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MORPHINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MORPHINE chembl:CHEMBL70 Approved

    Alternate Names:

    IDS-NM-009
    INFUMORPH
    AVINZA
    N02AA01
    KADIAN
    MORPHINE
    DEPODUR
    ANHYDROUS MORPHINE
    (5Α,6Α)-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOL
    (5Α,6Α)-17-METHYL-7,8-DIDEHYDRO-4,5-EPOXYMORPHINAN-3,6-DIOL
    (5R,6S,9R,13S,14R)-4,5-EPOXY-N-METHYL-7-MORPHINEN-3,6-DIOL
    MORPHINE SULFATE
    ORAMORPH®
    (5ALPHA,6ALPHA)-17-METHYL-7,8-DIDEHYDRO-4,5-EPOXYMORPHINAN-3,6-DIOL
    (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
    MORPHINUM
    MORPHIUM
    MORPHIN
    (-)-MORPHINE
    (5ALPHA,6ALPHA)-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOL
    MORFINA
    MORPHIA
    (−)-MORPHINE
    MS CONTIN®
    chembl:CHEMBL70
    pubchem.compound:5288826
    rxcui:7052
    chemidplus:57-27-2
    drugbank:00295

    Drug Info:

    Year of Approval approved before 1982
    Drug Class analgesics, opioid
    Drug Class Small molecule
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    (3 More Sources)

    Publications:

