• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NABIXIMOLS Drug Record

  • Summary
  • Interactions
  • Claims
  • NABIXIMOLS chembl:CHEMBL3833333

    Alternate Names:

    NABIXIMOLS
    GW 1000-02
    GW-1000
    SAB 378
    SATIVEX
    GW 1000
    CANNABINOIDS
    SAB-378

    Drug Info:

    Drug Type small molecule
    Drug Groups investigational
    Drug Categories agents producing tachycardia
    Drug Categories analgesics
    Drug Categories bcrp/abcg2 inhibitors
    Drug Categories cannabinoid receptor agonists
    Drug Categories cannabinoids and similars
    Drug Categories central nervous system agents
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a5 inhibitors
    Drug Categories cytochrome p-450 cyp3a5 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a7 inhibitors
    Drug Categories cytochrome p-450 cyp3a7 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories peripheral nervous system agents
    Drug Categories pharmaceutical preparations
    Drug Categories sensory system agents
    Drug Categories terpenes
    (0 More Sources)

    Publications:

    Tyndale RF et al., 2007, The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians., Am J Med Genet B Neuropsychiatr Genet
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Schinka JA et al., 2002, A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances., Mol Psychiatry
    Türkan H et al., 2019, The association between the OPRM1 A118G polymorphism and addiction in a Turkish population., Arh Hig Rada Toksikol
    Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
    Bisogno T et al., 2001, Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide., Br J Pharmacol
    Iannotti FA et al., 2014, Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability., ACS Chem Neurosci
  • NABIXIMOLS   GPX1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   ACAT1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   NAAA

    Interaction Score: 0.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CRYZ

    Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   VDAC1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CAT

    Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   TRPV2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GPR18

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   AANAT

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GPR12

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    26218440


    Sources:
    DrugBank

  • NABIXIMOLS   CYP3A7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • NABIXIMOLS   TRPV4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • NABIXIMOLS   TRPV3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   FAAH

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inducer (activating)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17290447 26264914


    Sources:
    PharmGKB DrugBank

  • NABIXIMOLS   SOD1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   TRPM8

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GLRA3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   IDO1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP1A1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GPR55

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GSR

    Interaction Score: 0.11

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   TRPV1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11606325 25029033 26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CACNA1I

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CACNA1G

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP17A1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • NABIXIMOLS   HMGCR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   KAT2B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NABIXIMOLS   GLRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   TRPA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP1B1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CACNA1H

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CNR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26218440


    Sources:
    DrugBank

  • NABIXIMOLS   OPRM1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11840318 31246565 26264914


    Sources:
    PharmGKB DrugBank

  • NABIXIMOLS   CHRNA7

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CNR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • NABIXIMOLS   OPRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP3A5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   PTGS1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   PTGS2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   HTR1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    substrate

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • DrugBank: DB14011

    • Version: 5.1.7

    Alternate Names:
    NABIXIMOLS DrugBank Drug Name
    56575-23-6 CAS Number
    CHEMBL3833333 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories agents producing tachycardia

    Publications:
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
    Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev

  • PharmGKB: cannabinoids

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Tyndale RF et al., 2007, The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians., Am J Med Genet B Neuropsychiatr Genet
    Schinka JA et al., 2002, A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances., Mol Psychiatry
    Türkan H et al., 2019, The association between the OPRM1 A118G polymorphism and addiction in a Turkish population., Arh Hig Rada Toksikol

  • ChemblDrugs: chembl:CHEMBL3833333

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21