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MODAFINIL Drug Record

  • Summary
  • Interactions
  • Claims
  • MODAFINIL chembl:CHEMBL1373 Approved

    Alternate Names:

    PROVIGIL
    CEP-1538
    THN-102 COMPONENT MODAFINIL
    DEP-1538
    CRC-40476
    MODAFINIL CIV
    THN102 COMPONENT MODAFINIL
    CRL-40476
    MODAFINIL
    MODERATEAFINIL
    MODAFINILO
    MODAFINILUM
    PROVIGIL®
    2-((DIPHENYLMETHYL)SULFINYL)ACETAMIDE
    chembl:CHEMBL1373
    rxcui:30125
    pubchem.compound:4236
    chemidplus:68693-11-8
    drugbank:00745

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications central nervous system stimulant
    (4 More Sources)

    Publications:

    Madras et al., 2006, Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro., J. Pharmacol. Exp. Ther.
    Swanson, 2003, Role of executive function in ADHD., J Clin Psychiatry
    Zhou et al., 2004, Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization., J. Med. Chem.
    Wisor et al., 2001, Dopaminergic role in stimulant-induced wakefulness., J. Neurosci.
    Dopheide et al., 2007, Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants., Eur. J. Pharmacol.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Moresco M et al., 2016, Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1., Clin Neuropharmacol
    Goudreau JL et al., 2002, Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease., Mov Disord
    Woo JM et al., 2002, Catechol O-methyltransferase genetic polymorphism in panic disorder., Am J Psychiatry
    Dauvilliers Y et al., 2002, Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil., Pharmacogenomics J
    Alsobrook JP 2nd et al., 2002, Association between the COMT locus and obsessive-compulsive disorder in females but not males., Am J Med Genet
    Ohara K et al., 1998, Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression., Neuroreport
    Li T et al., 1997, Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder., Pharmacogenetics
    Stein MB et al., 2005, COMT polymorphisms and anxiety-related personality traits., Neuropsychopharmacology
    Enoch MA et al., 2003, Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism., Psychiatr Genet
  • MODAFINIL   COMT

    Interaction Score: 1.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12465073 12359690 11990384 11840516 9631418 9352569 15956988 12605099


    Sources:
    PharmGKB

  • MODAFINIL   SLC6A3

    Interaction Score: 0.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine transporter inhibitor
    Trial Name modafinil,Provigil, Sparlon

    PMIDs:
    16885432 14658934 15537337 11222668 17477916


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • MODAFINIL   CYP3A5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • MODAFINIL   CYP2D6

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10820139 22931300


    Sources:
    DTC NCI PharmGKB FDA

  • MODAFINIL   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MODAFINIL   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26757307


    Sources:
    PharmGKB

  • MODAFINIL   CYP2C19

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC PharmGKB

  • MODAFINIL   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MODAFINIL   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MODAFINIL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TdgClinicalTrial: MODAFINIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications central nervous system stimulant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: MODAFINIL

    • Version: 14-September-2017

    Alternate Names:
    C26661 NCI drug code

    Drug Info:

    Publications:
    Robertson et al., 2000, In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil., Drug Metab. Dispos.

  • DTC: MODAFINIL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1373 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: modafinil

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Moresco M et al., 2016, Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1., Clin Neuropharmacol
    Li T et al., 1997, Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder., Pharmacogenetics

  • TTD: Modafinil

    • Version: 2020.06.01

    Alternate Names:
    D07HQC TTD Drug ID

    Drug Info:

    Publications:

  • FDA: Modafinil

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1373

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1373

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21