    El-Hage et al., 2006, CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates., J. Neuroimmunol.
    Galeotti et al., 2006, Signaling pathway of morphine induced acute thermal hyperalgesia in mice., Pain
    Dortch-Carnes et al., 2006, Morphine-induced reduction of intraocular pressure and pupil diameter: role of nitric oxide., Pharmacology
    Yamada et al., 2006, Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors., Brain Res.
    Kieffer et al., 2002, Exploring the opioid system by gene knockout., Prog. Neurobiol.
    Asensio et al., 2006, Stimulation of mitogen-activated protein kinase kinases (MEK1/2) by mu-, delta- and kappa-opioid receptor agonists in the rat brain: regulation by chronic morphine and opioid withdrawal., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Koch et al., 2006, Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors., J. Neurochem.
    Robinson et al., 2002, Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult rats., Synapse
    Teodorov et al., 2006, Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat., Neuroscience
    Leventhal et al., 1998, Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats., J. Pharmacol. Exp. Ther.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Kozak et al., 1994, Murine chromosomal location of the mu and kappa opioid receptor genes., Genomics
    Chatti I et al., 2017, Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment., Iran J Public Health
    Zhu XL et al., 2020, Correlations of analgesic dosage of morphine with SLC6A4 gene polymorphisms in patients with lung cancer., Eur Rev Med Pharmacol Sci
    Aubrun F et al., 2018, Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study., Eur J Anaesthesiol
    Sadhasivam S et al., 2015, Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics., Pharmacogenomics J
    Venkatasubramanian R et al., 2014, ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children., Pharmacogenomics
    Bastami S et al., 2014, Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption., Basic Clin Pharmacol Toxicol
    Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
    Campa D et al., 2008, Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief., Clin Pharmacol Ther
    Coulbault L et al., 2006, Environmental and genetic factors associated with morphine response in the postoperative period., Clin Pharmacol Ther
    Cunningham CW et al., 2008, Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs., J Med Chem
    Sindrup SH et al., 1993, Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?, Pain
    Candiotti KA et al., 2009, The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption., Pain Med
    Foster A et al., 2007, Complicated pain management in a CYP450 2D6 poor metabolizer., Pain Pract
    Vaught et al., 1978, Characterization of leucine and methionine enkephalin and their interaction with morphine on the guinea pig ileal longitudinal muscle., Res. Commun. Chem. Pathol. Pharmacol.
    Ning M et al., 2019, Roles of UGT2B7 C802T gene polymorphism on the efficacy of morphine treatment on cancer pain among the Chinese han population., Niger J Clin Pract
    Nielsen LM et al., 2017, Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics., Eur J Pharm Sci
    Matic M et al., 2014, Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort., Pharmacogenomics
    Darbari DS et al., 2008, UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease., Am J Hematol
    Holthe M et al., 2002, Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy., Eur J Clin Pharmacol
    Liang et al., 2003, Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine., Neuroscience
    Li et al., 2000, Chronic morphine exposure and the expression of heme oxygenase type 2., Brain Res. Mol. Brain Res.
    Liu et al., 2005, [The effect of ribozyme specially cleaving per1 mRNA on c-fos mRNA and its expression in hippocampus of morphine addicted mice]., Space Med Med Eng (Beijing)
    Sharif et al., 2002, Attenuation of morphine tolerance after antisense oligonucleotide knock-down of spinal mGluR1., Br. J. Pharmacol.
    Xu et al., 1996, L-740,093, a new antagonist of the CCK-B receptor, potentiates the antinociceptive effect of morphine: electrophysiological and behavioural studies., Neuropeptides
    Ipp et al., 1980, Morphine-induced hyperglycemia: role of insulin and glucagon., Endocrinology
    Zhu et al., 2003, Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614., Brain Res. Mol. Brain Res.
    Singhal et al., 2002, Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis., J. Immunol.
    Nikolaev VO et al., 2007, Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors., J Biol Chem
    Vilardaga JP et al., 2008, Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling., Nat Chem Biol
    Tidgewell K et al., 2008, Herkinorin analogues with differential beta-arrestin-2 interactions., J Med Chem
    Choi et al., 2006, The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor., Biochem. Biophys. Res. Commun.
    Castro et al., 2006, A quantitative approach to measure joint pain in experimental osteoarthritis--evidence of a role for nitric oxide., Osteoarthr. Cartil.
    Johnson et al., 2006, Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells., Mol. Pharmacol.
    Somogyi AA et al., 2016, Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain., Pain
    Rouge-Pont et al., 2002, Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors., J. Neurosci.
    Menzebach et al., 2004, [Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism]., Anasthesiol Intensivmed Notfallmed Schmerzther
    Groer et al., 2007, An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization., Mol. Pharmacol.
    Werme et al., 2000, NGFI-B and nor1 mRNAs are upregulated in brain reward pathways by drugs of abuse: different effects in Fischer and Lewis rats., Brain Res. Mol. Brain Res.
    Hahn D et al., 2020, Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients., J Clin Pharmacol
    Parmar et al., 1987, Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats., Arch Int Pharmacodyn Ther
    Galvan A et al., 2011, Multiple Loci modulate opioid therapy response for cancer pain., Clin Cancer Res
    Khrenov et al., 2000, [Quantitative analysis of synaptophysin (p38) in the brain of the second generation offspring from male rats with long-term morphine intoxication]., Biull Eksp Biol Med
    Tzvetkov MV et al., 2013, Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration., Biochem Pharmacol
    Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit
    Matic M et al., 2017, Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement., Pharmacogenomics
    Hronová K et al., 2016, Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome., Physiol Res
    De Gregori M et al., 2016, Human Genetic Variability Contributes to Postoperative Morphine Consumption., J Pain
    Candiotti KA et al., 2014, Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain., Anesth Analg
    Matic M et al., 2014, Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype., Pharmacogenomics
    Cargnin S et al., 2013, An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans., J Pain
    De Gregori M et al., 2013, Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain., Eur J Clin Pharmacol
    Landau R et al., 2013, The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia., Anesth Analg
    Klepstad P et al., 2011, Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients., Pain
    Horowitz R et al., 2000, Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study., Am J Med Genet
    Vandenbergh DJ et al., 1997, High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers., Am J Med Genet
    Rakvåg TT et al., 2005, The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients., Pain
    Zubieta JK et al., 2003, COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor., Science
  • MORPHINE   SYP

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10710628


    Sources:
    NCI

  • MORPHINE   PDYN

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    705020


    Sources:
    NCI

  • MORPHINE   PER1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15977398


    Sources:
    NCI

  • MORPHINE   HMOX2

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14580950 10686338


    Sources:
    NCI

  • MORPHINE   TAOK3

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MORPHINE   RHBDF2

    Interaction Score: 1.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21622719


