• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NABUMETONE Drug Record

  • Summary
  • Interactions
  • Claims
  • NABUMETONE chembl:CHEMBL1070 Approved

    Alternate Names:

    BRL-14777
    NABUMETONE
    RELIFEX
    RELAFEN
    NABUMETONUM
    RELAFEN®
    4-(6-METHOXY-2-NAPHTHALENYL)-2-BUTANONE
    NABUMÉTONE
    4-(6-METHOXY-2-NAPHTHYL)-2-BUTANONE
    NABUMETONA
    NABUMETON
    drugbank:00461
    rxcui:31448
    chemidplus:42924-53-8
    chembl:CHEMBL1070
    pubchem.compound:4409

    Drug Info:

    FDA Approval 1991
    Drug Class small molecule
    Drug Indications Anti-Inflammatory Agents, Non-Steroidal
    Year of Approval 1991
    Drug Class anti-inflammatory agents, non-steroidal
    (3 More Sources)

    Publications:

    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Takeuchi et al., 2006, Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease., Clin. Gastroenterol. Hepatol.
    Bensen et al., 1998, Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis., Can Fam Physician
    Giuliano et al., 2001, Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation., Eur. J. Pharmacol.
    Cipollone et al., 1995, Effects of nabumetone on prostanoid biosynthesis in humans., Clin. Pharmacol. Ther.
    Fackovcova et al., 2000, Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance., Bratisl Lek Listy
    Elliott et al., 1995, A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats., Gastroenterology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Roy et al., 2001, Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone., Int. J. Cancer
    van Kraaij et al., 2002, A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers., Br J Clin Pharmacol
    Hedner et al., 2004, Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis., Drugs
  • NABUMETONE   CYP2J2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • NABUMETONE   PTGS2

    Interaction Score: 1.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase-2 inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11153163 7615202 11752352 11304699 12047490 15456329


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • NABUMETONE   PTGS1

    Interaction Score: 0.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    16469680 9481468 11525777 7554708


    Sources:
    TdgClinicalTrial TEND

  • NABUMETONE   RAPGEF4

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NABUMETONE   SMN2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NABUMETONE   SMN1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NABUMETONE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: NABUMETONE

    • Version: 01-August-2011

    Alternate Names:
    NABUMETONE Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval 1991

    Publications:

  • TdgClinicalTrial: NABUMETONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Inflammatory Agents, Non-Steroidal
    Drug Class small molecule
    FDA Approval 1991

    Publications:

  • PharmGKB: nabumetone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

  • DTC: NABUMETONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1070 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Nabumetone

    • Version: 2020.06.01

    Alternate Names:
    D05CKR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1070

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1070

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21