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MONTELUKAST Drug Record

  • Summary
  • Interactions
  • Claims
  • MONTELUKAST chembl:CHEMBL787 Approved

    Alternate Names:

    MK-476
    SINGULAIR
    MONTELUKAST
    SINGULAIR®
    MONTELUKASTUM
    (R-(E))-1-(((1-(3-(2-(7-CHLORO-2-QUINOLINYL)ETHENYL)PHENYL)-3-(2-(1-HYDROXY-1-METHYLETHYL)PHENYL)PROPYL)THIO)METHYL)CYCLOPROPANEACETIC ACID
    1-[[[(1 R)-1-[3-[(1E)-2-(7-CHLORO-2-QUINOLINYL)ETHENYL] PHENYL]-3-[2-(1-HYDROXY-1-METHYLETHYL)PHENYL]PROPYL]SULFANYL]METHYL]CYCLOPROPANEACETIC ACID
    MONTÉLUKAST
    chemidplus:158966-92-8
    chembl:CHEMBL787
    pubchem.compound:5281040
    drugbank:00471
    rxcui:88249

    Drug Info:

    Year of Approval 1998
    Drug Class anti-asthmatic agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiasthmatic agent
    (2 More Sources)

    Publications:

    Nayak, 2004, A review of montelukast in the treatment of asthma and allergic rhinitis., Expert Opin Pharmacother
    Alfieri et al., 2007, Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways., Auton Autacoid Pharmacol
    Langlois et al., 2006, Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism., J. Allergy Clin. Immunol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hamacher et al., 2007, Montelukast exerts no acute direct effect on NO synthases., Pulm Pharmacol Ther
    Zhang et al., 2004, Montelukast modulates lung CysLT(1) receptor expression and eosinophilic inflammation in asthmatic mice., Acta Pharmacol. Sin.
    Ramires et al., 2004, Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast., Biochem. Biophys. Res. Commun.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Perin P et al., 2014, Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma., Immunogenetics
    Hirvensalo P et al., 2018, Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics., Clin Pharmacol Ther
    Kim KA et al., 2013, Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans., J Clin Pharmacol
    Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics
    Dahlin A et al., 2015, Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma., PLoS One
  • MONTELUKAST   GALNT17

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26083242


    Sources:
    PharmGKB

  • MONTELUKAST   CA10

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24407380


    Sources:
    PharmGKB

  • MONTELUKAST   MLLT3

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26083242


    Sources:
    PharmGKB

  • MONTELUKAST   CYSLTR1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name loratadine + montelukast sodium,Claritin + Singulair
    Novel drug target Established target
    Trial Name montelukast sodium,Singulair

    PMIDs:
    15013935 17199874 16815146 11752352 16815057 15456537


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • MONTELUKAST   LTC4S

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MONTELUKAST   ABCC9

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28940478


    Sources:
    PharmGKB

  • MONTELUKAST   SLCO2B1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23970434 19151602


    Sources:
    PharmGKB

  • MONTELUKAST   UGT1A3

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28940478


    Sources:
    PharmGKB

  • MONTELUKAST   LTA4H

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MONTELUKAST   CYP2C8

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28940478


    Sources:
    PharmGKB

  • MONTELUKAST   ALOX5

    Interaction Score: 0.27

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    15474500


    Sources:
    PharmGKB

  • MONTELUKAST   ABCC1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MONTELUKAST   CYP3A5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • MONTELUKAST   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MONTELUKAST   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MONTELUKAST   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MONTELUKAST   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MONTELUKAST   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: MONTELUKAST

    • Version: 01-August-2011

    Alternate Names:
    MONTELUKAST Primary Drug Name

    Drug Info:
    Drug Class anti-asthmatic agents
    Year of Approval 1998

    Publications:

  • TdgClinicalTrial: MONTELUKAST

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiasthmatic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: MONTELUKAST

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL787 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: montelukast

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Hirvensalo P et al., 2018, Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics., Clin Pharmacol Ther
    Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics

  • TTD: Montelukast

    • Version: 2020.06.01

    Alternate Names:
    D00QET TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL787

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21