    Sources:
    PharmGKB

  • MORPHINE   LPAR2

    Interaction Score: 1.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17090705


    Sources:
    NCI

  • MORPHINE   COMT

    Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130 11054766 9259381 15927391 12595695


    Sources:
    PharmGKB

  • MORPHINE   KCNJ6

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27027462


    Sources:
    PharmGKB

  • MORPHINE   SULT1A4

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MORPHINE   GRM1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12110611


    Sources:
    NCI

  • MORPHINE   UGT2B7

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31607718 28063968 25340733 24703092 17724700 16580900 12185559


    Sources:
    PharmGKB

  • MORPHINE   OPRD1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT
    Novel drug target Established target
    Trial Name intranasal morphine,Rylomine

    PMIDs:
    16650582 16534251 16530171 12015197 16678156 11752352 16539674


    Sources:
    TdgClinicalTrial TEND

  • MORPHINE   TBXA2R

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3435201


    Sources:
    NCI

  • MORPHINE   NR4A1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10719211


    Sources:
    NCI

  • MORPHINE   ITGAM

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15098168


    Sources:
    NCI

  • MORPHINE   CCR2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16831471


    Sources:
    NCI

  • MORPHINE   SLC22A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23835420


    Sources:
    PharmGKB

  • MORPHINE   CCKBR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8771563


    Sources:
    NCI

  • MORPHINE   OPRK1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name TPM-1/Morphine
    Trial Name Statex
    Trial Name MoxDuo

    PMIDs:
    16753266 9808678 17016423 17139284 7959748 29259946


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • MORPHINE   GCG

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6993188


    Sources:
    NCI

  • MORPHINE   F2R

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12373743


    Sources:
    NCI

  • MORPHINE   OPRM1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT
    Novel drug target Established target
    Trial Name intranasal morphine,Rylomine

    PMIDs:
    17616524 18193048 18380425 16580639 16530171 16580848 16682505 11752352


    Sources:
    DTC TdgClinicalTrial TEND

  • MORPHINE   ABCC3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32090339


    Sources:
    PharmGKB

  • MORPHINE   IL1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27649267


    Sources:
    PharmGKB

  • MORPHINE   GRIN1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12829326


    Sources:
    NCI

  • MORPHINE   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29474345 25311385 25155932 24703092 19514130 17898703 16580900 18311899


    Sources:
    DTC PharmGKB

  • MORPHINE   SLC6A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32432768


    Sources:
    PharmGKB

  • MORPHINE   MAPK14

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11937560


    Sources:
    NCI

  • MORPHINE   DRD2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11943831


    Sources:
    NCI

  • MORPHINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8351162 19523031 17986163


    Sources:
    PharmGKB

  • TEND: MORPHINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class analgesics, opioid
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: MORPHINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: MORPHINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL70 ChEMBL Drug ID

    Drug Info:

    Publications:
    Cunningham CW et al., 2008, Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs., J Med Chem
    Nikolaev VO et al., 2007, Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors., J Biol Chem
    Vilardaga JP et al., 2008, Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling., Nat Chem Biol

  • NCI: MORPHINE

    • Version: 14-September-2017

    Alternate Names:
    C669 NCI drug code

    Drug Info:

    Publications:
    El-Hage et al., 2006, CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates., J. Neuroimmunol.
    Liu et al., 2005, [The effect of ribozyme specially cleaving per1 mRNA on c-fos mRNA and its expression in hippocampus of morphine addicted mice]., Space Med Med Eng (Beijing)
    Xu et al., 1996, L-740,093, a new antagonist of the CCK-B receptor, potentiates the antinociceptive effect of morphine: electrophysiological and behavioural studies., Neuropeptides

  • PharmGKB: morphine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Darbari DS et al., 2008, UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease., Am J Hematol
    Matic M et al., 2014, Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort., Pharmacogenomics
    Bastami S et al., 2014, Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption., Basic Clin Pharmacol Toxicol

  • TTD: Morphine

    • Version: 2020.06.01

    Alternate Names:
    D0WE3O TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL70

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21