pharmacol. Exp. Ther.
Swanson, 2003, Role of executive function in ADHD., J Clin Psychiatry
Zhou et al., 2004, Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization., J. Med. Chem.
Wisor et al., 2001, Dopaminergic role in stimulant-induced wakefulness., J. Neurosci.
Dopheide et al., 2007, Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants., Eur. J. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Moresco M et al., 2016, Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1., Clin Neuropharmacol
Goudreau JL et al., 2002, Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease., Mov Disord
Woo JM et al., 2002, Catechol O-methyltransferase genetic polymorphism in panic disorder., Am J Psychiatry
Dauvilliers Y et al., 2002, Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil., Pharmacogenomics J
Alsobrook JP 2nd et al., 2002, Association between the COMT locus and obsessive-compulsive disorder in females but not males., Am J Med Genet
Ohara K et al., 1998, Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression., Neuroreport
Li T et al., 1997, Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder., Pharmacogenetics
Stein MB et al., 2005, COMT polymorphisms and anxiety-related personality traits., Neuropsychopharmacology
Enoch MA et al., 2003, Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism., Psychiatr Genet

MODAFINIL COMT

Interaction Score: 1.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12465073 12359690 11990384 11840516 9631418 9352569 15956988 12605099

Sources:
PharmGKB
MODAFINIL SLC6A3

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine transporter inhibitor

Trial Name modafinil,Provigil, Sparlon

PMIDs:
16885432 14658934 15537337 11222668 17477916

Sources:
TdgClinicalTrial ChemblInteractions TTD
MODAFINIL CYP3A5

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
MODAFINIL CYP2D6

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10820139 22931300

Sources:
DTC NCI PharmGKB FDA
MODAFINIL NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MODAFINIL ABCB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26757307

Sources:
PharmGKB
MODAFINIL CYP2C19

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
MODAFINIL CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MODAFINIL CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MODAFINIL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TdgClinicalTrial: MODAFINIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications central nervous system stimulant

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: MODAFINIL
- Version: 14-September-2017
Alternate Names:

C26661 NCI drug code

Drug Info:

Publications:

Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.
DTC: MODAFINIL
- Version: 02-September-2020
Alternate Names:

CHEMBL1373 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: modafinil

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Moresco M et al., 2016, Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1., Clin Neuropharmacol

Li T et al., 1997, Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder., Pharmacogenetics

TTD: Modafinil
- Version: 2020.06.01
Alternate Names:

D07HQC TTD Drug ID

Drug Info:

Publications:
FDA: Modafinil
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1373
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1373
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Dopamine transporter inhibitor
Trial Name	modafinil,Provigil, Sparlon

MODAFINIL Drug Record

MODAFINIL chembl:CHEMBL1373 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12465073 12359690 11990384 11840516 9631418 9352569 15956988 12605099

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Dopamine transporter inhibitor Trial Name modafinil,Provigil, Sparlon

PMIDs: 16885432 14658934 15537337 11222668 17477916

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10820139 22931300

Sources: DTC NCI PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26757307

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TdgClinicalTrial: MODAFINIL

Alternate Names:

Drug Info: Drug Indications central nervous system stimulant Drug Class Small Molecule FDA Approval approved

Publications:

NCI: MODAFINIL

Alternate Names: C26661 NCI drug code

Drug Info:

Publications: Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.

DTC: MODAFINIL

Alternate Names: CHEMBL1373 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: modafinil

Alternate Names:

Drug Info:

TTD: Modafinil

Alternate Names: D07HQC TTD Drug ID

Drug Info:

Publications:

FDA: Modafinil

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1373

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1373

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12465073 12359690 11990384 11840516 9631418 9352569 15956988 12605099

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine transporter inhibitor

Trial Name modafinil,Provigil, Sparlon

PMIDs:
16885432 14658934 15537337 11222668 17477916

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10820139 22931300

Sources:
DTC NCI PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26757307

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Drug Info:

Drug Indications central nervous system stimulant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C26661 NCI drug code

Publications:

Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.

Alternate Names:

CHEMBL1373 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D07HQC TTD Drug ID